Protein Alignment Nup58 and npp-11

DIOPT Version :10

• Sequence 1: NP_650821.2
• Gene: Nup58 / 42342
• FlyBaseID: FBgn0038722
• Length: 546
• Species: Drosophila melanogaster
• Sequence 2: NP_491232.1
• Gene: npp-11 / 171954
• WormBaseID: WBGene00003797
• Length: 805
• Species: Caenorhabditis elegans
• Alignment Length: 690
• Identity: 201/690 - (29%)
• Similarity: 266/690 - (38%)
• Gaps: 220/690 - (31%)

  Fly     3 TPTTNNAIGGATAATGAFAFG-ARPATTTAPPPSFGAATSTPT-FGA------APATTSLFA--- 56
            |.|.|.  ||.|..||.|:|| |:|:|.:.  ..||.:|:|.: ||.      |||:..:|.
 Worm    32 TSTANT--GGNTNTTGGFSFGSAQPSTGST--GLFGNSTATGSMFGGSSAAAPAPASAGIFGNSG 92

  Fly    57 ----APAATPAFGAPA-----ATPAFGAPASTPG---FGATSTAAPA------------------ 91
                |||:|..||:.|     ||..|||.|.:.|   |||...|||.
 Worm    93 AAAPAPASTSIFGSSANSAAPATVTFGASAPSAGAGMFGANKPAAPTGGLFGSSTSTATTAPTGG 157

  Fly    92 -FGTAAATPAFGIPAATSA----------------------FGAPAA----TPA-----FGAAAA 124
             ||::.|.|:.|:..:|:|                      ||:.||    .||     ||||.|
 Worm   158 LFGSSTAAPSSGLFGSTAAPAAPGGLFGSTSTSTAAPSGGLFGSSAAPTSTAPAPSGGLFGAAPA 222

  Fly   125 T----PAFG-----APAATPA----FGA---PAATSA--FG--APAATTA--------FGAPAST 161
            |    |..|     |||||.:    |||   |||.|.  ||  |||.|.|        ||||.|.
 Worm   223 TSNAAPTSGLFGNSAPAATASSGGLFGAAPKPAAPSGGLFGSTAPATTAATTTATSGLFGAPTSA 287

  Fly   162 QASA------FG---APAPAVGTV---------APTF------SFATPATSAPTTAPPAFGFGTT 202
            .:||      ||   |||.|.|.:         .|:.      |.:|.|.:||.|||.|...|..
 Worm   288 PSSAPATGGLFGASTAPAAATGGLFSIGAASASTPSVGLFGNSSASTTAAAAPATAPAAASTGGL 352

  Fly   203 --ATTAAAAMPASLSSG-------------------IGSFSFPKPQATTAASLNFNTTTTTATAQ 246
              |||||||.|.|.::|                   .||.:..|..|...|.| |..::||.|:.
 Worm   353 FGATTAAAAAPTSSTTGGLFGSTAAAPAASLPTGGLFGSSTPAKTPAAPTAGL-FGASSTTTTSA 416

  Fly   247 PFNTGLKLGTTNATTT---------LGG----------------GGIF---SKPAGQAAAP---- 279
            | .||...||..||||         .||                ||:|   :..|..||||
 Worm   417 P-ATGSLFGTAPATTTATSAAPAASTGGLFGASSTTTPASTAPTGGLFGAATTTAPAAAAPTGGL 480

  Fly   280 --AASTFV--------GLGGIDVTATQPKLGDNKQDGIKIKETQVPDEIIKTVDGLKAYIKQQKT 334
              ||:|..        ||.|...|.|........|....:..|........|...|....:...|
 Worm   481 FGAATTTAPATVGPTGGLFGAATTTTPATAATLGQTPSTVSATPSLPTTTSTTSTLPKPAEATPT 545

  Fly   335 ISSDIGRTSTSKFTNVSHEITNLKWALQNMATLVEGSNQQIRLMRQETVKAIQSLEMAQRTQDTP 399
            :...:|.|||..........:.||.|....|.|..|::....|..:| :||      .....||.
 Worm   546 LGLGLGLTSTPLAKGTGWTTSGLKGAATTSAGLKIGASGSDTLSEEE-IKA------GLGGNDTK 603

  Fly   400 A---GLQFENNAPFQYFQCLVAKYEQ-------DLIAFRQQIALTERHMHAISNPQSISPDDLKR 454
            |   .||...|:    :...:||.|:       :|.|:.:::...|..:..:.|..    |||..
 Worm   604 AFFTALQEVVNS----YHSEIAKQERVFHNKMLELNAYDRELITLEPKVLGLYNEM----DDLSG 660

  Fly   455 GFRQLNESFISLAGRLHEVHQRVEEHKEHYLNLRRYRLRD 494
            ..::|:.:..|:...|:::.|.|.| .|:.|:|..:...|
 Worm   661 SCKKLHFNVASMTSVLNDIEQNVVE-LENKLSLPEWHTLD 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup58	NP_650821.2	PHA03247	<25..195	CDD:223021	94/293 (32%)
		Nucleoporin_FG2	136..>525	CDD:435043	131/475 (28%)
npp-11	NP_491232.1	FhaB	<13..602	CDD:442443	175/582 (30%)
		PRK07003	<122..>319	CDD:235906	62/196 (32%)