DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ask1 and Map3k6

DIOPT Version :9

Sequence 1:	NP_477089.3	Gene:	Ask1 / 42366	FlyBaseID:	FBgn0014006	Length:	1363	Species:	Drosophila melanogaster
Sequence 2:	NP_057902.5	Gene:	Map3k6 / 53608	MGIID:	1855691	Length:	1291	Species:	Mus musculus

Alignment Length:	1302	Identity:	481/1302 - (36%)
Similarity:	688/1302 - (52%)	Gaps:	153/1302 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 FERLDFGETNVLETFYNADVAIIDLSILTQQRPLSYHYGVRESFGMKENILTYNDIDSKQTLSLK 105
            |..|..|:|..|::||||||.::::|....|..|.||.||||||.|..|:|..:..:.....:|:
Mouse    97 FATLALGDTAALDSFYNADVVVLEVSSSLAQPSLFYHLGVRESFSMTNNVLLCSQAELPDLQALR 161

  Fly   106 -------LSC-ANYLFLSYKRNAE----TNSCHLTSQPNSGNNSKEPNAEGRVPTLQWRLKRKLQ 158
                   ..| .:|..:.|...|.    .....|......|........|..:..|..||.|.|:
Mouse   162 EDVFQKNSDCVGSYTLIPYVVTATGRVLCGDAGLLRGIADGLVQAGAGTEALLTPLVGRLVRLLE 226

  Fly   159 DVEIQSKAHMREKFLSDMRTARDTYATNGAKLQSILHEMRKRLDDPHVLSGEVVHSFMCSLRDVQ 223
            .....|..:.||....|:|.||:.:  :|.:|:..|..:::|||...:||.::|.:.:.|.||||
Mouse   227 ATPTDSCGYFRETIRQDIRQARERF--SGQQLRQELARLQRRLDSVELLSPDIVMNLLLSYRDVQ 289

  Fly   224 DYDAMVRLVNDLKNIPNTRKYVETGNMSFLYAFALNRRNRKGDREKALESSLKALEKKENHFPDM 288
            ||.|::.||..|:.:| |....|..|:.|.|.||||||||.|||||||...|..::.:....||:
Mouse   290 DYSAIIELVETLQALP-TCDVAEQHNVCFHYTFALNRRNRPGDREKALAVLLPLVKYEGPVAPDL 353

  Fly   289 LCLCGRIYKDIFVESDYTDATSLAHAIKWYRQSFEVQPNEYAGINLATLLVIEGKEFTNTEELQH 353
            .|:|||||||:|..|.:.:|..|..|..|||::|:|:|:.::|||.|.||:..|:.|.::|||:.
Mouse   354 YCMCGRIYKDMFFTSGFQNAGHLEQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSEELRL 418

  Fly   354 IGMTLNNLIGKKGSLSSLSEYWDVATFFEISVLANDYAKAIQAAECMFKLKPPNWYLKSTIGNIS 418
            |||.|..|:.:||.:..:..||||..:....:||||..:.:.|||.::||..|.|||.|.:....
Mouse   419 IGMKLACLLARKGCVEKMQYYWDVGFYLGAQILANDPIQVVLAAEQLYKLNAPIWYLVSVMETFL 483

  Fly   419 LIHRFRKKPE-ERQPPIEEQVFQFWMDFFLEATNTEEV--KNSIRFPILILEPQKIYMPSYVTIN 480
            |...||..|| ...||:..   .||:.|.|::....::  ....:..:|:||..|:.:|:.:.|.
Mouse   484 LYQHFRPTPEPSGGPPLRA---HFWLHFLLQSCQPFKMAPPQEDQCLVLVLEINKVLLPARLEIQ 545

  Fly   481 MDADEKSIQIVNICLAHAKNACKKIHDFLFVASKIKSVSLYKRDDRCAYLYVHHNSDDFQIYFPS 545
               ....:..|.:.|...:.. :....:.|..:.|..:|..|.|.||.:||....:.|.|:.|||
Mouse   546 ---GTDPVSTVTLSLLDPETQ-EDPSSWTFPVTSICGISTSKLDQRCCFLYALPPAQDVQLCFPS 606

  Fly   546 TERRQKFYDMILEMTADQVVFVN----LSNDDAN-----IEYEYDYDEQNRKMVLGKGTYGTVYA 601
            .||.|:|..:|      ||:.:|    ...::|.     :|::|:|.|...::|||:||||.|||
Mouse   607 VERCQRFCGLI------QVLVMNPDSSAPTEEAEGAREVLEFDYEYSETGERLVLGRGTYGVVYA 665

  Fly   602 ARDKQTQVRIAIKEVPEKNSQDVQPLHEEIKLHSQLRHRNIVRYLGSCSENGFFKIFMEQVPGGS 666
            .||:.|:|||||||:||::|:..|||||||.||.:|||:||||||||.|:.|:.|||||:|||||
Mouse   666 GRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHKRLRHKNIVRYLGSASQGGYLKIFMEEVPGGS 730

