Protein Alignment Ask1 and Map3k5

DIOPT Version :10

• Sequence 1: NP_477089.3
• Gene: Ask1 / 42366
• FlyBaseID: FBgn0014006
• Length: 1363
• Species: Drosophila melanogaster
• Sequence 2: NP_001264623.1
• Gene: Map3k5 / 365057
• RGDID: 1306565
• Length: 1381
• Species: Rattus norvegicus
• Alignment Length: 1347
• Identity: 559/1347 - (41%)
• Similarity: 782/1347 - (58%)
• Gaps: 155/1347 - (11%)

  Fly    21 ALEEIKQAVQSAGANFQRVQFERLDFGETNVLETFYNADVAIIDLSILTQQRPLSYHYGVRESFG 85
            ||:.:::|.::.||..:.:.|.:||||||.||:.|||||:|::::|...:|..|.||.||||||.
  Rat   119 ALQSLREACEAVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFS 183

  Fly    86 MKENILTYNDIDSKQTLSLK-LSC-------ANYLFLSYKRNAETN-SCHLTSQPNSGNNSKEPN 141
            |..||:.|.|.:|....||| :.|       .||.|:.|....... .|..:|.........:||
  Rat   184 MANNIILYCDTNSDSLQSLKEIICQKNTVCTGNYTFIPYMVTPHNKVYCCDSSFMKGLTELMQPN 248

  Fly   142 AE---GRV--PTLQWRLKRKLQDVEIQSKAHMREKFLSDMRTARDTYATNGAKLQSILHEMRKRL 201
            .|   |.:  |.:. |..:.|:..:..|..:.||..|:|:|.||:.|  .|.:|.:.|..:|:|:
  Rat   249 FELLLGPICLPLVD-RFVQLLKVAQASSSQYFRESILNDIRKARNLY--TGKELAAELARIRQRV 310

  Fly   202 DDPHVLSGEVVHSFMCSLRDVQDYDAMVRLVNDLKNIPNTRKYVETGNMSFLYAFALNRRNRKGD 266
            |:..||:.::|.:.:.|.||:||||::|:||..|:.:| |.......::.|.|||||||||..||
  Rat   311 DNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLP-TFDLASHHHVKFHYAFALNRRNLPGD 374

  Fly   267 REKALESSLKALEKKENHFPDMLCLCGRIYKDIFVESDYTDATSLAHAIKWYRQSFEVQPNEYAG 331
            |.|||:..:..::.:|....||.||.||||||:|::|::||..|..|...|::::||.:|...:|
  Rat   375 RAKALDIMIPMVQSEEQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSG 439

  Fly   332 INLATLLVIEGKEFTNTEELQHIGMTLNNLIGKKGSLSSLSEYWDVATFFEISVLANDYAKAIQA 396
            ||.|.||:..|.:|.::.||:.:|:.|::|:||||:|..|..||:|..|...||||||:.:.|||
  Rat   440 INYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHLRVIQA 504

  Fly   397 AECMFKLKPPNWYLKSTIGNISLIHRFRKKPEERQPPIEEQVFQFWMDFFLEATNTEEVKNSIRF 461
            :|.:|:||.|.|||||.:..|.:...|.|...| ||..::::..|||||.:|||.|:  ...:||
  Rat   505 SEKLFRLKTPAWYLKSIVETILIYKHFVKLTTE-QPTAKQELVDFWMDFLVEATKTD--VTVVRF 566

  Fly   462 PILILEPQKIYMPSYVTINMDADEKSIQIVNICLAHAKNACKKIHDFLFVASKIKSVSLYKRDDR 526
            |:|||||.|||.|||::||.:.:||:|.|.:: |...|   |.||::.|.||.::.||:.|.::|
  Rat   567 PVLILEPTKIYQPSYLSINNEVEEKTISIWHV-LPDDK---KGIHEWNFNASSVRGVSISKFEER 627

  Fly   527 CAYLYVHHNSDDFQIYFPSTERRQKFYDMILEMTADQVVFVNLSN-DDANIEYEYDYDEQNRKMV 590
            |.:|||.||||||||||.:....::|::|:..:|.::.......: :..::||:|::||...::|
  Rat   628 CCFLYVLHNSDDFQIYFCTELHCKRFFEMVNTITEEKGRGAEEGDCEGDSLEYDYEHDENGDRVV 692

  Fly   591 LGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQDVQPLHEEIKLHSQLRHRNIVRYLGSCSENGFF 655
            |||||||.|||.||...||||||||:||::|:..|||||||.||..|:|:|||:||||.|||||.
  Rat   693 LGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSFSENGFI 757

