Protein Alignment Ask1 and byr2

DIOPT Version :10

• Sequence 1: NP_477089.3
• Gene: Ask1 / 42366
• FlyBaseID: FBgn0014006
• Length: 1363
• Species: Drosophila melanogaster
• Sequence 2: NP_595714.2
• Gene: byr2 / 2540612
• PomBaseID: SPBC1D7.05
• Length: 659
• Species: Schizosaccharomyces pombe
• Alignment Length: 707
• Identity: 185/707 - (26%)
• Similarity: 304/707 - (42%)
• Gaps: 159/707 - (22%)

  Fly   235 LKNIPNTRKYVETGNMSFLYAFALNRRNRKGDREKALESSLKA---LEKKE--NHFPDMLCL--- 291
            ||:| ...||:|..:.:.:....||.......::..:|::.|.   |::::  ..||....|
pombe    13 LKSI-GLEKYIEQFSQNNIEGRHLNHLTLPLLKDLGIENTAKGKQFLKQRDYLREFPRPCILRFI 76

  Fly   292 -CGRIYKDIFVESDYTDATSLAHAIKWY----RQSFEVQPNEYAGINLAT--------------- 336
             |....:.:....||  ..:||.|:|.:    ...|.|..::.:.|.|.|
pombe    77 ACNGQTRAVQSRGDY--QKTLAIALKKFSLEDASKFIVCVSQSSRIKLITEEEFKQICFNSSSPE 139

  Fly   337 --LLVIEGKE-----FTNTEELQHIGMTLNNLIGKKGSLS-SLSEYWDVATFFEISVLANDYAKA 393
              .|:|..||     |.:......|.:.....:..:.||| .||.....:| .:.||.:|: ||.
pombe   140 RDRLIIVPKEKPCPSFEDLRRSWEIELAQPAALSSQSSLSPKLSSVLPTST-QKRSVRSNN-AKP 202

  Fly   394 IQAAECMFKLKPPNWYLKSTIG---------------------NISL-------IHRF------- 423
            .::.:     :||:..:.|.|.                     |:|:       :..|
pombe   203 FESYQ-----RPPSELINSRISDFFPDHQPKLLEKTISNSLRRNLSIRTSQGHNLGNFGQEILPR 262

  Fly   424 ---RKKPEERQPPIEEQVFQFWMDFFLEATNTEEVKNSIRF------PILILEPQKIYMPSYVTI 479
               |.:|.|...|:..          |..:..|:|....|.      |:.:...|:|..|..:
pombe   263 SSRRARPSELVCPLSS----------LRISVAEDVNRLPRIDRGFDPPLTVSSTQRISRPPSL-- 315

  Fly   480 NMDADEKSIQIVNICLAHAKNACKKIHDFLFVASKIKSVSLYKRDDRCAYLYVHHNSDDFQIYFP 544
                 :|||.:|.:...:..|..:|       :||....|.....:.....:...:|..| |..|
pombe   316 -----QKSITMVGVEPLYQSNGNEK-------SSKYNVFSESAHGNHQVLSFSPGSSPSF-IEQP 367

  Fly   545 STERRQKFYDMILEMTADQVVFVNLSNDDANIEYEYDYDEQNRKMV----LGKGTYGTVYAARDK 605
            |                 .:...:.:::|.| ..|.|.|:|:.|.:    :|.|::|.||...:.
pombe   368 S-----------------PISPTSTTSEDTN-TLEEDTDDQSIKWIRGALIGSGSFGQVYLGMNA 414

  Fly   606 QTQVRIAIKEV--------PEKNSQDVQPLHEEIKLHSQLRHRNIVRYLGSCSENGFFKIFMEQV 662
            .:...:|:|:|        .:::::.:..|..||.|..:|.|.:||:||||...:....||:|.|
pombe   415 SSGELMAVKQVILDSVSESKDRHAKLLDALAGEIALLQELSHEHIVQYLGSNLNSDHLNIFLEYV 479

  Fly   663 PGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVKISD 727
            ||||::.|| |.:|..:  |:.:..:.||.|:||:|||.:.||||||||.|:||:. .|.:||||
pombe   480 PGGSVAGLL-TMYGSFE--ETLVKNFIKQTLKGLEYLHSRGIVHRDIKGANILVDN-KGKIKISD 540

  Fly   728 FGTSKRLARINPMTET------FTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGKPPF 786
            ||.||:|...:..|:|      |.|:..:|||||:.|.:  :....||||.||..:||.|.|.|:
pombe   541 FGISKKLELNSTSTKTGGARPSFQGSSFWMAPEVVKQTM--HTEKTDIWSLGCLVIEMLTSKHPY 603

  Fly   787 IELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLEDPFL 843
            ....... |:|::| ....|..|..:|::|.:|:.:.|||....||:||:||..||:
pombe   604 PNCDQMQ-AIFRIG-ENILPEFPSNISSSAIDFLEKTFAIDCNLRPTASELLSHPFV 658

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ask1	NP_477089.3	DRHyd-ASK	24..59	CDD:466459
		MAP3K_TRAF_bd	74..445	CDD:463827	54/283 (19%)
		ASK_PH	457..560	CDD:465956	19/108 (18%)
		STKc_ASK	576..843	CDD:270794	106/284 (37%)
		HisK-N-like	948..1079	CDD:466452
byr2	NP_595714.2	SAM_2	1..65	CDD:429573	11/52 (21%)
		Protein Kinases, catalytic domain	393..658	CDD:473864	102/272 (38%)