Protein Alignment Nlg4 and Ces5a

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_001368779.1
• Gene: Ces5a / 67935
• MGIID: 1915185
• Length: 579
• Species: Mus musculus
• Alignment Length: 679
• Identity: 183/679 - (26%)
• Similarity: 279/679 - (41%)
• Gaps: 176/679 - (25%)

  Fly    26 AGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRA 90
            ||:.|.:.::..:||.  ||.:...:.|.:.|         |.||||:|:|.||....|||..:.
Mouse    28 AGSVTEEPHRYTKLGW--VQGKQATVLGRLEP---------VNVFLGIPFAAPPLGPLRFSKPQP 81

  Fly    91 PAPWDGIRISDKYSPVCPQRLPNI---QNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVF 152
            |.|||.:|.:..|..:|.|.|..:   ||              .||...|.| ..||||||||::
Mouse    82 PIPWDNLREATAYPNLCFQNLEWLFIYQN--------------LLKVSYPIL-GMSEDCLYLNIY 131

  Fly   153 SPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHA 217
            :|.:|. |...|||:|:|.|..||..|.:.:|||.||.|.:|:|||:.|||||.||.... |.||
Mouse   132 APCHAN-NGSSLPVMVWIPGGGFETGSASIFDGSALAVYEDVLVVTIQYRLGIFGFFTTQ-NQHA 194

  Fly   218 HARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILM 282
               ..|:...||:|||.|:::||:.|||:|:|||:.|:..||..|:.|:.|| :...||||||:.
Mouse   195 ---PGNWAFWDQLAALLWVRENIKYFGGNPDSVTIFGNSAGAISISSLILSP-LSADLFHRAIMQ 255

  Fly   283 SGSAYSSWALVEDPVLFAIK------------LAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLY 335
            ||.|          ::.::|            :|...:|.:.|.     :.::.|||:....:|.
Mouse   256 SGVA----------IIPSLKSSDNDLKHDLQVVANVCDCNVSDS-----KALLKCLREKSSLELM 305

  Fly   336 LADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGG 400
            ....:|    .||...|||...    |...::.|..:..:...:..|..:..
Mouse   306 SLSQKA----KSFTRVVDGSFF----SEEPLELLSQKTLKIVPSIIGVNNQE------------- 349

  Fly   401 GGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGFEGERRDKIIRTYV 465
                      .||.       :.:....::|.|  :.||......|.:.:          |.|
Mouse   350 ----------CGYI-------LPVRDTPEILLG--SNESTALTLIHTLLH----------IPT-- 383

  Fly   466 RNAYNYHLNEIFYTIVNEYTDWDRTSQH-PINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPV 529
                 .||    |.:..||..    .:| |.:.|||.:....|..||.|
Mouse   384 -----QHL----YIVTKEYFH----GKHSPTDIRDTLLDLFGDVFFVVP---------------- 419

  Fly   530 SSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTK--DGDYPQRMGTVHGEDLPYIFGAPLV 592
                         ...|:.......|..|||.|.::..  ....|..:...|.:::.::||.|.:
Mouse   420 -------------GLVTARYHRDSGGPVYFYEFQHRPHCFQNSRPAFVKADHTDEIRFVFGGPFL 471

  Fly   593 DGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLH 657
            .|.....:..|:.|..||..:|.:|.||||:|:||     .:.||           .|..||. :
Mouse   472 KGDVVMFEEATEEEKLLSRKMMKYWANFARSGDPN-----GADLP-----------PWPVYDE-N 519

  Fly   658 QKYLEIGMKPRIKNHFRAHQLSIWLRLIP 686
            ::|||:.:........:..::..|...:|
Mouse   520 EQYLELDVNISTGRRLKDQRVEFWTDTLP 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	176/655 (27%)
Ces5a	NP_001368779.1	COesterase	33..543	CDD:395084	178/667 (27%)