  Fly   656 KIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYS 720
            |||||||||||||.||.:|||||||||.|:.||:|||||||||||:..||||||||||||:||||
  Rat   758 KIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYS 822

  Fly   721 GVVKISDFGTSKRLARINPMTETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGKPP 785
            ||:||||||||||||.|||.||||||||||||||:||:|.||||.||||||.|||.:||||||||
  Rat   823 GVLKISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPP 887

  Fly   786 FIELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLEDPFLQ--DKPR 848
            |.|||...|||||||.:|.||.|||.:||.||.|||:||......|..|:.||.|.||:  .|.:
  Rat   888 FYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKK 952

  Fly   849 KVRPALP----INTEFGRSISVPADRFVHKTTPPLSYNTTCNTPTTPELDITHSSSVDIDELPSN 909
            |.:|.|.    ...|:.||||:|....|..|:....|.:.  :|.|              ||.::
  Rat   953 KTQPKLSGMWLHGEEYLRSISLPVPVLVEDTSSSSEYGSV--SPDT--------------ELKAD 1001

  Fly   910 QFMLE-RRNSHG----------FLLSPE------IEPSTPSLRTSISETSETDGFYRLKKDSQRR 957
            .|..: |..|.|          ||..|:      ..|.:|..:.|        ||:.|:|||:||
  Rat  1002 PFSFKTRAKSCGEKDGKGIRTLFLGIPDENFEDHSAPPSPEEKDS--------GFFMLRKDSERR 1058

  Fly   958 TTLSKVLALDESKICDIWLKKVDADQNSIAIRKSDLEVLIRGLRDYIMNENEKHLEATINELKQK 1022
            .||.::|..|:.|:....::.:........::...:..||..||:::.:.:.|.:..|::.||.:
  Rat  1059 ATLHRILTEDQDKVVRNLMESLAQGPEEPKLKWEHITTLISSLREFVRSTDRKIIATTLSRLKLE 1123

  Fly  1023 LNNDAVALDHLHLALYSFQDAVVCVLRYHCIKPHWMFALDNLVKRAVQAAVTIFSPEL------- 1080
            |:.|:..:..:.:.|:.|||||..|||.|.||||||||||:::::|||.|:||..|||
  Rat  1124 LDFDSHGISQVQVVLFGFQDAVNKVLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLA 1188

  Fly  1081 -GANLAD-KDLSGNDDESLRTSLMQKGSTESQEKQSLEKVLPTSNTREGVGLTPAESGGDALSSS 1143
             .::.|| :||..:|:..           ||...|:..:..|.:..      ..|.||...|||:
  Rat  1189 SESDTADPEDLDVDDEHE-----------ESPSNQTARRPQPVAED------AVATSGVSTLSST 1236

  Fly  1144 --------------------MECARILRDIRDNQQKLQRQLLEQQRQSMRALHNISQELAHIYMG 1188
                                ||..|:|.::...:::|| .||.|      |:....||:.|:.:
  Rat  1237 VSHDSQNAHRSLNVQLGRMKMETNRLLEELVRKEKELQ-ALLHQ------AIEEKDQEIKHLRL- 1293

  Fly  1189 GRKRLRRTINGFNKKCHRMSTSVGGTSGVRPNIAGNPRRQLNKHHFGLHEVDEQLEQWLTQQEID 1253
                          |...:.|            .|.|...||..  |....|.:|..||.:...|
  Rat  1294 --------------KSQPIDT------------PGFPVCHLNAP--GTAIEDSELTGWLRENGAD 1330

  Fly  1254 EFSKTLILNEGFTFDDFIYNMEKLDLMRLGLRVGIEVRLWKLIIQER 1300
            |.:.:..|.|.:|..|.:|.:.:.||..|.||.|:...|||.||..|
  Rat  1331 EDTISRFLAEDYTLVDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFR 1377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ask1	NP_477089.3	DRHyd-ASK	24..59	CDD:466459	15/34 (44%)
		MAP3K_TRAF_bd	74..445	CDD:463827	151/384 (39%)
		ASK_PH	457..560	CDD:465956	48/102 (47%)
		STKc_ASK	576..843	CDD:270794	192/266 (72%)
		HisK-N-like	948..1079	CDD:466452	47/130 (36%)
Map3k5	NP_001264623.1	DRHyd-ASK	122..157	CDD:466459	15/34 (44%)
		MAP3K_TRAF_bd	172..552	CDD:463827	151/384 (39%)
		ASK_PH	562..661	CDD:465956	48/102 (47%)
		STKc_ASK	678..945	CDD:270794	192/266 (72%)
		HisK-N-like	1049..1180	CDD:466452	47/130 (36%)