Protein Alignment RhoGAP92B and Fam13a

DIOPT Version :10

• Sequence 1: NP_650844.1
• Gene: RhoGAP92B / 42371
• FlyBaseID: FBgn0038747
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_705802.1
• Gene: Fam13a / 58909
• MGIID: 1889842
• Length: 693
• Species: Mus musculus
• Alignment Length: 694
• Identity: 124/694 - (17%)
• Similarity: 216/694 - (31%)
• Gaps: 278/694 - (40%)

  Fly   135 EIQEIST----LKRNVSRTLQEYT-SLKRSHEAAIRLEEPA-AKVNHIKSQQEECELKLEKERDA 193
            ::..:||    |:|.:...::|:. .:..:.:.:....||. :..:.|.::|...:.|  |:.|.
Mouse    29 QVSNVSTTGELLERTIRSAVEEHLFDVSNAGDQSSEDSEPGPSSASSIPTRQRGHQFK--KQDDV 91

  Fly   194 WAAQMLELIAKED------EIVSCIR-------------DYVLNQRNYHERALQHVNASLARIQD 239
            |.....|||.||:      ....||.             ||| .:|:..:|  |..::.||::.|
Mouse    92 WHGCDKELINKENIPSGFSGCAECILNSQEAERFQDDICDYV-GERSKPKR--QKSSSRLAKLSD 153

  Fly   240 TIQGTEKSRFGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEA 304
            ...|.......:|::...|                     ||.|....:...|.::.|  ...:.
Mouse   154 NHDGALSMESLSSMQSQET---------------------LEPEAAEPLSSESKEIER--GGRDT 195

  Fly   305 QHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLP 369
            ||.:.|.                                  ::|.|..|.::.|
Mouse   196 QHCENPT----------------------------------MKIQEHPSLSDTK----------- 215

  Fly   370 KENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRID-------KSSNAPADYIGQV 427
                             |||:...:...::..    |:|  |::|       |:...|
Mouse   216 -----------------QQRNQDGEDQQESFV----PDM--PQLDLTALCDEKTWEEP------- 250

  Fly   428 NSSSAANIIVELLISQWDYFFIGEVEFYLTLQKQKLFVEGKSKSNSSNENLDRNDSEVMESPR-- 490
                         |..|........|..|:.|..:|.          ::.|| .||:.|.|||
Mouse   251 -------------IPSWQPENADSDEARLSPQAGRLI----------HQFLD-EDSDPMLSPRFY 291

  Fly   491 -YGTLRRQKANA---PSPPTTNGNGIIMTTSQTSHRPHAKELFPQQ------------------- 532
             ||..|:...:.   ||||.::......::|..|:....::|.|.|
Mouse   292 AYGQSRQYLDDTEVPPSPPNSHSFMRRRSSSLGSYDDEQEDLTPVQLTRRIQTLKKKIRKFEDRF 356

  Fly   533 ------TPEKQEKPAKPPL----PNLPQFQSPAASQPTQTQLEPLPPPPVTPAKPVPMTRTQFFG 587
                  .|...:|.|.|.:    .:|.:|:........:...|.|          .|.||.:
Mouse   357 EEERKYRPSHSDKAANPEVLKWTNDLAKFRKQLKESKLKISEEDL----------TPRTRQR--- 408

  Fly   588 LDNLPSPTADRKSTDSIGSFKLKPDVPQKPLLPK--RPTVLGVGVPKADGKSDDEGGTTPTQATI 650
            .:.||.         |.||...|.|..::.||.|  ||:|                     :||:
Mouse   409 SNTLPK---------SFGSQLEKEDEKKQELLDKAIRPSV---------------------EATL 443

  Fly   651 DNGNGSVRFKTEHFLDKLRQENGETNGTREVSSTTKENNHN---------------HDPPATAAD 700
                       |..|.||:::..|::...::...||:...|               |..|.|..:
Mouse   444 -----------EGILRKLQEKRVESSRPEDIKDMTKDQIANEKVALQKALLYYESIHGRPVTKTE 497

  Fly   701 QNQQQAQPQVTTPISPNSFQTPKR-----PTVPAPPPPTNWKSS 739
            :       |:..|:. :.::..|:     .|||....|::.:.|
Mouse   498 R-------QIMKPLY-DRYRLVKQILSRASTVPIIGSPSSKRRS 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_650844.1	BAR	27..257	CDD:472257	31/146 (21%)
		RhoGAP_nadrin	245..452	CDD:239851	25/213 (12%)
		PRK13855	495..>650	CDD:172376	35/188 (19%)
Fam13a	NP_705802.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	56..89		6/34 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	136..233		25/187 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	302..331		6/28 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	396..424		11/49 (22%)