DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup58 and Nup58

DIOPT Version :9

Sequence 1:	NP_650821.2	Gene:	Nup58 / 42342	FlyBaseID:	FBgn0038722	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_620791.1	Gene:	Nup58 / 245922	RGDID:	631334	Length:	585	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	169/549 - (30%)
Similarity:	251/549 - (45%)	Gaps:	113/549 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 ATG-AFAFGARPATTTAPPP-------SFGAATSTPTFGAAPATTSLFAAPAATPAFGAPAATPA 72
            ||| :|..|...:||.||..       ||| |:|||:.|....|....|.||:|....:...|..
  Rat     2 ATGFSFGSGTLGSTTVAPGGTGTGSGFSFG-ASSTPSVGLNFGTLGSSATPASTSTSASGFGTGL 65

  Fly    73 FGAPASTPGFGATSTAAPAFGTAAATPAFGIPAATSAFGAPAATPAFGAAAATPAFGAP-AATPA 136
            ||   |.||.|.|.....| ||.|.|     .|:|:.|....:.|   ||:||| |..| .:|.|
  Rat    66 FG---SKPGTGFTLGGTSA-GTTATT-----SASTTGFSLGFSKP---AASATP-FALPVTSTTA 117

  Fly   137 FGAPAATSAFGAPAATTAFGAPASTQASAFGAPAPAVGTVAPTFSFATPATSAPTTAPPAFGFGT 201
            .|...:::...||||:|.|      ..:..|               |||||             |
  Rat   118 SGLTLSSALTSAPAASTGF------TLNNLG---------------ATPAT-------------T 148

  Fly   202 TATTAAAAMPASLSSGIGSFSFPKPQATTAASLNFNTTTTTATAQPFNTGLKLGTTNATTTLGGG 266
            ||.:...::..:| :|:|...|                      |..||        ||:.||..
  Rat   149 TAASTGLSLGGAL-AGLGGSLF----------------------QSGNT--------ATSGLGQN 182

  Fly   267 GIFSKPAGQAAAPAASTFVGLGGIDVTAT----QPKLGDNKQDGIKIKETQVPDEIIKTVDGLKA 327
            .: |...|.|...:|::..||||||.:.:    ..|.|...:|...:|:..:|..|.:.|:.|:.
  Rat   183 AL-SLSLGTATPTSAASSEGLGGIDFSTSSDKKSDKTGTRPEDSKALKDENLPPVICQDVENLQK 246

  Fly   328 YIKQQKTISSDIGRTSTSKFTNVSHEITNLKWALQNMATLVEGSNQQIRLMRQETVKAIQSLEMA 392
            ::|:||.:..:|.|.|:.....|..:|..||..|...|:.::.:...|..::.||.:.:::.|:|
  Rat   247 FVKEQKQVQEEISRMSSKAMLKVQEDIKALKQLLSLAASGLQRNTLNIDKLKLETAQELKNAEIA 311

  Fly   393 QRTQDTPAGLQFENNAPFQYFQCLVAKYEQDLIAFRQQIALTERHMHAISNPQSISPDDLKRGFR 457
            .|||.||.|||.||.||..||:.||.::|..|..:||||...|.|:...:|...|:|.||....:
  Rat   312 LRTQKTPPGLQHENTAPADYFRVLVQQFEVQLQQYRQQIEELENHLATQANNSHITPQDLSMAMQ 376

  Fly   458 QLNESFISLAGRLHEVHQRVEEHKEHYLNLRRYRLRDTTNVFE-------RIDNPPLPTVEPQRI 515
            ::.::|::||.:|..:|:.|:..||.||:.|:..|.|..:|||       :..|.|       |:
  Rat   377 KIYQTFVALAAQLQSIHENVKVLKEQYLSYRKMFLGDAGDVFEARRTEAKKWQNAP-------RV 434

  Fly   516 SSGPTPFSNISALMNKSYAAAASSASNAT 544
            ::||||||.:      ..|||.:.|:..|
  Rat   435 TTGPTPFSTM------PNAAAVAMAATLT 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup58	NP_650821.2	PHA03247	<25..195	CDD:223021	56/177 (32%)
Nup58	NP_650821.2	Nucleoporin_FG2	136..>525	CDD:374260	117/399 (29%)
Nup58	NP_620791.1	14 X 2 AA repeats of F-G	7..565		165/543 (30%)
		Nucleoporin_FG2	32..585	CDD:292589	153/511 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..232		4/37 (11%)
		DUF2362	230..>408	CDD:287163	58/181 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..585
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347606
Domainoid	1	1.000	194	1.000	Domainoid score	I3087
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	195	1.000	Inparanoid score	I3751
OMA	1	1.010	-	-		QHG52677
OrthoDB	1	1.010	-	-		D379076at33208
OrthoFinder	1	1.000	-	-		FOG0006833
OrthoInspector	1	1.000	-	-		oto97829
orthoMCL	1	0.900	-	-		OOG6_105706
Panther	1	1.100	-	-	LDO	PTHR13437
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.870