Protein Alignment RhoGAP92B and Arhgap25

DIOPT Version :10

• Sequence 1: NP_650844.1
• Gene: RhoGAP92B / 42371
• FlyBaseID: FBgn0038747
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_001102717.1
• Gene: Arhgap25 / 500246
• RGDID: 1562105
• Length: 648
• Species: Rattus norvegicus
• Alignment Length: 550
• Identity: 128/550 - (23%)
• Similarity: 216/550 - (39%)
• Gaps: 130/550 - (23%)

  Fly   130 NILDKEIQEISTLKRN---VSRTLQEYTSLKRSHEAAIRLEE----------PAAKVNHIKSQQE 181
            |.|::.| ::..||:.   |....|.|..||.......:.||          |.:.|..|.:..|
  Rat    42 NPLERPI-KMGWLKKQRSIVKNWQQRYFVLKARQLYYYKDEEDSKPQGCMYLPGSTVKEIATNPE 105

  Fly   182 ECELKLEKERDAWAAQMLELI-AKEDEIVSCIRDYVLNQRNYHERALQHVNASLARIQDTIQGTE 245
            |.           ...:.|:| |..|:..:....|||...:..|  ::.....|.|:..|..|
  Rat   106 EA-----------GKFVFEVIPASSDQNRTGQDSYVLMASSQVE--MEEWVKFLRRVAGTPSG-- 155

  Fly   246 KSRFGTSLKE----------HLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKH 300
             :.||..|.|          ||      :..:||.|...:||||:.|||:.|:......:::::.
  Rat   156 -AVFGQRLDETVAYEQKFGPHL------VPILVEKCSEFILEHGVSEEGIFRLPGQDNLVKQLRD 213

  Fly   301 ALEAQHVKTPLPLDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAE--RHSEAERKTEIKA 363
            |.:|.. :.....| .|.|.:.|:||||||:||||::.::.|:.|:...:  ...||:.:.|::.
  Rat   214 AFDAGE-RPSFDRD-TDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELEK 276

  Fly   364 ILTKLPKENYANLRYLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRID-------------- 414
            .|:.||::||..|.|:.|||..:|...|:||||..|||.|:..|::..:::
  Rat   277 QLSILPRDNYNLLSYICRFLHEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQR 341

  Fly   415 --------------KSSNAPADYIGQVNSSSAANIIVELLISQWDYFFIGEVEFYLTLQKQKLFV 465
                          ||.:||.....|.|.:..|.:....:  .||           ..:...|
  Rat   342 VMTMMIRDHEVLFPKSKDAPLSPPAQKNDAKKAPVPRSSV--GWD-----------ATEDPPL-- 391

  Fly   466 EGKSKSNSSNENLDRNDSEVMESPRYGTLRRQKANAPSPPTTNGNGIIMTTSQTSHRPHAK---- 526
               |:::|.|......|:.....|:.|. :.|:.:..:|....|:..:.:..:|...|:.|
  Rat   392 ---SRTDSFNNTASSPDATSPTGPQPGD-QHQEDSGKAPKENPGDWKMQSRKRTQTLPNRKCFLT 452

  Fly   527 -----------ELFPQQ--TPEKQEKPAKPPLPNLPQFQSPAASQPTQTQLEPLPPPPVTPAKPV 578
                       |:|..:  :|..:.|..:.....:.|.....::....:..:.:|.|||:...|.
  Rat   453 SAFQGTTSSKLEIFKNEFWSPSSEAKAGEGHRRTMSQDLRHLSNDQRTSTYDNVPNPPVSQGNPA 517

  Fly   579 PMTRTQFFGLDNLPSPTADRK-----STDS 603
                      ..|..|.:|.|     ||||
  Rat   518 ----------GELSPPASDSKRDAPVSTDS 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_650844.1	BAR	27..257	CDD:472257	33/150 (22%)
		RhoGAP_nadrin	245..452	CDD:239851	68/246 (28%)
		PRK13855	495..>650	CDD:172376	23/130 (18%)
Arhgap25	NP_001102717.1	PH_RhoGap25-like	45..157	CDD:270083	27/128 (21%)
		RhoGAP_ARHGAP22_24_25	156..354	CDD:239855	59/205 (29%)
		PRK03918	544..>645	CDD:235175