Protein Alignment Ask1 and Map3k15

DIOPT Version :10

• Sequence 1: NP_477089.3
• Gene: Ask1 / 42366
• FlyBaseID: FBgn0014006
• Length: 1363
• Species: Drosophila melanogaster
• Sequence 2: XP_038956496.1
• Gene: Map3k15 / 501558
• RGDID: 1560603
• Length: 1327
• Species: Rattus norvegicus
• Alignment Length: 1331
• Identity: 576/1331 - (43%)
• Similarity: 786/1331 - (59%)
• Gaps: 145/1331 - (10%)

  Fly    21 ALEEIKQAVQSAGANFQRVQFERLDFGETNVLETFYNADVAIIDLSILTQQRPLSYHYGVRESFG 85
            ||:.:.:|.::.||:...|.|..||||||.||:.||:|||||:|:|.:::|..|.||.||||||.
  Rat    83 ALKCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDADVAIVDMSDISRQPSLFYHLGVRESFD 147

  Fly    86 MKENILTYNDIDSKQTLSLK--------LSCANYLFLSYKRN--AETNSCHLTSQPNSGNNSKEP 140
            |..|::.|.|.|:...||||        .|..||.|:.|...  |:...|...:| ...:...:|
  Rat   148 MANNVILYYDTDADTALSLKDMVTQKNIASSGNYYFIPYTVTPCADYFCCESDAQ-RRASEYMQP 211

  Fly   141 NAEGRVPTLQW-------------RLKRKLQDVEIQSKAHMREKFLSDMRTARDTYATNGAKLQS 192
            |         |             |....|:|:.:.|.|:.:|..|:|:|.||:.|  .|.:|..
  Rat   212 N---------WDTILGPLCMPLVDRFTTLLKDIRVTSCAYYKETLLNDIRKAREKY--QGDELAK 265

  Fly   193 ILHEMRKRLDDPHVLSGEVVHSFMCSLRDVQDYDAMVRLVNDLKNIPNTRKYVETGNMSFLYAFA 257
            .|..::.|:|:..||:.:::.:.:.|.||:|||||||:||..||.:| |....:..|:.|.||||
  Rat   266 ELTRIKFRMDNIEVLTSDIIINLLLSYRDIQDYDAMVKLVETLKMLP-TCDLADQHNIKFHYAFA 329

  Fly   258 LNRRNRKGDREKALESSLKALEKKENHFPDMLCLCGRIYKDIFVESDYTDATSLAHAIKWYRQSF 322
            |||||..|||||||:..|:.|...::..|||.|||||||||||::|...:..|...||:|||:.|
  Rat   330 LNRRNSTGDREKALQVMLQVLRSCDHPAPDMFCLCGRIYKDIFLDSGCEEDASRDSAIEWYRKGF 394

  Fly   323 EVQPNEYAGINLATLLVIEGKEFTNTEELQHIGMTLNNLIGKKGSLSSLSEYWDVATFFEISVLA 387
            |:|.:.|:|||||.||::.|::|..:.||:.||:.||:|:|:||||..::.||||..||.:|:||
  Rat   395 ELQSSLYSGINLAVLLIVSGQQFETSMELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFTVSMLA 459

  Fly   388 NDYAKAIQAAECMFKLKPPNWYLKSTIGNISLIHRFRKKPEERQPPIEEQVFQFWMDFFLEATNT 452
            :|..||:||||.:||||||.|||:|.:.|:.||.|| |||.....|.:|:: .||:|...||||
  Rat   460 SDIGKAVQAAERLFKLKPPVWYLRSLVQNLLLIQRF-KKPITEHSPRQERL-NFWLDIIFEATN- 521

  Fly   453 EEVKNSIRFPILILEPQKIYMPSYVTINMDADEKSIQIVNICLAHAKNACKKIHDFLFVASKIKS 517
             ||.|.:|||:|::||.|||.|:||:||.:|:|:::.:.::    :....|:||::.|.||.||.
  Rat   522 -EVTNGLRFPVLVIEPTKIYQPAYVSINNEAEERTVSLWHV----SPTEMKQIHEWNFTASSIKG 581

  Fly   518 VSLYKRDDRCAYLYVHHNSDDFQIYFPSTERRQKFYDMILEMTADQV---VFVNLSNDDANIEYE 579
            :||.|.|:||.:||||.|||||||||.:.|:..:|..::.||..:.|   |.:....|...:|||
  Rat   582 ISLSKFDERCCFLYVHDNSDDFQIYFSTEEQCNRFCSLVKEMLNNGVGSTVELEGEADGDTLEYE 646

  Fly   580 YDYDEQNRKMVLGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQDVQPLHEEIKLHSQLRHRNIVR 644
            ||:|....::|||||:||.|||.||...||||||||:||::.:..|||||||.||..|:|||||:
  Rat   647 YDHDVNGERVVLGKGSYGVVYAGRDLSNQVRIAIKEIPERDIRYSQPLHEEIALHKYLKHRNIVQ 711

