Protein Alignment Nlg4 and ces2b

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: XP_021326380.1
• Gene: ces2b / 561967
• ZFINID: ZDB-GENE-041014-96
• Length: 1611
• Species: Danio rerio
• Alignment Length: 694
• Identity: 189/694 - (27%)
• Similarity: 282/694 - (40%)
• Gaps: 175/694 - (25%)

  Fly    15 LPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPL---DSFRFLRSVEVFLGVPYA 76
            ||.::..|.           :|.     :|:|:.|.|.|..|.:   |:.     |..:||||:|
Zfish  1070 LPQIIKEWK-----------EGP-----VVETKLGSLRGAFLTVKGKDTI-----VNSYLGVPFA 1113

  Fly    77 TPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLEN 141
            .||....|.:..:|...|.|:|.:.|...:|.|.           .:|....||:|...:...|
Zfish  1114 KPPVGPLRLARPQAAEKWQGVRDATKQPRMCLQE-----------RQMTVTELEFLSMDVEVPE- 1166

  Fly   142 QSEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGIL 206
            .||||||||:::||..|..:|||||:|:|||......|.:.|||||||:|.:||||.:.||||:|
Zfish  1167 VSEDCLYLNIYTPVKPGQGDKKLPVMVWIHGGGLSLGSASMYDGSVLAAYQDVVVVLIQYRLGLL 1231

  Fly   207 GFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTM 271
            |||:.. :.||   ..|||.:||:|||.|:|:||..|||||.|||:.|...|...::.|:.|| :
Zfish  1232 GFLSTG-DEHA---PGNYGFLDQVAALQWVQENIHSFGGDPGSVTIFGESAGGISVSTLILSP-L 1291

  Fly   272 VRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYL 336
            ..|||||||..||:|:....::.||...|...||:.||.     :....:||||:.....|:...
Zfish  1292 ASGLFHRAIAESGTAFWDGLVMADPFQRAQTAAKQCNCD-----SSSSAKIVDCIMHWSEEEALE 1351

  Fly   337 ADIQAPNF-LTSFGPSVDGVVI-RPGHSNLDIDDLMARNS-RRSSADSGFQSSAGGGGGQGGGAG 398
            .   |..| :..|..:||...: :|      |::::.:.. .:....:|..:..
Zfish  1352 C---AKKFQMMHFSVAVDSYFLPKP------IEEIVEKQEFSKVPLINGINNDE----------- 1396

  Fly   399 GGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGFEGER-RDKIIR 462
                                             ||.:..|   .|...:..||.:.|: .:.:..
Zfish  1397 ---------------------------------FGFLLAE---YFLGPEWMNGLKREQIAEALTL 1425

  Fly   463 TYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPP 527
            ||......:    |...:..||..   .:..||..|:.....:.|..|..|.::    ||.:
Zfish  1426 TYPDPKDRW----IIDLVAKEYLG---DTHDPIEIREVYREMMGDVLFNIPALQ----LAKH--- 1476

  Fly   528 PVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDY-----QTKDGDYPQRMGTVHGEDLPYIF 587
                .|..|:|                  .|.|...:     |.|   .|..:|..|.:||.:|.
Zfish  1477 ----HSGTGAP------------------VYLYELQHPPSFLQKK---RPSFVGVDHADDLYFIQ 1516

  Fly   588 GAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPN----EHHRQDSSLPVSKERNRFRSI 648
            |.............:|:.|..|...||.:|.|||.||:||    .|
Zfish  1517 GTCFAKAHLRISAPFTEEENELCRTVMAYWGNFAHTGSPNGPGLTH------------------- 1562

  Fly   649 TWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAG 692
             |..|:. ..:||.||::.:...:.:........:.:|||.|.|
Zfish  1563 -WPEYEN-ENEYLAIGLQQKPGKNLKHKHYEFMTKTLPELIRQG 1604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	180/653 (28%)
ces2b	XP_021326380.1	COesterase	27..539	CDD:395084
		COesterase	553..1065	CDD:395084
		COesterase	1079..1592	CDD:395084	181/660 (27%)