Protein Alignment RhoGAP92B and arhgap25

DIOPT Version :10

• Sequence 1: NP_650844.1
• Gene: RhoGAP92B / 42371
• FlyBaseID: FBgn0038747
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: XP_005165226.1
• Gene: arhgap25 / 562468
• ZFINID: ZDB-GENE-060526-210
• Length: 647
• Species: Danio rerio
• Alignment Length: 659
• Identity: 156/659 - (23%)
• Similarity: 258/659 - (39%)
• Gaps: 142/659 - (21%)

  Fly   116 SELETEAKVVRRLKNILDKEIQEIST---LKRNVSRTLQE-YTSLKRSHEAAIRLEEPAAKVNHI 176
            |....|...:.|.|:::..|....||   .|:::.:.|:. :...:||.....:|.....:.|.:
Zfish    12 STFRAETAKIARSKSVIPGEGSPASTHSGFKKSMEKPLKTGWLKKQRSIVKNWQLRFFVLRGNSL 76

  Fly   177 KSQQEECELKLEKERDAWAAQMLELIAKED-----EIVSC------IRD-YVLNQRNYHERALQH 229
            ...:::.|..::.....::.|:.||.:..|     ||:..      .|| |||...:..|
Zfish    77 TYHKDDKESTVQGTIPLFSCQVNELPSNADDKFLFEIIPAGGSTDRERDAYVLMATSQSE----- 136

  Fly   230 VNASLARIQDTIQGTEKSRFGTSLKEHLTSTN----REISYIVELCCCCLLEHGLEEEGLLRVGC 290
            :...:..|:..|.......||.||.:.:....    |.:..:||.|...:.||||.|||:.|:..
Zfish   137 MEEWVRWIRKAIGSRSNGVFGKSLSDIMVYERKFGARLVPILVEKCAEFIREHGLVEEGIFRLPG 201

  Fly   291 ASTKLRRMKHALEAQHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFI--RIAERHS 353
            ...::::.:.|.:|.. :...|.| .|.|.:.|:|||||||||||::.:..|:||:  .:....:
Zfish   202 QDNQVKQFREAFDAGE-RPSFPSD-TDVHTVASLLKLYLRELPEPVVPWTQYQDFLDSTLMLDAT 264

  Fly   354 EAERKTEIKAILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSN 418
            .|..|.:::..::.|||.||..|.|:.|||..|||.|.:||||.:|||.||..|:..|:::
Zfish   265 TAAGKEKLEKQISLLPKVNYNLLSYICRFLFEVQQNSKVNKMSVENLATVMGVNLFKPQVE---- 325

  Fly   419 APADYIGQVNSSSAANIIVELLISQWDYFFIGEVEFYLTLQKQKLFVEGKSKSNSSNENLDRNDS 483
               |.|..:..:.....::.::|...:..|....:     .|.......|:||..::.:....:|
Zfish   326 ---DAISMMKGTPMIQKVMTVMIRHHELLFPPSKD-----MKPSPLPSRKNKSKKTSNSFVGWES 382

  Fly   484 EVMESPRYGTLRRQKANAPSPPTTNGNGIIMTTSQTSHRPHAKELFPQQTPEKQEKPAKPPLPNL 548
            ...|                            .|..|..|..:|:   .|||:|.|..:
Zfish   383 AECE----------------------------VSSLSESPEEEEV---DTPEEQRKELR------ 410

  Fly   549 PQFQSPAASQPTQTQLEPLPPPPVTPAKP-VPMTRTQFFGLDNLPS------------PTADR-- 598
                   :|:...|.|.|......|...| .|..|||     .|||            |..||
Zfish   411 -------SSESESTTLSPTEFSVTTDTWPESPRKRTQ-----TLPSLGCPPVARIAREPAWDRWS 463

  Fly   599 ---KSTDSIGSFKLKPDVPQKPLLPKRPTVLGVGVPKADGKSDDEGGTTPTQATIDNGNGSVRFK 660
               :|.:......|..|:.:  ||..:...|...|.|::.:.:::|     |...||.:.|   |
Zfish   464 RFPESFNENDEKTLSEDIFK--LLDLQKVTLFSEVQKSENEKEEKG-----QKDKDNTDWS---K 518

  Fly   661 TEHFLDKLRQENGETNGTREVSSTTKENNHNHDPPATAADQNQQQAQPQVTTPISP--NSFQTPK 723
            |:.  |.:.|:                    .|.|...|.......:||....:||  :|.:.|.
Zfish   519 TDS--DVVVQQ--------------------IDAPKAQAQNTAPVPKPQARIVLSPAASSKENPA 561

  Fly   724 RPTVPAPPP 732
            :.|..|..|
Zfish   562 QQTSSAVQP 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_650844.1	BAR	27..257	CDD:472257	32/156 (21%)
		RhoGAP_nadrin	245..452	CDD:239851	68/212 (32%)
		PRK13855	495..>650	CDD:172376	35/172 (20%)
arhgap25	XP_005165226.1	PH-like	46..155	CDD:473070	20/113 (18%)
		RhoGAP_ARHGAP22_24_25	154..352	CDD:239855	67/206 (33%)
		SIKE	<556..>601	CDD:461735	5/15 (33%)
		PRK09039	<583..>637	CDD:181619