Protein Alignment Ire1 and ERN2

DIOPT Version :10

• Sequence 1: NP_001097839.1
• Gene: Ire1 / 42358
• FlyBaseID: FBgn0261984
• Length: 1074
• Species: Drosophila melanogaster
• Sequence 2: NP_150296.4
• Gene: ERN2 / 10595
• HGNCID: 16942
• Length: 926
• Species: Homo sapiens
• Alignment Length: 971
• Identity: 376/971 - (38%)
• Similarity: 510/971 - (52%)
• Gaps: 162/971 - (16%)

  Fly    53 EALMVFSTLGGGLTAIDPVTSEIRWTIADDPPIVAEHQENVQVPHFLPDPRDGSIYQLG---QMG 114
            |.|::.|||.|.|.|:...|.:::||:.|||  |.|....|....||.||.|||:|.||   |.|
Human    38 ENLLLVSTLDGSLHALSKQTGDLKWTLRDDP--VIEGPMYVTEMAFLSDPADGSLYILGTQKQQG 100

  Fly   115 SLKKLPYTIPQLVANAPCRSSDGILYSGKKSDTWYMVDPKTGRREKVMGFGDATVDGKEGEQIGW 179
             |.|||:|||:||..:|||||||:.|:|:|.|.|::|||::|..:..:     |.:|.
Human   101 -LMKLPFTIPELVHASPCRSSDGVFYTGRKQDAWFVVDPESGETQMTL-----TTEGP------- 152

  Fly   180 ATSRAIYLGRTQYTVMMYDSLAKNKDAKPWNITFYDYNAVSAPPELAKEYEYI-HLTTTTNGQIV 243
            :|.| :|:|||||||.|:|..|   .|..||.|:..|   ||||......:|: ||.:...|.::
Human   153 STPR-LYIGRTQYTVTMHDPRA---PALRWNTTYRRY---SAPPMDGSPGKYMSHLASCGMGLLL 210

  Fly   244 TLDRKHGKFLWQRDLSSPVVAAFLLGPDGLLSVPFTTVSDEAYQAI------LEESKTGNVNTVK 302
            |:|...|..||.:||..||:..:....|||..:|..|::.:....:      :....:|..:|..
Human   211 TVDPGSGTVLWTQDLGVPVMGVYTWHQDGLRQLPHLTLARDTLHFLALRWGHIRLPASGPRDTAT 275

  Fly   303 LF--------QSLYVGEHQKGLYALPSLVDKN---TPRISTAPPIKLLDGPTGDQ-----NSNQE 351
            ||        .:||||:.:.|.|...:||...   .||..|..|   .||||.|:     :..:|
Human   276 LFSTLDTQLLMTLYVGKDETGFYVSKALVHTGVALVPRGLTLAP---ADGPTTDEVTLQVSGERE 337

  Fly   352 TDPRTIY---INDVLQEHAGIMLGHYNMPNEGNGN-LQLSPTTASSKVVQSLATIHNYNDGYGLL 412
            ..|.|..   ...|......:::||:.:|...:.. |::.||..|..
Human   338 GSPSTAVRYPSGSVALPSQWLLIGHHELPPVLHTTMLRVHPTLGSGT------------------ 384

  Fly   413 ANNEKNAADIGVQTDPELVEIGIDQRTNGNTINRTKTIILQNSNKVQAFINE---------WFME 468
                       .:|.|                        ..:.:..||..|         |..|
Human   385 -----------AETRP------------------------PENTQAPAFFLELLSLSREKLWDSE 414

  Fly   469 -HPSGKV--------HQILIVIVLGMIALFWYTCSTMRE-----LQKQSEN--GSKTFA-IAQNG 516
             ||..|.        .|.|:...|..:.|..:....||:     ::||.|.  ....|| |:|:.
Human   415 LHPEEKTPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAHISQDA 479

  Fly   517 SNGSTGSN--------GSNANAEDLVDLGNGQVR-VGKISFSTNEVLGKGCEGTFVFKGTFEERF 572
            .:..:|::        ..:..|:.|.|....|:. ||||||:..:|||:|..|||||:|.||.|.
Human   480 QSLHSGASRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTFVFRGQFEGRA 544

  Fly   573 VAVKRLLPECFTFADREVALLRESDAHENVVRYFCTEQDRQFRYIAVELCAATLQDYTEG---DR 634
            |||||||.|||....|||.||:|||.|.||:||||||:..||.|||:|||.|:||:|.|.   ||
Human   545 VAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVENPDLDR 609

  Fly   635 -SLELQNHIDVWQVLSQAASGLSHLHSLDIVHRDIKPQNVLISLPDAKGKVRVMISDFGLCKKLN 698
             .||.:      .||.|..|||:|||||.|||||:||.|:||:.||::|..||::|||||||||.
Human   610 GGLEPE------VVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLP 668

  Fly   699 FGKTSFSRRSGVTGTDGWIAPEMMR---SQRTTTAVDIFSLGCVYYYVLSGGHHAFGDNLKRQAN 760
            .|:.|||..||:.||:||:|||:::   ....|:||||||.|||:|||||||.|.|||:|.||||
Human   669 AGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQAN 733

  Fly   761 ILSHEYNLAKLRPEDDSEDSRIILAEQLISDMIHKDPQSRPPARCIGNHPLFWDEPKMLSFLQDV 825
            ||:....||.|  |::..|.  ::|..|:..|:...||.||.|..:..||.||...|.|.|.|||
Human   734 ILTGAPCLAHL--EEEVHDK--VVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQLQFFQDV 794

  Fly   826 SDRVEKLQFHAEPL-KSLEKNGRIVVLDDWNVHLDPMITDDLRKYRGYMGASVRDLLRALRNKKH 889
            ||.:|| :...||| ::||..|..||.|:|:.|:...:..||||:|.|.|.||||||||:|||||
Human   795 SDWLEK-ESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRSYKGTSVRDLLRAVRNKKH 858

  Fly   890 HYHELTPAAQKMLGCIPHEFTNYWVDRFPQLISHAYHAFSICSNEPIFKPYYSAGYLFTRP 950
            ||.||....::.||.:|..|..|:.:|||:|:.|.:.|...|::|.:|.|||.......||
Human   859 HYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSCASESLFLPYYPPDSEARRP 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ire1	NP_001097839.1	Luminal_IRE1	53..321	CDD:188875	106/285 (37%)
		STKc_IRE1	545..813	CDD:270884	152/274 (55%)
		RNase_Ire1	817..941	CDD:199217	60/124 (48%)
ERN2	NP_150296.4	Luminal_IRE1	38..366	CDD:188875	123/352 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	478..509		4/30 (13%)
		STKc_IRE1	517..782	CDD:270884	152/274 (55%)
		RNase_Ire1	785..910	CDD:199217	60/125 (48%)