DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nup58 and npp-11

DIOPT Version :9

Sequence 1:	NP_650821.2	Gene:	Nup58 / 42342	FlyBaseID:	FBgn0038722	Length:	546	Species:	Drosophila melanogaster
Sequence 2:	NP_491232.1	Gene:	npp-11 / 171954	WormBaseID:	WBGene00003797	Length:	805	Species:	Caenorhabditis elegans

Alignment Length:	690	Identity:	201/690 - (29%)
Similarity:	266/690 - (38%)	Gaps:	220/690 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TPTTNNAIGGATAATGAFAFG-ARPATTTAPPPSFGAATSTPT-FGA------APATTSLFA--- 56
            |.|.|.  ||.|..||.|:|| |:|:|.:.  ..||.:|:|.: ||.      |||:..:|.
Worm    32 TSTANT--GGNTNTTGGFSFGSAQPSTGST--GLFGNSTATGSMFGGSSAAAPAPASAGIFGNSG 92

  Fly    57 ----APAATPAFGAPA-----ATPAFGAPASTPG---FGATSTAAPA------------------ 91
                |||:|..||:.|     ||..|||.|.:.|   |||...|||.
Worm    93 AAAPAPASTSIFGSSANSAAPATVTFGASAPSAGAGMFGANKPAAPTGGLFGSSTSTATTAPTGG 157

  Fly    92 -FGTAAATPAFGIPAATSA----------------------FGAPAA----TPA-----FGAAAA 124
             ||::.|.|:.|:..:|:|                      ||:.||    .||     ||||.|
Worm   158 LFGSSTAAPSSGLFGSTAAPAAPGGLFGSTSTSTAAPSGGLFGSSAAPTSTAPAPSGGLFGAAPA 222

  Fly   125 T----PAFG-----APAATPA----FGA---PAATSA--FG--APAATTA--------FGAPAST 161
            |    |..|     |||||.:    |||   |||.|.  ||  |||.|.|        ||||.|.
Worm   223 TSNAAPTSGLFGNSAPAATASSGGLFGAAPKPAAPSGGLFGSTAPATTAATTTATSGLFGAPTSA 287

  Fly   162 QASA------FG---APAPAVGTV---------APTF------SFATPATSAPTTAPPAFGFGTT 202
            .:||      ||   |||.|.|.:         .|:.      |.:|.|.:||.|||.|...|..
Worm   288 PSSAPATGGLFGASTAPAAATGGLFSIGAASASTPSVGLFGNSSASTTAAAAPATAPAAASTGGL 352

  Fly   203 --ATTAAAAMPASLSSG-------------------IGSFSFPKPQATTAASLNFNTTTTTATAQ 246
              |||||||.|.|.::|                   .||.:..|..|...|.| |..::||.|:.
Worm   353 FGATTAAAAAPTSSTTGGLFGSTAAAPAASLPTGGLFGSSTPAKTPAAPTAGL-FGASSTTTTSA 416

  Fly   247 PFNTGLKLGTTNATTT---------LGG----------------GGIF---SKPAGQAAAP---- 279
            | .||...||..||||         .||                ||:|   :..|..||||
Worm   417 P-ATGSLFGTAPATTTATSAAPAASTGGLFGASSTTTPASTAPTGGLFGAATTTAPAAAAPTGGL 480

  Fly   280 --AASTFV--------GLGGIDVTATQPKLGDNKQDGIKIKETQVPDEIIKTVDGLKAYIKQQKT 334
              ||:|..        ||.|...|.|........|....:..|........|...|....:...|
Worm   481 FGAATTTAPATVGPTGGLFGAATTTTPATAATLGQTPSTVSATPSLPTTTSTTSTLPKPAEATPT 545

  Fly   335 ISSDIGRTSTSKFTNVSHEITNLKWALQNMATLVEGSNQQIRLMRQETVKAIQSLEMAQRTQDTP 399
            :...:|.|||..........:.||.|....|.|..|::....|..:| :||      .....||.
Worm   546 LGLGLGLTSTPLAKGTGWTTSGLKGAATTSAGLKIGASGSDTLSEEE-IKA------GLGGNDTK 603

  Fly   400 A---GLQFENNAPFQYFQCLVAKYEQ-------DLIAFRQQIALTERHMHAISNPQSISPDDLKR 454
            |   .||...|:    :...:||.|:       :|.|:.:::...|..:..:.|..    |||..
Worm   604 AFFTALQEVVNS----YHSEIAKQERVFHNKMLELNAYDRELITLEPKVLGLYNEM----DDLSG 660

  Fly   455 GFRQLNESFISLAGRLHEVHQRVEEHKEHYLNLRRYRLRD 494
            ..::|:.:..|:...|:::.|.|.| .|:.|:|..:...|
Worm   661 SCKKLHFNVASMTSVLNDIEQNVVE-LENKLSLPEWHTLD 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup58	NP_650821.2	PHA03247	<25..195	CDD:223021	94/293 (32%)
Nup58	NP_650821.2	Nucleoporin_FG2	136..>525	CDD:374260	131/475 (28%)
npp-11	NP_491232.1	Nucleoporin_FG	117..218	CDD:290362	24/100 (24%)
npp-11	NP_491232.1	Nucleoporin_FG	220..328	CDD:290362	39/107 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0845
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R852
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930