  Fly   645 YLGSCSENGFFKIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDI 709
            ||||.||||:.|||||||||||||.||.:||||:|  |.|:.||:||||||||||||..||||||
  Rat   712 YLGSVSENGYIKIFMEQVPGGSLSALLRSKWGPMK--EPTIKFYTKQILEGLKYLHENQIVHRDI 774

  Fly   710 KGDNVLVNTYSGVVKISDFGTSKRLARINPMTETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGC 774
            ||||||||||||||||||||||||||.|||.||||||||||||||:||||.||||..|||||.||
  Rat   775 KGDNVLVNTYSGVVKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGC 839

  Fly   775 TNVEMATGKPPFIELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLE 839
            |.:||||.:|||.|||...|||||||.:|.||.|||.|||.|:.|||.||......|.:|:.||:
  Rat   840 TIIEMATSRPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPQKRVTAADLLQ 904

  Fly   840 DPFLQ--DKPRKVRPALPINTEFGRSISVPADRFVHKTTPPLSYNT-TCNTPTTPELDITHSS-- 899
            :.||:  :|.:|                   :|...|.:..:...| |...|::.||..:.||
  Rat   905 EGFLRQVNKGKK-------------------NRIAFKPSEGVRSGTGTLALPSSGELMGSSSSEH 950

  Fly   900 ---SVDIDELPSNQF----MLERRNSHGFLLSPEIEPSTPSLRTSISETSETD-GFYRLKKDSQR 956
               |.|.|..|...|    :.:.:.||  |||...|.|....|::.....|.| |.:.|:|||:|
  Rat   951 GSISPDSDAQPDAFFEKVQVPKPQLSH--LLSVPDESSALDDRSTALPPEERDPGLFLLRKDSER 1013

  Fly   957 RTTLSKVLALDESKICDIWLKKVDADQNSIAIRKSDLEVLIRGLRDYIMNENEKHLEATINELKQ 1021
            |..|.::|..:::::.....:.|......:.:....::.:|..|||:|.:...:.:.|||::||.
  Rat  1014 RAILYRILWEEQNQVASNLQECVVQSSEELLLSVGHIKQIIGILRDFIRSPEHRVMAATISKLKV 1078

  Fly  1022 KLNNDAVALDHLHLALYSFQDAVVCVLRYHCIKPHWMFALDNLVKRAVQAAVTIFSPELGANL-- 1084
            .|:.|:.:::.:||.|:.|||||..:||.|.|:||||||:||:::|||||||.|..|||.|:.
  Rat  1079 DLDFDSSSINQIHLILFGFQDAVNRILRNHLIRPHWMFAMDNIIRRAVQAAVAILIPELQAHFEP 1143

  Fly  1085 ------ADKDLSGNDDESLRTSLMQKGSTESQEKQSLEKVLPTSNTREGVGLTPAESGGDALSSS 1143
                  .|||.....|..|...|.|            |..:.|..||.| .:...|........|
  Rat  1144 ASETEGVDKDTEMERDYPLVDLLSQ------------EVHVTTRGTRHG-SVAIQEGQPHQQDPS 1195

  Fly  1144 MECARILRDIRDNQQKLQRQLLEQQRQSMRALHNI----SQELAHIYMGGRKRLRRTINGFNKKC 1204
            ::    |..:|....:|...|::::|:....|..|    :|||.|:.:             ..||
  Rat  1196 LQ----LSKLRQETNRLWEHLVQKEREYQNLLRLILEQKTQELYHLQL-------------QYKC 1243

  Fly  1205 HRMSTSVGGTSGVRPNIAGNPRRQLNKHHFGLHEVDEQLEQWLTQQEIDEFSKTLILNEGFTFDD 1269
            :      |||....|             |.|| ..:.:|..||..|.:|..:...|:.|.:|..|
  Rat  1244 N------GGTENPPP-------------HDGL-GTNRELIDWLQLQGVDANTIEKIVEEDYTLSD 1288

  Fly  1270 FIYNMEKLDLMRLGLRVGIEVRLWKLIIQER 1300
            .:.::.|.||..|.||.|:..|||..:.|.|
  Rat  1289 ILNDITKEDLRCLRLRGGVLCRLWHAVSQHR 1319

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ask1	NP_477089.3	DRHyd-ASK	24..59	CDD:466459	15/34 (44%)
		MAP3K_TRAF_bd	74..445	CDD:463827	168/393 (43%)
		ASK_PH	457..560	CDD:465956	47/102 (46%)
		STKc_ASK	576..843	CDD:270794	188/266 (71%)
		HisK-N-like	948..1079	CDD:466452	49/130 (38%)
Map3k15	XP_038956496.1	DRHyd-ASK	86..121	CDD:466459	15/34 (44%)
		MAP3K_TRAF_bd	136..514	CDD:463827	168/392 (43%)
		ASK_PH	525..624	CDD:465956	47/102 (46%)
		STKc_ASK	643..908	CDD:270794	188/266 (71%)
		HisK-N-like	1005..1136	CDD:466452	49/130 (38%)