Protein Alignment CG4465 and Slc22a2

DIOPT Version :10

• Sequence 1: NP_650847.1
• Gene: CG4465 / 42374
• FlyBaseID: FBgn0038750
• Length: 577
• Species: Drosophila melanogaster
• Sequence 2: NP_113772.1
• Gene: Slc22a2 / 29503
• RGDID: 61936
• Length: 593
• Species: Rattus norvegicus
• Alignment Length: 573
• Identity: 121/573 - (21%)
• Similarity: 211/573 - (36%)
• Gaps: 149/573 - (26%)

  Fly    59 DDVITHIMGNFGPWQLRSLLILFL----------------------CKIPAA--------WFMAC 93
            ||::.|| |.|..:|.::..:|.|                      |..|.|        |..|.
  Rat     5 DDILEHI-GEFHLFQKQTFFLLALLSGAFTPIYVGIVFLGFTPDHHCWSPGAAKLSQRCGWSQAE 68

  Fly    94 IL-FTAPDLYPEEE---------YKCD---TTAFGPDVNSTVSLDHCYVMVNYGESAYAMRQCRK 145
            .| :|.|.|.|.:|         |:.|   :|....|..|:::.|...:.:...|..:
  Rat    69 ELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLAADRNQLPLGPCEHGW------- 126

  Fly   146 FLYTTGFHSLTMEFDLVC----LCDFFVAWSQYWHLFGLLIGGVAATKLMRVLSPRQIYRTGIWC 206
             :|.|...|:..||:|||    :.|.|.:........|.::.|..|.:..|.           :|
  Rat   127 -VYNTPGSSIVTEFNLVCAHSWMLDLFQSVVNVGFFIGAMMIGYLADRFGRK-----------FC 179

  Fly   207 LLMCSL-------LMGLVKDFSLHCGLRCLAAVSCCFMITSGQYIFGDITAGK-----YRVGTLI 259
            ||:..|       ||.:..:::.....|.|..     :::...::.|.|...:     ||....|
  Rat   180 LLVTILINAISGALMAISPNYAWMLVFRFLQG-----LVSKAGWLIGYILITEFVGLGYRRMVGI 239

  Fly   260 LYDCFWALGLILLPGLASNAPSWQHIYLGVTLSLLVIVFLLPWTPDSPRWQLQHTKEAQLAIERT 324
            .|...:.:||::|.|:|...|:|:.:...|||.....:......|:||||.:...|     |.:.
  Rat   240 CYQIAFTVGLLILAGVAYVIPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNK-----IVKA 299

  Fly   325 VGILLEAARTNGRMHKVSKELPQQLEELRE-----RMLEP-------MPAVH-----WMHLWMGQ 372
            :.|:...|:.||      |.:|..|:.|..     :.|:|       .|.:.     .|:.|.
  Rat   300 MKIIKHIAKKNG------KSVPVSLQNLTPDEDAGKKLKPSILDLVRTPQIRKHTLILMYNWF-- 356

  Fly   373 RRSTFHLVAVHMALATFMVVNTGLLLHVRSFGREHLVSNTLAMGLAEMLGCFLALHLTFNLSERK 437
                           |..|:..||::|:...| :::..:.....|.|....|:.: ||.:...|:
  Rat   357 ---------------TSSVLYQGLIMHMGLAG-DNIYLDFFYSALVEFPAAFIII-LTIDRVGRR 404

  Fly   438 WQWA-GGFAIVVGCIGSICWFLAEEDMPEVYGLTLGLLMASLPQAAVACAQSMILACLGELVPME 501
            :.|| ........|:.|:   ...:|:.     .|.:.:|.|.:..:..|..|:.....||.|..
  Rat   405 YPWAVSNMVAGAACLASV---FIPDDLQ-----WLKITIACLGRMGITMAYEMVCLVNAELYPTY 461

  Fly   502 QRS-----CLSF----SAVTWARVWQLSASFLTLLRQVSPALSLSAFCLLVIL 545
            .|:     |.|.    ..:|...|::|:..::.....|...:.|.|..|:::|
  Rat   462 IRNLGVLVCSSMCDIGGIITPFLVYRLTDIWMEFPLVVFAVVGLVAGALVLLL 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4465	NP_650847.1	MFS_SLC22	143..553	CDD:340875	94/446 (21%)
Slc22a2	NP_113772.1	2A0119	12..525	CDD:273328	117/565 (21%)
		Proline-rich sequence. /evidence=ECO:0000250|UniProtKB:O15244	284..288		2/3 (67%)