Protein Alignment Naam and ISOC1

DIOPT Version :10

• Sequence 1: NP_732446.1
• Gene: Naam / 42348
• FlyBaseID: FBgn0051216
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_057132.2
• Gene: ISOC1 / 51015
• HGNCID: 24254
• Length: 298
• Species: Homo sapiens
• Alignment Length: 370
• Identity: 69/370 - (18%)
• Similarity: 121/370 - (32%)
• Gaps: 138/370 - (37%)

  Fly     3 SPTPPIVIEDSNGSAMDACFTAFDKDSDDRLSL---AEFSIICRALFRNDKGHIYDVPPERLEQI 64
            |.|.|::.          ||:.|.:.|    |:   |.:.::.:. |.:..|...|:..:.:.|:
Human    23 SGTVPVLF----------CFSVFARPS----SVPHGAGYELLIQK-FLSLYGDQIDMHRKFVVQL 72

  Fly    65 FAVFDTNGDGFIDREEFKFCWNQWIKTIVRPVNAFLIVDVQNDFISGSLDISNCSAQQQGHEILE 129
            ||            ||    |.|::                 |...|......|..:      |.
Human    73 FA------------EE----WGQYV-----------------DLPKGFAVSERCKVR------LV 98

  Fly   130 PINKLLDTVDFDAVFYSLDWHPSDHVSFIDNV--KMRPMDESSALDSDSAKVFDTVIFAGPPPMK 192
            |:...|.|:.        :..||..|.|..::  :.||          :.|.|..:|..|
Human    99 PLQIQLTTLG--------NLTPSSTVFFCCDMQERFRP----------AIKYFGDIISVG----- 140

  Fly   193 QRLWPRH-------CVQDSWGAELHKDLKVVD-HGIKV------YKGTNPEVDSYSVFWDNKKLS 243
            |||....       .|.:.:...|...::.:| .|:|:      :....|||::
Human   141 QRLLQGARILGIPVIVTEQYPKGLGSTVQEIDLTGVKLVLPKTKFSMVLPEVEA----------- 194

  Fly   244 DTTLNAQLKMKGATDIYVCGLAYDVCVGATAVDALSAGYRTILIDDCCRGTDVHDIEHTKEK--- 305
                 |..::.|...:.:.|:...||:..||::.:..|....::.|......:.|.....|:
Human   195 -----ALAEIPGVRSVVLFGVETHVCIQQTALELVGRGVEVHIVADATSSRSMMDRMFALERLAR 254

  Fly   306 ----VNTSDGVIVH-------------TNQVKAMAEGRDRRPELG 333
                |.||:.|::.             .|.:||.|      ||.|
Human   255 TGIIVTTSEAVLLQLVADKDHPKFKEIQNLIKASA------PESG 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Naam	NP_732446.1	FRQ1	<11..82	CDD:444056	14/73 (19%)
		nicotinamidase	97..315	CDD:238493	43/240 (18%)
ISOC1	NP_057132.2	YcaC_related	116..270	CDD:238494	34/184 (18%)