Protein Alignment Acsx1L and ACSS3

DIOPT Version :10

• Sequence 1: NP_650828.1
• Gene: Acsx1L / 42351
• FlyBaseID: FBgn0038730
• Length: 537
• Species: Drosophila melanogaster
• Sequence 2: NP_078836.1
• Gene: ACSS3 / 79611
• HGNCID: 24723
• Length: 686
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 135/613 - (22%)
• Similarity: 236/613 - (38%)
• Gaps: 130/613 - (21%)

  Fly     2 PYTP--ENSYDNDQKIWSGEPVVKYFDPDLSIGEIIFHEMRRHPQ----------LTAQISATEG 54
            |:|.  ||.:         .|..::|...:.  .|.::.:.||.:          ..:.::.|:.
Human    89 PWTKTLENKH---------SPSTRWFVEGML--NICYNAVDRHIENGKGDKIAIIYDSPVTNTKA 142

  Fly    55 TVLTRGELLANAMRLASYMRSLGLLQSDIVGI----IGRNTTHMLAVA-----YACFFNGIAFHS 110
            | .|..|:|....:||..:...|:.:.|.|.|    |.:....|||.|     ::..|.|.|...
Human   143 T-FTYKEVLEQVSKLAGVLVKHGIKKGDTVVIYMPMIPQAMYTMLACARIGAIHSLIFGGFASKE 206

  Fly   111 LNITYDRDTIEKIYKVTRPSIIFC------DGDEFEKVRSATAELDV------KIVTMRNHPLDS 163
            |:...|.         .:|.::..      .|...|.|......|.:      ||:......:::
Human   207 LSSRIDH---------VKPKVVVTASFGIEPGRRVEYVPLVEEALKIGQHKPDKILIYNRPNMEA 262

  Fly   164 IKI--------DEVVATPIEENFQPAKLEKGNDQTLAILCSSGTTGTPKAVTITNSRHI------ 214
            :.:        ||.:|.....:..|..    ::..|.||.:|||||.||.|......:.
Human   263 VPLAPGRDLDWDEEMAKAQSHDCVPVL----SEHPLYILYTSGTTGLPKGVIRPTGGYAVMLHWS 323

  Fly   215 LAGNYHLTTADVQYSHNTLDWITG--------LL---TTI--------TSGVFSTTRIIADNA-- 258
            ::..|.|...:|.::.:.|.|:.|        ||   ||:        |....:..|::|::.
Human   324 MSSIYGLQPGEVWWAASDLGWVVGHSYICYGPLLHGNTTVLYEGKPVGTPDAGAYFRVLAEHGVA 388

  Fly   259 --FDPAFALRIIEEYKVTWTIQPPSSMALMINCPDFETCDMSSLRCYMFGGSRAALEVQKGI--R 319
              |....|:|.|.:.      .|.:::....:...|:|..::..||.:     ..||..|.:  .
Human   389 ALFTAPTAIRAIRQQ------DPGAALGKQYSLTRFKTLFVAGERCDV-----ETLEWSKNVFRV 442

  Fly   320 SRLSHDCLQFVYGFTELGAMATINC--HFDEKT---GSVGQLVNGLKMKIINDDGESLGPDEIGE 379
            ..|.|      :..||.|:..|.:|  ..:.||   |..|:.|.|..:.|::|:.:.|....:|.
Human   443 PVLDH------WWQTETGSPITASCVGLGNSKTPPPGQAGKSVPGYNVMILDDNMQKLKARCLGN 501

  Fly   380 VCI---MNNQHWSGYYGNEVETRNM--RDSLGWYHSGDLGYMDRDGFLYIMDRKKEMLKYQNIMY 439
            :.:   :....:||.:.|:...:::  ....|:|.:.|.||||.:|:||:|.|..:::.......
Human   502 IVVKLPLPPGAFSGLWKNQEAFKHLYFEKFPGYYDTMDAGYMDEEGYLYVMSRVDDVINVAGHRI 566

  Fly   440 YPNDIESVISEMPQVAEVCVFGIWSNIFGD-EAAAAVVKKLGSELEAQ---DVVDYVRSRTDSKY 500
            ....||..|.....||:..|.|....:.|. ..|..|::|..:..|.|   ::|.:||.......
Human   567 SAGAIEESILSHGTVADCAVVGKEDPLKGHVPLALCVLRKDINATEEQVLEEIVKHVRQNIGPVA 631

  Fly   501 KQLNGGAVIVDDLQRSANGKTNRMANKA 528
            ...|  ||.|..|.::.:||..|.|..|
Human   632 AFRN--AVFVKQLPKTRSGKIPRSALSA 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Acsx1L	NP_650828.1	Firefly_Luc_like	47..522	CDD:341237	123/548 (22%)
ACSS3	NP_078836.1	PrpE	62..679	CDD:341271	135/613 (22%)