Protein Alignment Nlg4 and cest-8

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_001359583.1
• Gene: cest-8 / 182818
• WormBaseID: WBGene00007691
• Length: 605
• Species: Caenorhabditis elegans
• Alignment Length: 726
• Identity: 157/726 - (21%)
• Similarity: 251/726 - (34%)
• Gaps: 251/726 - (34%)

  Fly     8 LLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLD--SFRFLRSVEVF 70
            :|:.:|||.::|              |:...|  :|:.|.||:|.|:....|  :.:|     .|
 Worm     1 MLVSILLLCSLL--------------YEFQTL--KIINTSYGKLRGMAEWSDDANHKF-----TF 44

  Fly    71 LGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRL 135
            ..||:|.||....||:|.:....||||..:..||..|      :.|.|...:       .|:
 Worm    45 KSVPFAKPPIGNLRFAPPQKLDHWDGILDASVYSAAC------MSNSTLTTQ-------SYV--- 93

  Fly   136 LPFLENQSEDCLYLNVFSPVNAGANEK----KLPVIVFIHGESFEWSSGNPY-DGSVLASY--GE 193
                   :|||||:|:|:      :||    |..|||:.||.::...|...: |..:|..|  .:
 Worm    94 -------NEDCLYINIFT------SEKCLKSKCSVIVYFHGGAYNTESATMFSDRFILDRYVHED 145

  Fly   194 VVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTG 258
            |:.|....|||:.|.|...||.:.   ..|..:.|.:.||.::...|..|||||..||:.||.:|
 Worm   146 VIFVIPAVRLGVFGQLYFGPNAYL---TENLFMFDAILALDFVHNEISNFGGDPEKVTIMGHSSG 207

  Fly   259 AACINYL----MTSPTMVRGLFHRAILMSGSAY---------SSWALVEDPVLFAIKLAKEVNCT 310
            ...:..|    |..|.:  .||.:.|::|.:..         :|:.:||.  |......||...|
 Worm   208 GTLVEALGFSSMVDPEL--KLFQQMIMLSSTGMFGFDDLVIDNSFTIVEK--LGCFNGTKEERNT 268

  Fly   311 IPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDI-DDLMARNS 374
            :      :..:.:||:|                       .:||..|......::: |.|..:..
 Worm   269 V------NVAETLDCMR-----------------------HIDGYEILRVQQKMELMDQLSFKYL 304

  Fly   375 RRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHY-DVLFGVVTGE 438
            .|                                         ||..|.:.|:. |:........
 Worm   305 LR-----------------------------------------GAPFMLLNGNIADLKKNTSPRN 328

  Fly   439 SIWRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDTAVA 503
            :|:..:.|:.                      :.:.|.:..|...:.|:    ::|:     |||
 Worm   329 AIFGTTEHEF----------------------FDVTEKYLYITVTFLDY----ENPV-----AVA 362

  Fly   504 ALSDAQFVAPIVRAGDILAANSPPPVSSSSTA--GSPGANAAASTSAGSTQPSGRCYFYVFDYQT 566
            ...|.:           |..|....::..|.|  .|....|||..:||:.         ||.::|
 Worm   363 RNYDGR-----------LMKNMETMITGDSAAIFVSTATCAAAMANAGAD---------VFLFET 407

  Fly   567 KDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHR 631
            :. .|     :||..|:.|..|       :|...|.|.....|........|||.:.|.|
 Worm   408 RQ-SY-----SVHVSDMQYFIG-------NHCAHNRTIDIDILDSFYSKLLTNFTKHGKP----- 454

  Fly   632 QDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMK------PRIKNHFRAHQLSIWLRLIPEL-- 688
                           |..|:..||....|||:.:.      |.:...:.|..:|.|:..:.|.
 Worm   455 ---------------SPGWDPVDPGRMNYLELKVDSKARSGPVMLEGYHAKDVSFWVGEMTEFDQ 504

  Fly   689 ------HRAGM 693
                  |..|:
 Worm   505 NVSKMRHSEGL 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	146/669 (22%)
cest-8	NP_001359583.1	alpha/beta hydrolases	19..495	CDD:473884	146/670 (22%)