Protein Alignment Ask1 and Map3k6

DIOPT Version :10

• Sequence 1: NP_477089.3
• Gene: Ask1 / 42366
• FlyBaseID: FBgn0014006
• Length: 1363
• Species: Drosophila melanogaster
• Sequence 2: NP_057902.5
• Gene: Map3k6 / 53608
• MGIID: 1855691
• Length: 1291
• Species: Mus musculus
• Alignment Length: 1302
• Identity: 481/1302 - (36%)
• Similarity: 688/1302 - (52%)
• Gaps: 153/1302 - (11%)

  Fly    41 FERLDFGETNVLETFYNADVAIIDLSILTQQRPLSYHYGVRESFGMKENILTYNDIDSKQTLSLK 105
            |..|..|:|..|::||||||.::::|....|..|.||.||||||.|..|:|..:..:.....:|:
Mouse    97 FATLALGDTAALDSFYNADVVVLEVSSSLAQPSLFYHLGVRESFSMTNNVLLCSQAELPDLQALR 161

  Fly   106 -------LSC-ANYLFLSYKRNAE----TNSCHLTSQPNSGNNSKEPNAEGRVPTLQWRLKRKLQ 158
                   ..| .:|..:.|...|.    .....|......|........|..:..|..||.|.|:
Mouse   162 EDVFQKNSDCVGSYTLIPYVVTATGRVLCGDAGLLRGIADGLVQAGAGTEALLTPLVGRLVRLLE 226

  Fly   159 DVEIQSKAHMREKFLSDMRTARDTYATNGAKLQSILHEMRKRLDDPHVLSGEVVHSFMCSLRDVQ 223
            .....|..:.||....|:|.||:.:  :|.:|:..|..:::|||...:||.::|.:.:.|.||||
Mouse   227 ATPTDSCGYFRETIRQDIRQARERF--SGQQLRQELARLQRRLDSVELLSPDIVMNLLLSYRDVQ 289

  Fly   224 DYDAMVRLVNDLKNIPNTRKYVETGNMSFLYAFALNRRNRKGDREKALESSLKALEKKENHFPDM 288
            ||.|::.||..|:.:| |....|..|:.|.|.||||||||.|||||||...|..::.:....||:
Mouse   290 DYSAIIELVETLQALP-TCDVAEQHNVCFHYTFALNRRNRPGDREKALAVLLPLVKYEGPVAPDL 353

  Fly   289 LCLCGRIYKDIFVESDYTDATSLAHAIKWYRQSFEVQPNEYAGINLATLLVIEGKEFTNTEELQH 353
            .|:|||||||:|..|.:.:|..|..|..|||::|:|:|:.::|||.|.||:..|:.|.::|||:.
Mouse   354 YCMCGRIYKDMFFTSGFQNAGHLEQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQHFEDSEELRL 418

  Fly   354 IGMTLNNLIGKKGSLSSLSEYWDVATFFEISVLANDYAKAIQAAECMFKLKPPNWYLKSTIGNIS 418
            |||.|..|:.:||.:..:..||||..:....:||||..:.:.|||.::||..|.|||.|.:....
Mouse   419 IGMKLACLLARKGCVEKMQYYWDVGFYLGAQILANDPIQVVLAAEQLYKLNAPIWYLVSVMETFL 483

  Fly   419 LIHRFRKKPE-ERQPPIEEQVFQFWMDFFLEATNTEEV--KNSIRFPILILEPQKIYMPSYVTIN 480
            |...||..|| ...||:..   .||:.|.|::....::  ....:..:|:||..|:.:|:.:.|.
Mouse   484 LYQHFRPTPEPSGGPPLRA---HFWLHFLLQSCQPFKMAPPQEDQCLVLVLEINKVLLPARLEIQ 545

  Fly   481 MDADEKSIQIVNICLAHAKNACKKIHDFLFVASKIKSVSLYKRDDRCAYLYVHHNSDDFQIYFPS 545
               ....:..|.:.|...:.. :....:.|..:.|..:|..|.|.||.:||....:.|.|:.|||
Mouse   546 ---GTDPVSTVTLSLLDPETQ-EDPSSWTFPVTSICGISTSKLDQRCCFLYALPPAQDVQLCFPS 606

  Fly   546 TERRQKFYDMILEMTADQVVFVN----LSNDDAN-----IEYEYDYDEQNRKMVLGKGTYGTVYA 601
            .||.|:|..:|      ||:.:|    ...::|.     :|::|:|.|...::|||:||||.|||
Mouse   607 VERCQRFCGLI------QVLVMNPDSSAPTEEAEGAREVLEFDYEYSETGERLVLGRGTYGVVYA 665

  Fly   602 ARDKQTQVRIAIKEVPEKNSQDVQPLHEEIKLHSQLRHRNIVRYLGSCSENGFFKIFMEQVPGGS 666
            .||:.|:|||||||:||::|:..|||||||.||.:|||:||||||||.|:.|:.|||||:|||||
Mouse   666 GRDRHTRVRIAIKEIPERDSRFSQPLHEEIALHKRLRHKNIVRYLGSASQGGYLKIFMEEVPGGS 730

