Protein Alignment RhoGAP92B and sh3bp1

DIOPT Version :10

• Sequence 1: NP_650844.1
• Gene: RhoGAP92B / 42371
• FlyBaseID: FBgn0038747
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: XP_021329927.2
• Gene: sh3bp1 / 100006678
• ZFINID: ZDB-GENE-121128-2
• Length: 670
• Species: Danio rerio
• Alignment Length: 700
• Identity: 190/700 - (27%)
• Similarity: 313/700 - (44%)
• Gaps: 113/700 - (16%)

  Fly     1 MKRQFAKIKIAAENLSRSSKSDSKDSELEAIERQVDRYRDTIEKIVRKLPALSGGGGSGSGSSEE 65
            |.:||..:|...........:|....:|..:|::|:..:...:.|.:||.     |...|....:
Zfish     1 MLKQFNILKQFGNGGKSQDATDLLTEDLVLVEQRVEPAKKAAQIIHKKLV-----GCLQSQQGLD 60

  Fly    66 QDKRTKKNSHYKIAQALDESAKELPKDMPLQKVLANCGELEKTMAECIIESELETEAKVVRRLKN 130
            .::|.||.....::.::.||.|:...|..::|||..|..::.|:|:.:.:.|::.|.:|:..|..
Zfish    61 SERRMKKLPLMMLSVSMAESIKDFDGDSSIRKVLEMCCFMQNTLAQTLADFEMKLEKEVLVPLNK 125

  Fly   131 ILDKEIQEISTLKRNVSRTLQEYTSLKRSHEAAIRLEEPAAKVNHIKSQQEECELKLEKERDAWA 195
            :.::::.||...|:..::...::.:.:...|.:   ..|.||.:.::...||...:||..:|.::
Zfish   126 LSEEDLPEILKNKKQFAKLTTDWNNARTRSETS---TGPQAKQHGLREDVEEAWRRLESIKDQYS 187

  Fly   196 AQMLELIAKEDEIVSCIRDYVLNQRNYH-------ERALQHVNASLARIQDTIQGTEKSRFGTSL 253
            |.:.....|||:..|.....:..|..||       ||.:..:..|.:..:..:..:|...||..|
Zfish   188 ADLYHFATKEDDYASYFTRLLELQAEYHKASYDFLERNITELKESHSHTEPLVSSSENKVFGEPL 252

  Fly   254 KEHLTSTNREISYIVELCCCCLLEHGLEEEGLLRVGCASTKLRRMKHALEAQHVKTPLPLDY--- 315
            ..||.|..|:|:..:|.|...||..||.||||.|:..|::.::::|.:|::..|      |:
Zfish   253 LSHLQSCRRKIAVPIEECVNMLLRTGLREEGLFRLAAAASVMKKLKSSLDSGTV------DHTEF 311

  Fly   316 -QDPHVIGSILKLYLRELPEPLLTYNLYKDFIRIAERHSEAERKTEIKAILTKLPKENYANLRYL 379
             .|||.:...||.|||||||||:|:.||.|:...|......|:...::..|.|||.|||.|||||
Zfish   312 SSDPHAVAGALKCYLRELPEPLMTFELYDDWFEAAGEKETDEKLKLLRTALQKLPTENYNNLRYL 376

  Fly   380 TRFLSIVQQRSALNKMSSQNLAIVMSPNMLWPRIDKSSNAPADYIGQVNSSSAANI----IVELL 440
            .:|||.:.:..|:|||:..|:|||:.||:||||.:..::.       ::.:||:::    |:|.|
Zfish   377 IQFLSQLSEHQAVNKMTPSNIAIVLGPNLLWPRCEGETSL-------LDMASASSVQVVTIIEPL 434

  Fly   441 ISQWDYFFIGEVEFYL---------TLQKQKL---------FVEGK---SKSNSSNENLD----- 479
            |......|..|.:|.:         |..::.|         |..|:   ||::||..:.|
Zfish   435 IQHSKSLFPEEADFEVPVLPESPLSTTSQRPLSDSILPSPPFSSGRPSISKTDSSASSDDFGVTI 499

  Fly   480 --------------RNDSEVMESPRYGTLRRQKANAPSPPTTNGNGIIMTTSQTSHRPH------ 524
                          .|||:..:.|    |.:.......|..|.    ::|.||:...|.
Zfish   500 VVKSAPVNRDAVVWDNDSDPTDQP----LTQDHMPTALPRYTP----VLTPSQSQVMPQISCISE 556

  Fly   525 -AKELFPQQTPEKQEKPAKP-------PLPNLPQ--FQSPAASQPT-QTQLEPLPPPPVTPAKP- 577
             .::|..|:...|...|.||       ..||..:  ..|||.|.|| ||:|.|:|.|..:..||
Zfish   557 PTQDLPTQEPTLKIAGPYKPRRSFIQQKAPNYTKGLLVSPAMSFPTAQTKLPPVPLPRGSEIKPP 621

  Fly   578 -VPMTRTQFFGLDNLPSPTADRKSTDSIGSFKLKPDVPQKPLLPKRPTVL 626
             .|...|....|..||.....:|....      :|.||.    |:.|..|
Zfish   622 LSPKPETMLVPLPTLPEGGPPKKPQGR------RPKVPP----PQPPQAL 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RhoGAP92B	NP_650844.1	BAR	27..257	CDD:472257	52/236 (22%)
		RhoGAP_nadrin	245..452	CDD:239851	81/214 (38%)
		PRK13855	495..>650	CDD:172376	39/150 (26%)
sh3bp1	XP_021329927.2	BAR_SH3BP1	12..249	CDD:153304	50/244 (20%)
		RhoGAP	244..446	CDD:470621	81/214 (38%)
		PHA03247	<443..650	CDD:223021	50/220 (23%)