Protein Alignment Ask1 and map3k15

DIOPT Version :10

• Sequence 1: NP_477089.3
• Gene: Ask1 / 42366
• FlyBaseID: FBgn0014006
• Length: 1363
• Species: Drosophila melanogaster
• Sequence 2: XP_012812444.1
• Gene: map3k15 / 100216453
• XenbaseID: XB-GENE-1002755
• Length: 1333
• Species: Xenopus tropicalis
• Alignment Length: 1342
• Identity: 570/1342 - (42%)
• Similarity: 805/1342 - (59%)
• Gaps: 124/1342 - (9%)

  Fly     3 VVCVMD----TAVGDHLEDRQCALEEIKQAVQSAGANFQRVQFERLDFGETNVLETFYNADVAII 63
            ||.|::    :|:|...|..  ||..:::|.:..||:...|.|..||||||.||:|||:||||::
 Frog    62 VVYVLNDSPKSAMGGSPESG--ALHCLRRACEGEGAHLSSVNFGELDFGETAVLDTFYDADVAVV 124

  Fly    64 DLSILTQQRPLSYHYGVRESFGMKENILTYNDIDSKQTLSLK--------LSCANYLFLSY-KRN 119
            |:|.:.:|..|.||.||||||.|..|::.|:|.|...:||||        .|..||.|:|| ...
 Frog   125 DMSDVGRQPSLFYHLGVRESFDMANNVIIYHDTDPDTSLSLKDMVSQKNTASSGNYYFISYILTP 189

  Fly   120 AETNSCHLTSQPNSGNNSKEPNAEGRVPTLQWRLKRK----LQDVEIQSKAHMREKFLSDMRTAR 180
            .....|..|......:...:||.:..:..|...|..|    |:|:.:.|.|:.:|..|||:|.||
 Frog   190 CGDYFCCETDAQRRASEYMQPNWDNLLGPLCVPLVDKFISLLKDIHVTSCAYNKETLLSDIRKAR 254

  Fly   181 DTYATNGAKLQSILHEMRKRLDDPHVLSGEVVHSFMCSLRDVQDYDAMVRLVNDLKNIPNTRKYV 245
            :.|  .|.:|...|..::.|:|:..||:.::|.:.:.|.||:||||||||||..|:.:| |....
 Frog   255 EKY--QGDELAKELARLKLRMDNTEVLTPDIVINLLLSYRDIQDYDAMVRLVETLEMLP-TCDLA 316

  Fly   246 ETGNMSFLYAFALNRRNRKGDREKALESSLKALEKKENHFPDMLCLCGRIYKDIFVESDYTDATS 310
            :..|:.|.|||||||||..|||||||...|:.|:..::..|||.|||||||||:|::|||.|..|
 Frog   317 DQHNIKFHYAFALNRRNNTGDREKALHVMLQVLQACDHPAPDMFCLCGRIYKDMFLDSDYKDTKS 381

  Fly   311 LAHAIKWYRQSFEVQPNEYAGINLATLLVIEGKEFTNTEELQHIGMTLNNLIGKKGSLSSLSEYW 375
            ...||:|||:.||:||:.|:|||||.||::.|::|.::.||:.||:.||:|:|:||||..::.||
 Frog   382 RDSAIEWYRKGFELQPSLYSGINLAVLLIVAGQQFESSMELRKIGVRLNSLLGRKGSLEKMNNYW 446

  Fly   376 DVATFFEISVLANDYAKAIQAAECMFKLKPPNWYLKSTIGNISLIHRFRKKPEERQPPIEEQVFQ 440
            ||..||.:|:||.|..||:||:|.:||||||.|||:|.:.|:.||.||||...|..|  .::.|.
 Frog   447 DVGQFFIVSMLAGDIGKAVQASERLFKLKPPVWYLRSAVQNLLLIQRFRKLNTEHSP--RQERFN 509

  Fly   441 FWMDFFLEATNTEEVKNSIRFPILILEPQKIYMPSYVTINMDADEKSIQIVNICLAHAKNACKKI 505
            ||||..:||  |:|..|.:|||:|:|||.|:|.||||:||.:|||:::.:.::.....|.    |
 Frog   510 FWMDIIVEA--TKESTNGLRFPVLVLEPTKVYQPSYVSINKEADERTVSLWHVSPVEMKG----I 568

  Fly   506 HDFLFVASKIKSVSLYKRDDRCAYLYVHHNSDDFQIYFPSTERRQKFYDMILEMTADQV---VFV 567
            |::.|.||.|:.:|:.|.|:||.:||||.|||||||||.:.::..:|..::.|:..|.|   |.:
 Frog   569 HEWNFTASSIRGISISKFDERCCFLYVHDNSDDFQIYFSTEDQCNRFCTLVKEIITDVVGNTVEL 633

  Fly   568 NLSNDDANIEYEYDYDEQNRKMVLGKGTYGTVYAARDKQTQVRIAIKEVPEKNSQDVQPLHEEIK 632
            ....|...:||||||||...::|||:||||.|||.||...||||||||:|||:|:..|||||||.
 Frog   634 EGEADGDTLEYEYDYDENGDRVVLGRGTYGVVYAGRDLSNQVRIAIKEIPEKDSRYSQPLHEEIA 698

