Protein Alignment Nlg4 and Ces1e

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_113753.2
• Gene: Ces1e / 29225
• RGDID: 621508
• Length: 561
• Species: Rattus norvegicus
• Alignment Length: 694
• Identity: 185/694 - (26%)
• Similarity: 277/694 - (39%)
• Gaps: 186/694 - (26%)

  Fly    40 GH----RIVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRIS 100
            ||    .:|.|..|::.|..:.|:.  |.:.|.||||||:|.||....||:|.:...||..::.:
  Rat    18 GHPSSLPVVDTLQGKVLGKYVSLEG--FTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNT 80

  Fly   101 DKYSPVCPQR--LPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEKK 163
            ..|.|:|.|.  ...|.|:      :...|.|.:.  |.|    ||||||||:::|.:. ....:
  Rat    81 TSYPPMCSQDPVAGQIVND------LLTNREENIS--LQF----SEDCLYLNIYTPADL-TKRDR 132

  Fly   164 LPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMD 228
            |||:|:|||........:.|||..|:::..||||.:.|||||.||.:....   |:| .|:|.:|
  Rat   133 LPVMVWIHGGGLVLGGASTYDGLALSTHENVVVVVIQYRLGIWGFFSTGDE---HSR-GNWGHLD 193

  Fly   229 QMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALV 293
            |:|||||:|.||..|||||.|||:.|...|...::.|:.|| :.:.|||:||..||.|.::..:.
  Rat   194 QVAALHWVQDNIDNFGGDPGSVTIFGESAGGESVSVLVLSP-LAKNLFHKAISESGVALTAGLVK 257

  Fly   294 EDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTS----------F 348
            ::....|.|:|....|.     :.....:|.|||....|:|....::...|...          |
  Rat   258 KNTRPLAEKIAVVSGCK-----STTSAAMVHCLRQKTEEELLETTLKLNLFSLDLHGDSRQSYPF 317

  Fly   349 GPSV-DGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGG 412
            .|:| ||||             :.:......|:..|.:
  Rat   318 VPTVLDGVV-------------LPKMPEEILAEKDFNT--------------------------- 342

  Fly   413 YFGGSGAGTMNMGGHYDVLFGVVTGESIW------RFSAHDIQNGFEGERRDKIIRTYVRNAYNY 471
                           ...:.|:...|..|      .:...|:       :.|.:..|.:....::
  Rat   343 ---------------VPYIVGINKQEFGWILPTMMNYPPSDM-------KLDPMTATSLLKKSSF 385

  Fly   472 HLN---EIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSS 533
            .||   |.....|.:|.   |.:..|...:|..:..:.|..|..|.|
  Rat   386 LLNLPEEAIPVAVEKYL---RHTDDPDRNKDQLLELIGDVIFGVPSV------------------ 429

  Fly   534 TAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRM--GTV---HGEDLPYIFGAPLVD 593
                       ..|.|......|.|.|.|.|:.   .:..:|  .||   ||:::..:||||::.
  Rat   430 -----------IVSRGHRDAGARTYMYEFQYRP---SFSSKMKPSTVVGDHGDEIYSVFGAPILR 480

  Fly   594 GFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQ 658
            |      ..:|.|..||:.:|.||.||||.||||     ...||           .|..||   |
  Rat   481 G------GTSKEEINLSKMMMKFWANFARNGNPN-----GQGLP-----------HWPEYD---Q 520

  Fly   659 K--YLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARH 700
            |  ||:||...:.....:..:::.|..|:      .|:.:.|.|
  Rat   521 KEGYLQIGATTQQAQKLKEKEVAFWSELL------AMKPLHAGH 558

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	178/666 (27%)
Ces1e	NP_113753.2	COesterase	24..545	CDD:395084	178/667 (27%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561		1/1 (100%)