Protein Alignment Nlg4 and nlgn1

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: XP_017949302.2
• Gene: nlgn1 / 100329186
• XenbaseID: XB-GENE-6041753
• Length: 859
• Species: Xenopus tropicalis
• Alignment Length: 920
• Identity: 284/920 - (30%)
• Similarity: 402/920 - (43%)
• Gaps: 263/920 - (28%)

  Fly    43 IVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVC 107
            :|.|.||::.|....|:: ..|..|..|||||||.||..:.||.|...|..|..|:.|.:::|||
 Frog    54 VVLTTYGKVRGFKKELNN-EILGPVVQFLGVPYAAPPIGERRFQPPEPPTMWGDIKNSTQFAPVC 117

  Fly   108 PQ-----RLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPV------------ 155
            ||     |||.:.        :|......|..:..::::|||||||||::.|.
 Frog   118 PQNIVGGRLPEVM--------LPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDVKRISKECAR 174

  Fly   156 -----------------------NAGANEKKL-------PVIVFIHGESFEWSSGNPYDGSVLAS 190
                                   |.||.::.:       ||:|:|||.|:...:||.:|||||||
 Frog   175 KPGKKICRKEGPLTKKQTDDLGDNEGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNVFDGSVLAS 239

  Fly   191 YGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGH 255
            ||.|:|:|:|||||:||||:...    .|...||||:|.:.||.|..:||..|||||..:|:.|.
 Frog   240 YGNVIVITVNYRLGVLGFLSTGD----QASKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGS 300

  Fly   256 GTGAACINYLMTS--------PTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIP 312
            |.||:|:|.|..|        ....:|||.|||..||:|.||||:...|..:|..||.:|.|.:.
 Frog   301 GAGASCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARILATKVGCNMS 365

  Fly   313 DDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDD---LMARNS 374
            |.     .::|:||:..|..:|...|||...:..:|||.:||.||.        ||   ||.:
 Frog   366 DS-----GELVECLQKKPYRELVDQDIQPVRYHIAFGPVIDGDVIP--------DDPQVLMEQ-- 415

  Fly   375 RRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGES 439
                                                 |.|       :|    ||::.||..||.
 Frog   416 -------------------------------------GEF-------LN----YDIMLGVNQGEG 432

  Fly   440 IWRF--SAHDIQNGFEGERRDKIIRTYVRNAYNYH-----LNEIFYTIVNEYTDW-DRTSQHPIN 496
            : :|  |..|.::|......|..:..:|.|.|.|.     |.|   ||...|||| ||  .:|..
 Frog   433 L-KFVESTVDHEDGVSSSDFDFAVSNFVDNLYGYTEGKDILRE---TIKFMYTDWADR--NNPET 491

  Fly   497 TRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYV 561
            .|.|.:|..:|.|:|||.|...|:           .|..|||                  .|||.
 Frog   492 RRKTLLALFTDHQWVAPAVATADL-----------HSNFGSP------------------TYFYA 527

  Fly   562 FDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNP 626
            |.:..:....|......||:::||:||.|::.....||.|::|::..||..||.:|||||:||:|
 Frog   528 FYHHCQTDQVPAWADASHGDEIPYVFGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDP 592

  Fly   627 NEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRA 691
            |:...||:.. :..:.|||..:.|..|....|.||.||:|||:|.|:||.::::||.|:|.||
 Frog   593 NQPVPQDTKF-IHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRATKVNLWLELVPRLH-- 654

  Fly   692 GMEDVIARHNLFRNHDDMDLYEGPVKPDPFGISTAAGASGSSSSSSSSSRLLLVDEQLMMKKGRG 756
            .|.|                           ::|..|.|...:|..:.|..:.|.
 Frog   655 VMND---------------------------LTTTKGPSTDITSKPTGSNTVPVT---------- 682

  Fly   757 LNGSAYLNGILGVTTVEPNNMYTTCIPIGGNYSSSGGVFAPTTLANASSDTLASGFEAAGYAAYS 821
               ||:       .||..:|.                      ....||.:|...        ||
 Frog   683 ---SAF-------PTVSEDNF----------------------KQKPSSISLERD--------YS 707

  Fly   822 TALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLEVKTLQKQYQQRSLHQQVPYPPE----PIKHA 882
            |.||||||:|.|||.||:|.||.:||::||.|.:|.  ::...||:....:.:..|    .::..
 Frog   708 TELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVH--RRCSPQRTTANDIAHAQEEEIMSLQMK 770

  Fly   883 HYHMGHSQSS 892
            |..:.|...|
 Frog   771 HTDLDHECES 780

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	232/703 (33%)
nlgn1	XP_017949302.2	COesterase	52..646	CDD:395084	232/703 (33%)