Protein Alignment RhoGAP92B and Arhgap17

DIOPT Version :10

• Sequence 1: NP_650844.1
• Gene: RhoGAP92B / 42371
• FlyBaseID: FBgn0038747
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_653112.2
• Gene: Arhgap17 / 70497
• MGIID: 1917747
• Length: 846
• Species: Mus musculus
• Alignment Length: 838
• Identity: 223/838 - (26%)
• Similarity: 383/838 - (45%)
• Gaps: 148/838 - (17%)

  Fly     1 MKRQFAKIK-IAAENLSRSSKSDSKDSELEAIERQVDRYRDTIEKIVRKLPA-LSGGGGSGSGSS 63
            ||:||.::| :|.:.:.|:.|::....:|..|||::|..|.......::|.| ..|..|:
Mouse     1 MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSMCHHSHKRLIACFQGQHGT----- 60

  Fly    64 EEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRRL 128
             :.::|.||.....:||.:.|::.:|.:.: |.|:|..||:.|..:|..:.:.|:..|.:::..|
Mouse    61 -DAERRHKKLPLTALAQNMQEASAQLEESL-LGKMLETCGDAENQLALELSQHEVFVEKEIMDPL 123

  Fly   129 KNILDKEIQEISTLKRNVSRTLQEYTSLK----RSHEAA-IRLEEPAAKVNHIKSQQEECELKLE 188
            ..|.:.||..|...::.::|.:.::.|::    ::|::: ...:...:|::.:|.:.:|...|:|
Mouse   124 YGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEMDEAGNKVE 188

  Fly   189 KERDAWAAQMLELIAKEDEIVSCIRDYVLNQRNYHERALQHVNASLARI---QDTIQGTEKSRFG 250
            :.:|..||.|...:|||.|........:..|.:||.:||..:..:|..:   ||  :..||..||
Mouse   189 QCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKALPEMRAHQD--KWAEKPAFG 251

  Fly   251 TSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLPLDY 315
            |.|:|||..:.|||:..:|.|...|||.|::||||.|:|..::||:::|.||:..  .:.|...|
Mouse   252 TPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCS--TSHLDEFY 314

  Fly   316 QDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLPKENYANLRYLT 380
            .|||.:...||.|||||||||:|::||:::.::|....:.::...:.....|||.:|:.|.|||.
Mouse   315 SDPHAVAGALKSYLRELPEPLMTFSLYEEWTQVASVQDQDKKLQYLWTTCQKLPPQNFVNFRYLI 379

  Fly   381 RFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANI--IVELLISQ 443
            :||:.:.|.|.:|||:..|:|||:.||:||.:.:.:       :.::.::::.::  ::|.:|..
Mouse   380 KFLAKLAQTSDVNKMTPSNIAIVLGPNLLWAKQEGT-------LAEIAAATSVHVVAVIEPIIQH 437

  Fly   444 WDYFFIGEVEFYLTLQKQKLFVEGKSKSNSSNENLDRNDSE-------------VMESP------ 489
            .|:||.|||||.::    :.||. .:..||::.:...|||:             |||..
Mouse   438 ADWFFPGEVEFNVS----EAFVP-LATPNSNHSSHTGNDSDSGTLERKRPASMAVMEGDLVKKES 497

  Fly   490 ------------RYGTLRRQ---KANAPSPPTTNGNGIIMTTSQTSHRPHAKELFPQQTPEKQEK 539
                        |.|||.|:   .|..|..|.|:||.:         .|...|. |.|:......
Mouse   498 FGVKLMDFQAHRRGGTLNRKHIAPAFQPPLPPTDGNAL---------APAGPEP-PSQSSRADSS 552

  Fly   540 PAKPPLPN----LPQFQSPAASQPTQTQLEPLPPPPVTPAKPVPMTRTQFFGLDNLPSPTADRKS 600
            ....|:.:    |.|..||..|.|      |.|...|:.|.|..       |.::....|...::
Mouse   553 SGGGPVFSSTGILEQGLSPGDSSP------PKPKDSVSAAVPAA-------GRNSNQMTTVPNQA 604

  Fly   601 TDSIGSFKLKPDVP---------------QKPL-LPKRPTVLGVGVPKADGKSDDEGGTTPTQAT 649
            .....|.:|....|               :||. .|.:|..|..|.|  .|:|....||:|..:.
Mouse   605 QTGGNSHQLSVSTPHSAAGPSPHTLRRAVKKPAPAPPKPGNLPPGHP--GGQSSPGTGTSPKPSA 667

  Fly   650 IDNGNGSVRFKTEHFLDKLRQENGETNGTREVSST---TKENNHNHDPPATAADQNQQQAQPQVT 711
              ......:.:.:....:.:|:..:|.|.|..||:   .:..:|....|.|.....:|..:|..|
Mouse   668 --RSPSPPQQQQQQQQQQQQQQQQQTPGMRRCSSSLPPIQAPSHPPPQPPTQPRLGEQGPEPGPT 730

  Fly   712 TPISPNSFQTP-----------------------------KRPTVPAPPPPTNWKSSD 740
            .|.:|....||                             .||:||.||.|....:.|
Mouse   731 PPQTPTPPSTPPLAKQNPSQSETTQLHGTLPRPRPVPKPRNRPSVPPPPHPPGTHTVD 788

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_650844.1	BAR	27..257	CDD:472257	62/238 (26%)
		RhoGAP_nadrin	245..452	CDD:239851	78/208 (38%)
		PRK13855	495..>650	CDD:172376	40/177 (23%)
Arhgap17	NP_653112.2	BAR_Rich1	13..257	CDD:153302	63/252 (25%)
		RhoGAP_nadrin	246..446	CDD:239851	78/208 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	459..482		5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..807		63/297 (21%)
		SH3-binding. /evidence=ECO:0000255	730..743		5/12 (42%)