Protein Alignment RhoGAP92B and Prune2

DIOPT Version :10

• Sequence 1: NP_650844.1
• Gene: RhoGAP92B / 42371
• FlyBaseID: FBgn0038747
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: XP_006527207.1
• Gene: Prune2 / 353211
• MGIID: 1925004
• Length: 3087
• Species: Mus musculus
• Alignment Length: 793
• Identity: 143/793 - (18%)
• Similarity: 247/793 - (31%)
• Gaps: 305/793 - (38%)

  Fly    14 NLSRSSKSDSKDSELEAIE---------RQVDRYRDTIEKIVRKLPALSGGGGSGSGSSEEQDKR 69
            |.|.:|..:..:.|:||::         |..|  .||.|
Mouse  2182 NTSVTSMEEDTNPEVEAVDSVTIPGHFPRSED--ADTFE-------------------------- 2218

  Fly    70 TKKNSHYKIAQALDES--AKEL-PKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRRLKNI 131
                :|.:::..:|:|  :|:| |:.....:.|.:|.:...:.:..::.....|....:...:..
Mouse  2219 ----AHQEVSVEVDDSWVSKDLCPESQTGTRALLDCEQPFASESPAVLTDIFLTSDTCLDVSEAA 2279

  Fly   132 LDKEIQEISTLKRNVSRTLQEYTSLKRSHEAAIRLEEPAAKVNHIKSQQEECELKL---EKERDA 193
            ||....:.|.|..:.. |:.:.:.|..|.      ..|...|:....:|:.|..:.   :.|.||
Mouse  2280 LDHSFSDASGLNTSTG-TIDDMSKLTLSE------GHPETPVDGDAGKQDVCSSEASWGDFEYDA 2337

  Fly   194 WAAQMLELIAKEDEIVSCIRDYVLNQRNYHERALQHVNASLARIQDTIQGTEKSRFGTSLKEHLT 258
            ....:.|.:.:|.|                     |.          :.|.:.....::||:.||
Mouse  2338 MGQNIDEELMREPE---------------------HF----------LYGGDLPSEESALKQSLT 2371

  Fly   259 --STNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLPLDYQDPHVI 321
              :...::||:.|                 ..||..|          ||..::|     .|..:.
Mouse  2372 PYTPPFDLSYLTE-----------------PTGCTET----------AQGAESP-----GDESLG 2404

  Fly   322 GSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLPKENYANLRYLTRFLSIV 386
            ....::.|..||:                 |.| |.|.|          .|....||....|.|.
Mouse  2405 SDAAEMLLSALPD-----------------HRE-EDKAE----------TNIRKPRYQMTVLHIH 2441

  Fly   387 QQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANIIVELLISQWDYFFIGE 451
            :...||                         ::|....|..|.||.:||       .|      |
Mouse  2442 EDPEAL-------------------------SSPVGGTGSNNESSPSNI-------DW------E 2468

  Fly   452 VEFYLTLQKQKLFVEGKSKSNSSNENLDRNDSEVMESPRYGTLRRQKANAPSPPTTNGNGIIMTT 516
            :|                        .|.:|     ||..|.::        ||  ||..|:...
Mouse  2469 IE------------------------TDNSD-----SPAGGDMK--------PP--NGKEILELE 2494

  Fly   517 SQTSHRP----------HAKELFPQQTPEKQ-------------EKPAKPPL----PNLPQF-QS 553
            ......|          :.:|..|:|:.:.|             :.|.||..    .|:|:. |.
Mouse  2495 EDEKVIPTKGPKQTELEYKEEKQPEQSEDHQVLAVDYILVSHEKDSPLKPEAREARENIPELEQL 2559

  Fly   554 PAASQPT---QTQLEPLPPPPVTPAKPVPMTRTQFFGLDNLPSPTADRKSTDS-IGSFKLKPDVP 614
            ...|:.|   :|||...|          ...:::|  |:::...:|:|.|:.| ..|..|
Mouse  2560 SIGSRETGLPETQLSGTP----------DTCQSEF--LNDVKVHSAERMSSSSNHESASL----- 2607

  Fly   615 QKPLLPKRPTVLG---VGVPKADGKSDDEG----GTTP---TQATIDNGNGSVRFKTEHFLDKLR 669
            :.|...:...||.   ||.|..:.:  |.|    |.||   ...::|.|..|...:....|:.|.
Mouse  2608 ENPAQDQSWMVLSHSEVGDPPTETR--DSGPESPGRTPEPFLSLSLDKGPKSQVLERNKPLNSLA 2670

  Fly   670 QEN--GETNGTREV---------SSTTKENNHNHD-----PPATAADQNQQQAQPQVTTPISPNS 718
            .|.  |.::.:|.:         :..|:...|:::     |..:..::|..|...:.|....|.
Mouse  2671 LEEVAGLSSQSRNIERQGQAGLDAVPTQAATHDNEWEMLSPQLSRKNRNPPQEMEEETQCPEPG- 2734

  Fly   719 FQTPKRPTVPAPP 731
               |::|.:..||
Mouse  2735 ---PRKPRLKGPP 2744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_650844.1	BAR	27..257	CDD:472257	38/244 (16%)
		RhoGAP_nadrin	245..452	CDD:239851	37/208 (18%)
		PRK13855	495..>650	CDD:172376	41/196 (21%)
Prune2	XP_006527207.1	DHHA2	214..>277	CDD:460719
		BNIP2	2782..2892	CDD:463609
		CRAL_TRIO_2	2904..3041	CDD:463965