Protein Alignment RhoGAP92B and arhgap17b

DIOPT Version :10

• Sequence 1: NP_650844.1
• Gene: RhoGAP92B / 42371
• FlyBaseID: FBgn0038747
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: XP_009297597.1
• Gene: arhgap17b / 100141341
• ZFINID: ZDB-GENE-080220-26
• Length: 790
• Species: Danio rerio
• Alignment Length: 801
• Identity: 219/801 - (27%)
• Similarity: 370/801 - (46%)
• Gaps: 144/801 - (17%)

  Fly     1 MKRQFAKIK-IAAENLSRSSKSDSKDSELEAIERQVDRYRDTIEKIVRKL-PALSGGGGSGSGSS 63
            ||:||.::| :|.:.:.|:.|::....:|..|||:::..|.....:.:|: ..|.|..|:
Zfish     2 MKKQFNRMKQLANQTVGRAEKTEVLSDDLLLIERRLENVRLVSHNVHKKMVMCLQGNVGT----- 61

  Fly    64 EEQDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRRL 128
             :.:||.||.....::|::.|...:|.::..:.|::..||:.|..:|....:.|:..|..::..|
Zfish    62 -DAEKRHKKLPLMILSQSMVEGVAQLGEESLIGKMMDICGDAENKLAFEQSQHEVLLEKDILDPL 125

  Fly   129 KNILDKEIQEISTLKRNVSRTLQEYTSLK-RSHEA------AIRLEEPAAKVNHIKSQQEECELK 186
            ..:.:.:|..|...:|::::.:.:|.|.| |.|:|      |...:..||||:.:|.:.:|.:.:
Zfish   126 NQLAEVDIPNIQKQRRHLAKLVLDYDSAKGRYHQATKSFPSATNAQAMAAKVDMLKEEMDEAQNR 190

  Fly   187 LEKERDAWAAQMLELIAKEDEIVSCIRDYVL---NQRNYHERALQHVNASLARIQ-DTIQGTEKS 247
            :|..:|..||.|....:||.|..   |.|||   .|..||.|||..:.:.|..|| ...:..||.
Zfish   191 MEICKDQVAADMYSFASKEGEYA---RYYVLLLEAQAEYHRRALASIESVLPNIQSQQDKWMEKP 252

  Fly   248 RFGTSLKEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLP 312
            .|||:|:|||..|.||::..:|.|...|||.|::||||.|:...::||:::|.||:..  .:.|.
Zfish   253 AFGTALEEHLKRTGREVALPIEACVMMLLETGMQEEGLFRIAAGASKLKKLKAALDCS--TSQLE 315

  Fly   313 LDYQDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLPKENYANLR 377
            ..|.|||.:...||.|||||||||::|.||:::|:.:......:|...:..:...|||.|..|.|
Zfish   316 EFYSDPHAVAGALKSYLRELPEPLMSYQLYEEWIQASNISDPDKRLQALWVVCDMLPKANKTNFR 380

  Fly   378 YLTRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANI--IVELL 440
            ||.:||:.:...|.:|||::.|:|||:.||:||.:.:.|       :.::.::::.::  |:||:
Zfish   381 YLVKFLAKLALESDVNKMTASNIAIVLGPNLLWAKTEGS-------LAEMAATTSVHVVSIIELI 438

  Fly   441 ISQWDYFFIGEVEF------------------YLTLQKQKLFVEGKSKSNSSNENLDRNDSEVME 487
            |:...:||.|:|:|                  |.|:::::...:|...|:::.::...|......
Zfish   439 INHAGWFFPGDVDFNVSGVFAMPGCPGTPDVEYGTIERRRPGSQGSLDSDTARKDSPANKQPEFA 503

  Fly   488 SPRYGTLRRQKANAPS-----PPTTNGNGIIMTTSQTSHRPHAKELFPQQTPEKQEKPAKPPLPN 547
            ..|.||:.:::.:.|:     ||...|.|....:.........:.|..|||
Zfish   504 PRRTGTITKKQHSTPNFQPPLPPIEAGGGSAFESCPQLPAAGLEALQTQQT-------------- 554

  Fly   548 LPQFQSPAASQPTQTQLEPLPPPPV----------TPAKPVPMTRTQFFGLDNLPSPTADRKSTD 602
            |.| ||||:...:.:..:.:..||.          ||| |..::..........|||...|:.|
Zfish   555 LVQ-QSPASDNSSLSSRDSVSTPPTMRNGPGGSSGTPA-PAQLSVGTPTSSPKGPSPFMVRRGT- 616

  Fly   603 SIGSFKLKPDVPQKPLLP-KRPTVLGVGVPKADGKSDDEGGTTPTQATIDNGNGSVRFKTEHFLD 666
                 |.:...|.||.:| ..|:|      ||          ||.| .|.|..
Zfish   617 -----KKQAPAPPKPSVPATSPSV------KA----------TPNQ-PISNPY------------ 647

  Fly   667 KLRQENGETNGTREVSSTTKENNH------NHDPPATAAD--QNQQQAQPQ-VTTPISP-----N 717
                   .|.||.:.....:..|.      :|.||...:.  .:.::|.|. ..||..|     :
Zfish   648 -------STPGTPQPLIAPRRTNQTPIQAPSHPPPQPPSQPPSHTEEAVPSPPRTPTPPGTPPHD 705

  Fly   718 SFQTPKRPT-----VPAPPPP 733
            |.|:..|||     .|:.|||
Zfish   706 SSQSRPRPTPRSRPKPSGPPP 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_650844.1	BAR	27..257	CDD:472257	68/241 (28%)
		RhoGAP_nadrin	245..452	CDD:239851	79/208 (38%)
		PRK13855	495..>650	CDD:172376	38/170 (22%)
arhgap17b	XP_009297597.1	BAR_Rich1	14..261	CDD:153302	69/255 (27%)
		RhoGAP_nadrin	250..450	CDD:239851	79/208 (38%)
		PHA03247	<459..659	CDD:223021	51/257 (20%)