Protein Alignment Ire1 and Ern1

DIOPT Version :10

• Sequence 1: NP_001097839.1
• Gene: Ire1 / 42358
• FlyBaseID: FBgn0261984
• Length: 1074
• Species: Drosophila melanogaster
• Sequence 2: XP_038942575.1
• Gene: Ern1 / 498013
• RGDID: 1559716
• Length: 982
• Species: Rattus norvegicus
• Alignment Length: 990
• Identity: 386/990 - (38%)
• Similarity: 543/990 - (54%)
• Gaps: 161/990 - (16%)

  Fly    53 EALMVFSTLGGGLTAIDPVTSEIRWTIADDPPIVAEHQENVQVPHFLPDPRDGSIYQLGQMGS-- 115
            |||:..|||.|.|.|:...|..|:||:.:||  |.:...:|:.|.|||||.|||:|.||...:
  Rat    37 EALLFVSTLDGSLHAVSKRTGSIKWTLKEDP--VLQVPTHVEEPAFLPDPNDGSLYTLGGKNNEG 99

  Fly   116 LKKLPYTIPQLVANAPCRSSDGILYSGKKSDTWYMVDPKTGRREKVM--GFGDATVDGKEGEQIG 178
            |.|||:|||:||..:||||||||||.|||.|.||::|..||.:::.:  .|.|:..
  Rat   100 LTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLC--------- 155

  Fly   179 WATSRAIYLGRTQYTVMMYDSLAKNKDAKPWNITFYDYNAVSAPPELAKEYEYIHLTTTTNGQIV 243
             .::..:|||||:||:.|||:  |.::.: ||.|::||.|  :.||...:|:..|..:..:|.:|
  Rat   156 -PSTSLLYLGRTEYTITMYDT--KTRELR-WNATYFDYAA--SLPEDDVDYKMSHFVSNGDGLVV 214

  Fly   244 TLDRKHGKFLWQRDLSSPVVAAFLLGPDGLLSVPFTTVSDEAYQAILEESKTGNVNTV------- 301
            |:|.:.|..||.::.:|||||.::...:||..|....|:.|..:.:...|  |.|..:
  Rat   215 TVDSESGDVLWIQNYASPVVAFYIWQREGLRKVVHINVAVETLRYLTFMS--GEVGRITKWKYPF 277

  Fly   302 --------KLFQSLYVGEHQKGLYALPSLVDKN---TPRISTAPPIKLLDGP------TGDQ--- 346
                    ||..:||||::...|||.||:|.:.   .||.||.|   ||:||      .||:
  Rat   278 PKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLP---LLEGPQTDGVTIGDKGEC 339

  Fly   347 ----NSNQETDP------RTIYINDVLQEHAGIMLGHYNMPNEGNGNLQLSPTTASSKVVQSLAT 401
                :::.:.||      :..|:.:.     .:::||:.           :|.:||:|:::....
  Rat   340 VITPSTDLKFDPGLKGKSKLNYLRNY-----WLLIGHHE-----------TPLSASTKMLERFPN 388

  Fly   402 ---IHNYNDGYGLLANNEKNAADIGVQTDPELVEIGIDQRTNGNTINRTKTIILQNSN------- 456
               .|..|   .:.|::||.:.:       |::.:      .|.|...|.|.:.|:..
  Rat   389 NLPKHREN---VIPADSEKRSFE-------EVINL------VGQTSENTPTTVSQDVEEKLPRAP 437

  Fly   457 -KVQAFINEWFMEHPSGKVHQILIVIVLGMIALFWYTCSTMRELQKQ------------------ 502
             |.:|.::....:..:..:...|:|..:..|..:..:....|:||.|
  Rat   438 AKPEAPVDSMLKDMATIILSTFLLVGWVAFIITYPLSMHQQRQLQHQQFQKELEKIQLLQQQQLP 502

  Fly   503 ---------------------SENGSKTFAIAQNGSNGSTGSNGSNANA-------EDLVDLGNG 539
                                 ..:|:.:.:.:...||.|..|:.|.:.|       .|..|....
  Rat   503 FHPHGDLTQDPDFLDSSGLFSESSGTSSPSPSPRASNHSLNSSSSASKAGTSPSLEPDDEDEETR 567

  Fly   540 QVRVGKISFSTNEVLGKGCEGTFVFKGTFEERFVAVKRLLPECFTFADREVALLRESDAHENVVR 604
            .|.||||||...:|||.|.|||.|:||.|:.|.|||||:|||||:||||||.||||||.|.||:|
  Rat   568 MVIVGKISFCPKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIR 632

  Fly   605 YFCTEQDRQFRYIAVELCAATLQDYTEGDRSLELQNHIDVWQVLSQAASGLSHLHSLDIVHRDIK 669
            |||||:||||:|||:||||||||:|.|......|  .::...:|.|..|||:|||||:|||||:|
  Rat   633 YFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHL--GLEPITLLHQTTSGLAHLHSLNIVHRDLK 695

  Fly   670 PQNVLISLPDAKGKVRVMISDFGLCKKLNFGKTSFSRRSGVTGTDGWIAPEMMR---SQRTTTAV 731
            |.|:|:|:|:|.|:::.|||||||||||..|:.||||||||.||:|||||||:.   .:..|..|
  Rat   696 PHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTV 760

  Fly   732 DIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAKLRPEDDSEDSRIILAEQLISDMIHKD 796
            ||||.|||:|||:|.|:|.||.:|:||||||....:|.... .|..||   ::|.:||..||..|
  Rat   761 DIFSAGCVFYYVISEGNHPFGKSLQRQANILLGACSLDCFH-SDKHED---VIARELIEKMIAMD 821

  Fly   797 PQSRPPARCIGNHPLFWDEPKMLSFLQDVSDRVEKLQFHAEPLKSLEKNGRIVVLDDWNVHLDPM 861
            ||.||.|:.:..||.||...|.|.|.||||||:||.......::.||:.||.||..||..::...
  Rat   822 PQQRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVRQLERGGRAVVKMDWRENITVP 886

  Fly   862 ITDDLRKYRGYMGASVRDLLRALRNKKHHYHELTPAAQKMLGCIPHEFTNYWVDRFPQLISHAYH 926
            :..||||:|.|.|.||||||||:|||:|||.||....|:.||.||.:|..|:..|||.|:||.|.
  Rat   887 LQTDLRKFRTYKGGSVRDLLRAMRNKRHHYRELPLEVQETLGSIPDDFVRYFTSRFPHLLSHTYR 951

  Fly   927 AFSICSNEPIFKPYY 941
            |..:|.:|.:|:.||
  Rat   952 AMELCRHERLFQTYY 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ire1	NP_001097839.1	Luminal_IRE1	53..321	CDD:188875	109/286 (38%)
		STKc_IRE1	545..813	CDD:270884	158/270 (59%)
		RNase_Ire1	817..941	CDD:199217	60/123 (49%)
Ern1	XP_038942575.1	Luminal_IRE1	37..305	CDD:188875	109/286 (38%)
		STKc_IRE1	573..838	CDD:270884	158/270 (59%)
		RNase_Ire1	841..966	CDD:199217	60/124 (48%)