back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ire1 and ERN1

DIOPT Version :10

Sequence 1:	NP_001097839.1	Gene:	Ire1 / 42358	FlyBaseID:	FBgn0261984	Length:	1074	Species:	Drosophila melanogaster
Sequence 2:	NP_001424.3	Gene:	ERN1 / 2081	HGNCID:	3449	Length:	977	Species:	Homo sapiens

Alignment Length:	1028	Identity:	393/1028 - (38%)
Similarity:	556/1028 - (54%)	Gaps:	192/1028 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 EALMVFSTLGGGLTAIDPVTSEIRWTIADDPPIVAEHQENVQVPHFLPDPRDGSIYQLGQMGS-- 115
            |.|:..|||.|.|.|:...|..|:||:.:||  |.:...:|:.|.|||||.|||:|.||...:
Human    30 ETLLFVSTLDGSLHAVSKRTGSIKWTLKEDP--VLQVPTHVEEPAFLPDPNDGSLYTLGSKNNEG 92

  Fly   116 LKKLPYTIPQLVANAPCRSSDGILYSGKKSDTWYMVDPKTGRREKVM--GFGDATVDGKEGEQIG 178
            |.|||:|||:||..:||||||||||.|||.|.||::|..||.:::.:  .|.|:..
Human    93 LTKLPFTIPELVQASPCRSSDGILYMGKKQDIWYVIDLLTGEKQQTLSSAFADSLC--------- 148

  Fly   179 WATSRAIYLGRTQYTVMMYDSLAKNKDAKPWNITFYDYNAVSAPPELAKEYEYIHLTTTTNGQIV 243
             .::..:|||||:||:.|||:  |.::.: ||.|::||.|  :.||...:|:..|..:..:|.:|
Human   149 -PSTSLLYLGRTEYTITMYDT--KTRELR-WNATYFDYAA--SLPEDDVDYKMSHFVSNGDGLVV 207

  Fly   244 TLDRKHGKFLWQRDLSSPVVAAFLLGPDGLLSVPFTTVSDEAYQAILEESKTGNVNTV------- 301
            |:|.:.|..||.::.:|||||.::...:||..|....|:.|..:.:...|  |.|..:
Human   208 TVDSESGDVLWIQNYASPVVAFYVWQREGLRKVMHINVAVETLRYLTFMS--GEVGRITKWKYPF 270

  Fly   302 --------KLFQSLYVGEHQKGLYALPSLVDKN---TPRISTAPPIKLLDGP------TGDQ--- 346
                    ||..:||||::...|||.||:|.:.   .||.||.|   ||:||      .||:
Human   271 PKETEAKSKLTPTLYVGKYSTSLYASPSMVHEGVAVVPRGSTLP---LLEGPQTDGVTIGDKGEC 332

  Fly   347 ----NSNQETDP------RTIYINDVLQEHAGIMLGHYNMPNEGNGNLQLSPTTASSKVVQSLAT 401
                :::.:.||      :..|:.:.     .:::||:.           :|.:||:|:::....
Human   333 VITPSTDVKFDPGLKSKNKLNYLRNY-----WLLIGHHE-----------TPLSASTKMLERFPN 381

  Fly   402 ---IHNYNDGYGLLANNEKNAADIGVQTDPELVEIGIDQRTNGNTINRTKTIILQNSNKVQAFIN 463
               .|..|   .:.|::||.:.:       |::.: :||     |.....|.:.::..:..|..
Human   382 NLPKHREN---VIPADSEKKSFE-------EVINL-VDQ-----TSENAPTTVSRDVEEKPAHA- 429

  Fly   464 EWFMEHPSGKVHQIL---------IVIVLGMIA-LFWYTCST-----------MRELQK------ 501
               ...|...|..:|         ..:::|.:| :..|..|.           .:||:|
Human   430 ---PARPEAPVDSMLKDMATIILSTFLLIGWVAFIITYPLSMHQQQQLQHQQFQKELEKIQLLQQ 491

  Fly   502 --------------------------QSENGSKTFAIAQNGSNGS--TGSNGSNANAEDLVDLGN 538
                                      ...:|:.:.:.:...||.|  :||:.|.|.:...::..:
Human   492 QQQQLPFHPPGDTAQDGELLDTSGPYSESSGTSSPSTSPRASNHSLCSGSSASKAGSSPSLEQDD 556

  Fly   539 GQ-----VRVGKISFSTNEVLGKGCEGTFVFKGTFEERFVAVKRLLPECFTFADREVALLRESDA 598
            |.     |.||||||...:|||.|.|||.|::|.|:.|.|||||:|||||:||||||.||||||.
Human   557 GDEETSVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDE 621

  Fly   599 HENVVRYFCTEQDRQFRYIAVELCAATLQDYTEGDRSLELQNHIDVWQVLSQAASGLSHLHSLDI 663
            |.||:||||||:||||:|||:||||||||:|.|......|  .::...:|.|..|||:|||||:|
Human   622 HPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHL--GLEPITLLQQTTSGLAHLHSLNI 684

  Fly   664 VHRDIKPQNVLISLPDAKGKVRVMISDFGLCKKLNFGKTSFSRRSGVTGTDGWIAPEMMR---SQ 725
            ||||:||.|:|||:|:|.||::.|||||||||||..|:.||||||||.||:|||||||:.   .:
Human   685 VHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKE 749

  Fly   726 RTTTAVDIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAKLRPEDDSEDSRIILAEQLIS 790
            ..|..|||||.|||:|||:|.|.|.||.:|:||||||....:|..|.||...:    ::|.:||.
Human   750 NPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHED----VIARELIE 810

  Fly   791 DMIHKDPQSRPPARCIGNHPLFWDEPKMLSFLQDVSDRVEKLQFHAEPLKSLEKNGRIVVLDDWN 855
            .||..|||.||.|:.:..||.||...|.|.|.||||||:||.......:|.||:.||.||..||.
Human   811 KMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWR 875

  Fly   856 VHLDPMITDDLRKYRGYMGASVRDLLRALRNKKHHYHELTPAAQKMLGCIPHEFTNYWVDRFPQL 920
            .::...:..||||:|.|.|.||||||||:|||||||.||....::.||.:|.:|..|:..|||.|
Human   876 ENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHL 940

  Fly   921 ISHAYHAFSICSNEPIFKPYYSAGYLFTRPWYFDADDALFPMLMLDPKPLPKI 973
            ::|.|.|..:||:|.:|:|||     |..|                |:|.|.:
Human   941 LAHTYRAMELCSHERLFQPYY-----FHEP----------------PEPQPPV 972

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.