Protein Alignment Ask1 and STE11

DIOPT Version :10

• Sequence 1: NP_477089.3
• Gene: Ask1 / 42366
• FlyBaseID: FBgn0014006
• Length: 1363
• Species: Drosophila melanogaster
• Sequence 2: NP_013466.1
• Gene: STE11 / 851076
• SGDID: S000004354
• Length: 717
• Species: Saccharomyces cerevisiae
• Alignment Length: 858
• Identity: 204/858 - (23%)
• Similarity: 331/858 - (38%)
• Gaps: 273/858 - (31%)

  Fly    94 NDIDSKQTLSLKLSCANYL--FLSYKRNAETNSCHLTSQPN-----------SGNN--------- 136
            ||:...|....::.|..||  |:         .|:|.::..           .|.|
Yeast    20 NDLPFVQLFLEEIGCTQYLDSFI---------QCNLVTEEEIKYLDKDILIALGVNKIGDRLKIL 75

  Fly   137 --SKEPNAEGRVPTLQWRLKRKLQDVEIQSKAHMR-------EK----FLSDMRTARDTYATNGA 188
              ||....:.|:..:. |||..::.|...|.|.:.       ||    |:.:..:|:........
Yeast    76 RKSKSFQRDKRIEQVN-RLKNLMEKVSSLSTATLSMNSELIPEKHCVIFILNDGSAKKVNVNGCF 139

  Fly   189 KLQSILHEMRKRLDDPHVL-----SGEVVHSFMCSLRDVQDYDAMVRLVNDLKNIPNTRKYVETG 248
            ...||...:.:||  ||.|     :|||.       :.|||||..|  ::..||:
Yeast   140 NADSIKKRLIRRL--PHELLATNSNGEVT-------KMVQDYDVFV--LDYTKNV---------- 183

  Fly   249 NMSFLYAFALNRRNRKGDREKALESSLKALEKKENHFPDMLCLCGRIYKDIFVESDYTDA-TSLA 312
             :..||...|.......||          :||.               :.|||..|.|.: .:::
Yeast   184 -LHLLYDVELVTICHANDR----------VEKN---------------RLIFVSKDQTPSDKAIS 222

  Fly   313 HAIKWYRQSFEVQPNEYAGINLATLLVIEGKEFTNTEELQHIGMTLNNLIGKKGSLSSLSEYWDV 377
            .:.|.|.::....  ...|.:.:.||.            |:.|::.||..||
Yeast   223 TSKKLYLRTLSAL--SQVGPSSSNLLA------------QNKGISHNNAEGK------------- 260

  Fly   378 ATFFEISVLANDYAKAIQAAECMFKLKPPNWYLKSTIGNISLIHRFRKKPEERQPPIEEQVFQFW 442
               ..|.....|..:.|      |..:||:.::.:.:... ..|...|:
Yeast   261 ---LRIDNTEKDRIRQI------FNQRPPSEFISTNLAGY-FPHTDMKR---------------- 299

  Fly   443 MDFFLEATNTEEVKNSIRFPILILEPQKIYMPSYVTINMDADEKSIQIVNICLAHAK---NACKK 504
                |:.|..|..::|.|..|....|            :.|:..:|.  :|.|.|:.   .|..:
Yeast   300 ----LQKTMRESFRHSARLSIAQRRP------------LSAESNNIG--DILLKHSNAVDMALLQ 346

  Fly   505 IHDFLFVASKIKSVSLYKRDDRCAYLYVHHNSDDFQIYFPSTERRQKFYDMILEMTADQVVFVNL 569
            ..|...::||:.:..:.|        ..|...:|              .|.|    ::|:..:::
Yeast   347 GLDQTRLSSKLDTTKIPK--------LAHKRPED--------------NDAI----SNQLELLSV 385

  Fly   570 SNDDANIEYEYDYDEQNRKMV-----------------LGKGTYGTVYAARDKQTQVRIAIKEV- 616
            .:.:   |.::|:..::..:|                 :|.|::|:||...:..|...:|:|:|
Yeast   386 ESGE---EEDHDFFGEDSDIVSLPTKIATPKNWLKGACIGSGSFGSVYLGMNAHTGELMAVKQVE 447

  Fly   617 ------------------PEKNSQD-------------------------VQPLHEEIKLHSQLR 638
                              .|.|.|:                         |..|..|:.|..:|.
Yeast   448 IKNNNIGVPTDNNKQANSDENNEQEEQQEKIEDVGAVSHPKTNQNIHRKMVDALQHEMNLLKELH 512

  Fly   639 HRNIVRYLGSCSENGFFKIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQD 703
            |.|||.|.|:..|.|...||:|.|||||:|.:| ..:||.:  ||.:..:::|||.|:.|||:::
Yeast   513 HENIVTYYGASQEGGNLNIFLEYVPGGSVSSML-NNYGPFE--ESLITNFTRQILIGVAYLHKKN 574

  Fly   704 IVHRDIKGDNVLVNTYSGVVKISDFGTSKRLARINPMTE---TFTGTLQYMAPEVIDQGVRGYGP 765
            |:||||||.|:|:: ..|.|||:|||.||:|:.:|....   :..|::.:|:|||:.|  .....
Yeast   575 IIHRDIKGANILID-IKGCVKITDFGISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQ--TATTA 636

  Fly   766 AADIWSFGCTNVEMATGKPPFIELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAISVMD 830
            .|||||.||..:||.|||.||.:. |...|:||:| ....|.||...::..|||:.:.|.:....
Yeast   637 KADIWSTGCVVIEMFTGKHPFPDF-SQMQAIFKIG-TNTTPEIPSWATSEGKNFLRKAFELDYQY 699

  Fly   831 RPSASQLLEDPFL 843
            ||||.:||:.|:|
Yeast   700 RPSALELLQHPWL 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ask1	NP_477089.3	DRHyd-ASK	24..59	CDD:466459
		MAP3K_TRAF_bd	74..445	CDD:463827	73/391 (19%)
		ASK_PH	457..560	CDD:465956	18/105 (17%)
		STKc_ASK	576..843	CDD:270794	108/330 (33%)
		HisK-N-like	948..1079	CDD:466452
STE11	NP_013466.1	SAM_Ste11_fungal	20..82	CDD:188933	13/70 (19%)
		Ras_bdg_2	121..224	CDD:434263	32/149 (21%)
		Protein Kinases, catalytic domain	415..712	CDD:473864	105/304 (35%)