DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7342 and Slc22a22

DIOPT Version :9

Sequence 1:	NP_001247196.1	Gene:	CG7342 / 42335	FlyBaseID:	FBgn0038716	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001013969.1	Gene:	Slc22a22 / 299944	RGDID:	1304605	Length:	555	Species:	Rattus norvegicus

Alignment Length:	584	Identity:	138/584 - (23%)
Similarity:	249/584 - (42%)	Gaps:	95/584 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DKILEKCGDFSRLQMIMLLLFCVINVLSALHYYSQTIISFVPKYWCADGLPASIESPVDSS---- 65
            |:||...||..|.|:.|:::..:::::|:||...:...:.:|.:.|:..|..:..|.:..:
  Rat     4 DEILHHVGDRGRFQIWMIVVLNILSMVSSLHDVIENFTAAIPAHHCSVNLLDTSRSEISMAMNLT 68

  Fly    66 -------CLP--------------------LNRNISTPNT-------C---YSYNYELYMGYQSF 93
                   .:|                    ::.||||.|:       |   ::|::.::.  .:.
  Rat    69 TEAMMKVSIPMGPNQKPEQCRRFRHPQWQFIDSNISTSNSTELETEPCLDGWTYDHSVFT--STI 131

  Fly    94 PSEMDWVCADAWKLTLGQSMFFVGSVVGSMVLGYLADVVGRLPILIVANLIAMTGNLLTIWSTNV 158
            .:|.|.||.........|:....|..|.:...|.::|..||.|:|:..:|..........:..|.
  Rat   132 VTEWDLVCDFQSFKYYAQATSLAGHFVAAPFCGIISDRFGRKPLLMYCSLAYGILGTCCAFVPNF 196

  Fly   159 TLFCMFRMISGIATDSNFVMMYILVMEYMRPSVRTLGLSICI-GFFYCLGSMAAPWIAVLMRSWR 222
            :|:|:.|.:|..:..:..:...|||:|  ..||:.....|.: |.|...|......:|.::..|.
  Rat   197 SLYCVLRFLSSASASTVGMNCLILVLE--ETSVQWHATVIVLSGLFSSTGLAGLGGLAYVLSDWH 259

  Fly   223 GFLLTTSLPLLVVPFFYLIVPESIQWLISKQKYDSAVVCLKRVAKING-RHVEESAYAE----FI 282
            ...||::||..:....:..||||.:||:...|.|.|:..|:|:|.||| :.:.::...|    .:
  Rat   260 LIQLTSALPYFIFFILFCWVPESARWLMITGKTDQALKELQRIASINGKKDIAQNLTTEDLRSKV 324

  Fly   283 EECKCSQQNQKASPHLLDLFQTPRLRRHTLILFFKSMVITLCYDAV-----------SRNVQGLG 336
            :|..||.....:   :.|:...|.:|:           |.|||.:|           ..:|..||
  Rat   325 KEDVCSTVKHFS---IKDIIINPMIRK-----------IVLCYSSVLFAELFSIFGLLLDVHMLG 375

  Fly   337 ISPFVMFSLSATAILPACLLIIALQDRIGRKAMASASLLLSGIFISVTGGIIFAASASDKTTTLL 401
            .:.||...|.....:|:..|...:...:.|:.:.:..|..:|..|::|   :|   .|:....|.
  Rat   376 KNIFVTQILLGVIDIPSKSLTYFILRNVRRRPLIAFLLFATGGCITIT---MF---LSEDMYVLR 434

  Fly   402 VSLSVVGR--FGVTVAYNSGAQYATELIPTCVRG--QGVAAVHVAGYAFTFFSAYILFTRSVFSP 462
            :::.::|:  |...::.|:.  |..||.|..:|.  .|: .:.||..| :..||..|.||..|..
  Rat   435 LAIFILGKGCFAAFISINTA--YCNELSPVPLRSTLNGI-YISVARLA-SVLSALTLVTRKYFVL 495

  Fly   463 LPEIILGVLSLLGACLCLLLPETLHRTLPTSLEDGENFGKNDRWYTFSFLEGRTQSAATLDTQN 526
            ||.|..|||.::.......||||.:..:..:::|.|   |.:|..:.:..|...|.  .|:|.|
  Rat   496 LPMIFCGVLPIVATINIYFLPETFNHPITDTIKDME---KRNRLMSKNISEKEGQD--FLETTN 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7342	NP_001247196.1	2A0119	12..491	CDD:273328	126/540 (23%)
CG7342	NP_001247196.1	MFS	93..>243	CDD:119392	35/150 (23%)
Slc22a22	NP_001013969.1	2A0119	11..526	CDD:273328	126/542 (23%)
Slc22a22	NP_001013969.1	MFS	127..516	CDD:119392	102/416 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347419
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.030