DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Naam and PNC1

DIOPT Version :9

Sequence 1:	NP_001262738.1	Gene:	Naam / 42348	FlyBaseID:	FBgn0051216	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_011478.3	Gene:	PNC1 / 852846	SGDID:	S000003005	Length:	216	Species:	Saccharomyces cerevisiae

Alignment Length:	231	Identity:	71/231 - (30%)
Similarity:	110/231 - (47%)	Gaps:	45/231 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 VNAFLIVDVQNDFIS--GSLDISNCSAQQQGHEILEPINKLLDTVDFD--AVFYSLDWHPSDHVS 156
            :...::||:||||||  |||.:      .:|.|::.||:.|:...|.|  .:..:.|||||.|:|
Yeast     1 MKTLIVVDMQNDFISPLGSLTV------PKGEELINPISDLMQDADRDWHRIVVTRDWHPSRHIS 59

  Fly   157 FIDNVKMRPMDESSALDSDSAKVFDTVIFAGPPP-----MKQRLWPRHCVQDSWGAEL------- 209
            |..|.|             ..:.:.|..:..|.|     .:..|||.|||:::||::|
Yeast    60 FAKNHK-------------DKEPYSTYTYHSPRPGDDSTQEGILWPVHCVKNTWGSQLVDQIMDQ 111

  Fly   210 --HKDLKVVDHGIKVYKGTNPEVDSYSVFWDNKKLSDTTLNAQLKMKGATDIYVCGLAYDVCVGA 272
              .|.:|:||      ||...:.:.||.|.|......|.:|..|:.....::|:.|:|.:.||.|
Yeast   112 VVTKHIKIVD------KGFLTDREYYSAFHDIWNFHKTDMNKYLEKHHTDEVYIVGVALEYCVKA 170

  Fly   273 TAVDALSAGYRTILIDDCCR--GTDVHDIEHTKEKV 306
            ||:.|...||:|.::.|..|  ..|...|...||::
Yeast   171 TAISAAELGYKTTVLLDYTRPISDDPEVINKVKEEL 206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Naam	NP_001262738.1	EFh	20..81	CDD:238008
		EF-hand_7	21..82	CDD:290234
		nicotinamidase	97..315	CDD:238493	71/230 (31%)
PNC1	NP_011478.3	nicotinamidase	1..214	CDD:238493	71/231 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	103	1.000	Domainoid score	I1500
eggNOG	1	0.900	-	-		E1_COG1335
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5938
Inparanoid	1	1.050	104	1.000	Inparanoid score	I1426
Isobase	1	0.950	-	0	Normalized mean entropy	S12195
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007602
OrthoInspector	1	1.000	-	-		oto100159
orthoMCL	1	0.900	-	-		OOG6_100439
Panther	1	1.100	-	-	LDO	PTHR11080
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16483
SonicParanoid	1	1.000	-	-		X6476
TreeFam	0	0.000	Not matched by this tool.
	12	11.840