  Fly   633 LHSQLRHRNIVRYLGSCSENGFFKIFMEQVPGGSLSDLLETKWGPLKDNESTMAFYSKQILEGLK 697
            ||..|:|||||:||||.||:|:.|||||||||||||.||.:||||||  |.|:.||:||||||||
 Frog   699 LHKYLKHRNIVQYLGSISEDGYIKIFMEQVPGGSLSVLLRSKWGPLK--EPTIKFYTKQILEGLK 761

  Fly   698 YLHEQDIVHRDIKGDNVLVNTYSGVVKISDFGTSKRLARINPMTETFTGTLQYMAPEVIDQGVRG 762
            ||||..|||||||||||||||||||:||||||||||||.:||.||||||||||||||:||:|.||
 Frog   762 YLHENQIVHRDIKGDNVLVNTYSGVLKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDKGPRG 826

  Fly   763 YGPAADIWSFGCTNVEMATGKPPFIELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAIS 827
            ||..|||||.|||.:|||||:|||.|||...|||||||.:|.||.|||.|||.|:.|||.||...
 Frog   827 YGAPADIWSLGCTIIEMATGRPPFHELGEPQAAMFKVGMFKIHPEIPESLSAEARAFILLCFEPD 891

  Fly   828 VMDRPSASQLLEDPFLQ--DKPRKVRPALPINTEFGRSISVPADRFVHKTTPPL-----SYNTTC 885
            ...|.:.:.||.|.||:  :|.:|.:.|.. .:::.||.|:|.         |:     ..:::.
 Frog   892 PAKRATVTDLLRDFFLKQSNKGKKSKIAFK-PSDYNRSTSLPI---------PVPGELAGSSSSE 946

  Fly   886 NTPTTPELDITHSSSVDIDELPSNQFMLERRNSHGFLLSPEIEPSTPSLRTSISETSETD-GFYR 949
            :...:|:.|.......:..:..::.|.:.:.::..||..|: :.|....|::.....|.| |.:.
 Frog   947 HGSVSPDSDAKQELFFEKTKRSNSDFPINKGSNSNFLSVPD-DSSVSEDRSNPPSPEERDSGLFL 1010

  Fly   950 LKKDSQRRTTLSKVLALDESKICDIWLKKVDADQNSIAIRKSDLEVLIRGLRDYIMNENEKHLEA 1014
            |:|||:||..|.|:|..:|:|:.....:.:......:.:..:.::.:|..||::|.:...:.:.:
 Frog  1011 LRKDSERRAILYKILNEEENKVSSHLQECLMQSSEDVQLSVTHIKQIISILREFIRSPEHRVMAS 1075

  Fly  1015 TINELKQKLNNDAVALDHLHLALYSFQDAVVCVLRYHCIKPHWMFALDNLVKRAVQAAVTIFSPE 1079
            ||::||..|:.|:.:::.:.|.|:.||||:..|||.|.|:||||||:||:::|||||||||..||
 Frog  1076 TISKLKVDLDFDSTSINQIQLVLFGFQDAINKVLRNHLIRPHWMFAMDNIIRRAVQAAVTILIPE 1140

  Fly  1080 LGANL--------ADKDLSGNDDESLRTSLMQKGSTESQEKQSLEKVLPTSNTREGVGLTPAESG 1136
            |.|:|        .||::...|.:    .::|.|:         |:|:.||.......:...|:.
 Frog  1141 LRAHLGPASESEGVDKEVEDEDYQ----PVVQNGT---------EEVVITSGVSTLSSVVSHETQ 1192

  Fly  1137 GDALSSSM-----ECARILRDIRDNQQKLQ---RQLLEQQRQSMRALHNISQELAHIYMGGRKRL 1193
            |...:..:     |..|::.::...:::.|   :|.|||:...:..|...|..:
 Frog  1193 GQQTNLQLGKLRQETNRLMEELVLKEREYQLILKQCLEQRNHDLHLLQIKSSPI----------- 1246

  Fly  1194 RRTINGFNKKCHRMSTSVGGTSGVRPNIAGNPRRQLNKHHFGLHEVDEQLEQWLTQQEIDEFSKT 1258
                       ...||.|...|..||                   .|::|..||.:...|:....
 Frog  1247 -----------DIPSTPVPYVSHERP-------------------TDQELVNWLRELGADDDVVN 1281

  Fly  1259 LILNEGFTFDDFIYNMEKLDLMRLGLRVGIEVRLWKLIIQER 1300
            ..:.|.:|..:.::::.|.||..|.||.|...|:||.|.:.|
 Frog  1282 QFVEEEYTLYNVLHDITKDDLKSLRLRGGELCRIWKAITKYR 1323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ask1	NP_477089.3	DRHyd-ASK	24..59	CDD:466459	16/34 (47%)
		MAP3K_TRAF_bd	74..445	CDD:463827	174/383 (45%)
		ASK_PH	457..560	CDD:465956	46/102 (45%)
		STKc_ASK	576..843	CDD:270794	190/266 (71%)
		HisK-N-like	948..1079	CDD:466452	49/130 (38%)
map3k15	XP_012812444.1	DRHyd-ASK	85..120	CDD:466459	16/34 (47%)
		MAP3K_TRAF_bd	135..513	CDD:463827	173/382 (45%)
		ASK_PH	524..623	CDD:465956	46/102 (45%)
		STKc_ASK	642..907	CDD:270794	190/266 (71%)
		HisK-N-like	1009..1140	CDD:466452	49/130 (38%)