  Fly   667 LSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTS 731
            ||.||.:.||||||||||::||::|||:||.||||..||||||||||||:||:||::||||||||
Mouse   731 LSSLLRSVWGPLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTS 795

  Fly   732 KRLARINPMTETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGKPPFIELGSAHAAM 796
            ||||.|.|.||||||||||||||:||||.||||.||||||.|||.:|||||:|||.||||..|||
Mouse   796 KRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAM 860

  Fly   797 FKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLEDPFLQDKPRKVRPALPINTEFG 861
            |:||.||.||.:|..|||.|:.|:||.|......|.||.:||.|||||...|...|..|.:|.
Mouse   861 FQVGMYKVHPPVPGSLSAEAQAFLLRTFEPDPRLRASAQELLGDPFLQPGKRSRSPGSPRHTP-- 923

  Fly   862 RSISVP-------ADRFVHKTTPPLSYNTTCNTPTTPE--LDITHSSSVDIDELPSNQFMLERRN 917
            |....|       ||......|.|.....:.:.|:.|:  |....:|.:.:.|.|:.:
Mouse   924 RPSGAPSGPSSPSADSATQSQTFPRPQAPSQHPPSPPKRCLSYGDTSQLRVPEEPAAE------- 981

  Fly   918 SHGFLLSPEIEPSTPSLRTSISETSETDGFYRLKKDSQRRTTLSKVLALDESKICDIWLKKVDAD 982
                      ||::|         .|:.|...|.::|:||..|:.||   |.::..:....::.:
Mouse   982 ----------EPASP---------EESSGLSLLHQESKRRAMLAAVL---EQEVPTLAENLLEQE 1024

  Fly   983 QNSIAIRKSDLEVLIRGLRDYIMNENEKHLEATINELKQKLNNDAVALDHLHLALYSFQDAVVCV 1047
            |:| .:.|..:|:|:|.|...|...|.:.|...:..|:.:|...::....|...|::|.|||..:
Mouse  1025 QDS-RLSKIHVELLLRCLGAQIHTPNRRQLAQELRTLQAQLRAQSLGPALLKGPLFAFPDAVKQI 1088

  Fly  1048 LRYHCIKPHWMFALDNLVKRAVQAAVTIFSPELGANLADKDLSGNDDESLRTSLMQKGSTESQEK 1112
            ||...|:|||||.||:|:.|||:||:.:    |.|....|.:....:||.:....||    .||.
Mouse  1089 LRRRQIRPHWMFVLDSLLSRAVRAAMAV----LDAESEKKAVLPRSEESSKEESQQK----PQES 1145

  Fly  1113 QSLEKVLPTSNTREGVGLTPAESGGDALSSSMECARI----LRDIRDNQQKLQRQLLEQQRQSMR 1173
            |:|:..|            |.|.|..:|...:...|.    |||:...:::..:.|::|
Mouse  1146 QALQSQL------------PPEQGPPSLMVELGLLRAETDRLRDLLAEKERECQALVQQ------ 1192

  Fly  1174 ALHNISQELAHIYMGGRKRLRRTINGFNKKCHRMSTSVGGTSGVRPNIAGNPRRQLNKHHFGLHE 1238
            |||.:..|.                       |.......|....|.
Mouse  1193 ALHRVHAET-----------------------RKYAPASETPATLPK------------------ 1216

  Fly  1239 VDEQLEQWLTQQEIDEFSKTLILNEGFTFDDFIYNMEKLDLMRLGLRVGIEVRLWKLIIQERVCT 1303
             |:.|.:||.:..:|..:...:|:..||....:....:.||:...:|.|:..|:|:.|:.:|...
Mouse  1217 -DQNLVRWLQELSVDPATIQTLLSHSFTLQTLLTCATQDDLVYTRIRGGMVCRIWRAILAQRAGA 1280

  Fly  1304 SS 1305
            :|
Mouse  1281 TS 1282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ask1	NP_477089.3	DUF4071	74..444	CDD:290020	140/382 (37%)
		STKc_ASK	576..843	CDD:270794	183/266 (69%)
		S_TKc	590..843	CDD:214567	179/252 (71%)
Map3k6	NP_057902.5	DUF4071	130..507	CDD:290020	140/382 (37%)
		STKc_ASK	640..907	CDD:270794	183/266 (69%)
		S_TKc	654..907	CDD:214567	179/252 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	901..997		29/123 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1125..1160		12/50 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848162
Domainoid	1	1.000	384	1.000	Domainoid score	I815
eggNOG	1	0.900	-	-		E1_KOG4279
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001687
OrthoInspector	1	1.000	-	-		otm42450
orthoMCL	1	0.900	-	-		OOG6_104013
Panther	1	1.100	-	-	O	PTHR11584
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1591
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.700