Protein Alignment Nlg4 and Cel

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_058693.2
• Gene: Cel / 24254
• RGDID: 2331
• Length: 612
• Species: Rattus norvegicus
• Alignment Length: 745
• Identity: 205/745 - (27%)
• Similarity: 293/745 - (39%)
• Gaps: 239/745 - (32%)

  Fly    25 CAGASTADIYKGARLGHRIVQTRYGRLHGL-----ILPLDSFRFLRSVEVFLGVPYATPPTKQNR 84
            |..|:.|     |:||  .|.|..|.:.|:     :|..|      ||::|.|:|:||..|.:|
  Rat    14 CLAAACA-----AKLG--AVYTEGGFVEGVNKKLSLLGGD------SVDIFKGIPFATAKTLEN- 64

  Fly    85 FSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYL 149
              |.|.|. |.|...:..:...|.|.... |::|..                      .||||||
  Rat    65 --PQRHPG-WQGTLKATDFKKRCLQATIT-QDDTYG----------------------QEDCLYL 103

  Fly   150 NVFSPVNAGANEKKLPVIVFIHGESFEWSSGNP--------YDGSVLASYGEVVVVTLNYRLGIL 206
            |::.|.........|||:|:|:|.:|...||..        |||..:|:.|.|:|||.|||:|.|
  Rat   104 NIWVPQGRKQVSHDLPVMVWIYGGAFLMGSGQGANFLKNYLYDGEEIATRGNVIVVTFNYRVGPL 168

  Fly   207 GFL---NAN-PNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMT 267
            |||   :|| |        .|:||.||..|:.|:::||..|||||:::|:.|...|||.::....
  Rat   169 GFLSTGDANLP--------GNFGLRDQHMAIAWVKRNIAAFGGDPDNITIFGESAGAASVSLQTL 225

  Fly   268 SPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLE 332
            || ..:||..|||..||.|.|.||:.|:|:.:|..:||:|.|...|.     .::..||:.....
  Rat   226 SP-YNKGLIRRAISQSGVALSPWAIQENPLFWAKTIAKKVGCPTEDT-----AKMAGCLKITDPR 284

  Fly   333 DLYLA--------DIQAPNFLTSFGPSVDGVVIRPGHSNL-----DIDDLMARNSRRSSADSGFQ 384
            .|.||        :....::| :|.|.|||..|.....||     |||.|
  Rat   285 ALTLAYRLPLKSQEYPIVHYL-AFIPVVDGDFIPDDPINLYDNAADIDYL--------------- 333

  Fly   385 SSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGV------------VTG 437
                                              ||..:|.||   ||..            ||.
  Rat   334 ----------------------------------AGINDMDGH---LFATVDVPAIDKAKQDVTE 361

  Fly   438 ESIWRF-SAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPI--NTRD 499
            |..:|. |.|.:..|.:|                   .:..:.|..|  .|   :|.|.  |.:.
  Rat   362 EDFYRLVSGHTVAKGLKG-------------------TQATFDIYTE--SW---AQDPSQENMKK 402

  Fly   500 TAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDY 564
            |.||..:|..|:.|...|   ||.:.              |:|          .|.:.|.|:|.:
  Rat   403 TVVAFETDILFLIPTEMA---LAQHR--------------AHA----------KSAKTYSYLFSH 440

  Fly   565 QTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEH 629
            .::...||:.||..|.:||.|:||.|...     |..|...:..:|:|::.:|||||::|:||
  Rat   441 PSRMPIYPKWMGADHADDLQYVFGKPFAT-----PLGYRAQDRTVSKAMIAYWTNFAKSGDPN-- 498

  Fly   630 HRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMK---PRIKNHFRAHQLSIW---LRLIPEL 688
             ..:|.:|..          |..|...:..||:|..|   ..:|.|.|...|..|   ..::|
  Rat   499 -MGNSPVPTH----------WYPYTTENGNYLDINKKITSTSMKEHLREKFLKFWAVTFEMLP-- 550

  Fly   689 HRAGMEDVIARHNLFRNHDDMDLYEGPVKP 718
                  .|:..|.  ...||.:  ..||.|
  Rat   551 ------TVVGDHT--PPEDDSE--AAPVPP 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	190/685 (28%)
Cel	NP_058693.2	COesterase	26..542	CDD:395084	190/684 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	553..612		6/22 (27%)
		4 X 11 AA tandem repeats, O-glycosylated region	556..599		6/19 (32%)