  Fly   667 LSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTS 731
            ||.||.:.||||||||||::||::|||:||.||||..||||||||||||:||:||::||||||||
Mouse   731 LSSLLRSVWGPLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLKISDFGTS 795

  Fly   732 KRLARINPMTETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGKPPFIELGSAHAAM 796
            ||||.|.|.||||||||||||||:||||.||||.||||||.|||.:|||||:|||.||||..|||
Mouse   796 KRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRPPFHELGSPQAAM 860

  Fly   797 FKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLEDPFLQDKPRKVRPALPINTEFG 861
            |:||.||.||.:|..|||.|:.|:||.|......|.||.:||.|||||...|...|..|.:|.
Mouse   861 FQVGMYKVHPPVPGSLSAEAQAFLLRTFEPDPRLRASAQELLGDPFLQPGKRSRSPGSPRHTP-- 923

  Fly   862 RSISVP-------ADRFVHKTTPPLSYNTTCNTPTTPE--LDITHSSSVDIDELPSNQFMLERRN 917
            |....|       ||......|.|.....:.:.|:.|:  |....:|.:.:.|.|:.:
Mouse   924 RPSGAPSGPSSPSADSATQSQTFPRPQAPSQHPPSPPKRCLSYGDTSQLRVPEEPAAE------- 981

  Fly   918 SHGFLLSPEIEPSTPSLRTSISETSETDGFYRLKKDSQRRTTLSKVLALDESKICDIWLKKVDAD 982
                      ||::|         .|:.|...|.::|:||..|:.||   |.::..:....::.:
Mouse   982 ----------EPASP---------EESSGLSLLHQESKRRAMLAAVL---EQEVPTLAENLLEQE 1024

  Fly   983 QNSIAIRKSDLEVLIRGLRDYIMNENEKHLEATINELKQKLNNDAVALDHLHLALYSFQDAVVCV 1047
            |:| .:.|..:|:|:|.|...|...|.:.|...:..|:.:|...::....|...|::|.|||..:
Mouse  1025 QDS-RLSKIHVELLLRCLGAQIHTPNRRQLAQELRTLQAQLRAQSLGPALLKGPLFAFPDAVKQI 1088

  Fly  1048 LRYHCIKPHWMFALDNLVKRAVQAAVTIFSPELGANLADKDLSGNDDESLRTSLMQKGSTESQEK 1112
            ||...|:|||||.||:|:.|||:||:.:    |.|....|.:....:||.:....||    .||.
Mouse  1089 LRRRQIRPHWMFVLDSLLSRAVRAAMAV----LDAESEKKAVLPRSEESSKEESQQK----PQES 1145

  Fly  1113 QSLEKVLPTSNTREGVGLTPAESGGDALSSSMECARI----LRDIRDNQQKLQRQLLEQQRQSMR 1173
            |:|:..|            |.|.|..:|...:...|.    |||:...:::..:.|::|
Mouse  1146 QALQSQL------------PPEQGPPSLMVELGLLRAETDRLRDLLAEKERECQALVQQ------ 1192

  Fly  1174 ALHNISQELAHIYMGGRKRLRRTINGFNKKCHRMSTSVGGTSGVRPNIAGNPRRQLNKHHFGLHE 1238
            |||.:..|.                       |.......|....|.
Mouse  1193 ALHRVHAET-----------------------RKYAPASETPATLPK------------------ 1216

  Fly  1239 VDEQLEQWLTQQEIDEFSKTLILNEGFTFDDFIYNMEKLDLMRLGLRVGIEVRLWKLIIQERVCT 1303
             |:.|.:||.:..:|..:...:|:..||....:....:.||:...:|.|:..|:|:.|:.:|...
Mouse  1217 -DQNLVRWLQELSVDPATIQTLLSHSFTLQTLLTCATQDDLVYTRIRGGMVCRIWRAILAQRAGA 1280

  Fly  1304 SS 1305
            :|
Mouse  1281 TS 1282

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ask1	NP_477089.3	DRHyd-ASK	24..59	CDD:466459	8/17 (47%)
		MAP3K_TRAF_bd	74..445	CDD:463827	140/383 (37%)
		ASK_PH	457..560	CDD:465956	27/102 (26%)
		STKc_ASK	576..843	CDD:270794	183/266 (69%)
		HisK-N-like	948..1079	CDD:466452	42/130 (32%)
Map3k6	NP_057902.5	MAP3K_TRAF_bd	130..508	CDD:463827	140/383 (37%)
		ASK_PH	524..618	CDD:465956	27/103 (26%)
		STKc_ASK	640..907	CDD:270794	183/266 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	901..997		29/123 (24%)
		HisK-N-like	993..1117	CDD:466452	42/131 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1125..1160		12/50 (24%)