Protein Alignment CG7342 and SV2B

DIOPT Version :10

• Sequence 1: NP_650815.2
• Gene: CG7342 / 42335
• FlyBaseID: FBgn0038716
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_055663.1
• Gene: SV2B / 9899
• HGNCID: 16874
• Length: 683
• Species: Homo sapiens
• Alignment Length: 662
• Identity: 130/662 - (19%)
• Similarity: 215/662 - (32%)
• Gaps: 247/662 - (37%)

  Fly     3 EVDKILEKCGDFSRLQMIMLLLFCVINVLSALHYYSQTIISFVPKYWCADGLPASIESPVDSSCL 67
            :.:.|:::|| ..|.|.|   ||.|:.:  ||               .|||    :|..|.|..|
Human    94 QYETIMDECG-HGRFQWI---LFFVLGL--AL---------------MADG----VEVFVVSFAL 133

  Fly    68 PLNRNISTPNTCYSYNYELYMGYQSFPSEMDWVCADAWKLTLGQSMFFVGSVVGSMVLGYLADVV 132
            |                         .:|.|...:.:.|..||. :.::|.:.|:.:||.|||.:
Human   134 P-------------------------SAEKDMCLSSSKKGMLGM-IVYLGMMAGAFILGGLADKL 172

  Fly   133 GRLPILIVANLIAMTGNLLTIWS----TNVTLFCMFRMISGIATDSNFVMMYILVMEYMRPSVRT 193
            ||..:|.::  :|:..:..::.|    ....|||  |:||||.......:::....|::....|.
Human   173 GRKRVLSMS--LAVNASFASLSSFVQGYGAFLFC--RLISGIGIGGALPIVFAYFSEFLSREKRG 233

  Fly   194 LGLSICIGFFYCLGSM---AAPWIAV-------------LMRSWRGFLLTTSLPLLVVPFFYLIV 242
            ..|| .:|.|:..|.:   |..|..:             ...|||.|::..:||..|.......:
Human   234 EHLS-WLGIFWMTGGLYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPCTVSMVALKFM 297

  Fly   243 PESIQWLISKQKYDSAVVCLKRVAKIN--GRHVEESAYA-----------EFIE----------- 283
            |||.::|:...|:|.|.:.||:|...|  .:...|..:.           ||||
Human   298 PESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSNIKTPKQMDEFIEIQSSTGTWYQR 362

  Fly   284 -----------------ECKCSQQNQKA--------------------SPHLLDLFQTPRLRRHT 311
                             .|.........                    .|.::..||....:...
Human   363 WLVRFKTIFKQVWDNALYCVMGPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQDEEYKSKM 427

  Fly   312 LILF-------------------------------------FKSMVITLCY-------DAVSRNV 332
            .:.|                                     |:......||       |...:|.
Human   428 KVFFGEHVYGATINFTMENQIHQHGKLVNDKFTRMYFKHVLFEDTFFDECYFEDVTSTDTYFKNC 492

  Fly   333 -------------------------------QGLGI-----SPFVMFSLS---ATAILPACLLII 358
                                           :|..:     :.|:::.:|   :.::||..::..
Human   493 TIESTIFYNTDLYEHKFINCRFINSTFLEQKEGCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISA 557

  Fly   359 ALQDRIGRKAMASASLLLSGI--FISVTGGIIFAASASDKTTTLLVSLSVVGRFGVTVAYNSGAQ 421
            .|.|||||..|...|:|:|.:  |....|.   :.||......|....|:       .|:|:...
Human   558 LLMDRIGRLKMIGGSMLISAVCCFFLFFGN---SESAMIGWQCLFCGTSI-------AAWNALDV 612

  Fly   422 YATELIPTCVRGQGVAAVH-------VAGYAFTFFSAYILFTRSVFSPLPEIILGVLSLL-GACL 478
            ...||.||..|......::       :.|.  |.|::::..|:.|     .|:|...||: |..:
Human   613 ITVELYPTNQRATAFGILNGLCKFGAILGN--TIFASFVGITKVV-----PILLAAASLVGGGLI 670

  Fly   479 CLLLPETLHRTL 490
            .|.||||..:.|
Human   671 ALRLPETREQVL 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_650815.2	2A0119	12..491	CDD:273328	128/653 (20%)
SV2B	NP_055663.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42
		synapt_SV2	8..683	CDD:130366	130/662 (20%)