Protein Alignment Dys and ACTN1

DIOPT Version :10

• Sequence 1: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Sequence 2: NP_001410941.1
• Gene: ACTN1 / 87
• HGNCID: 163
• Length: 935
• Species: Homo sapiens
• Alignment Length: 1049
• Identity: 227/1049 - (21%)
• Similarity: 366/1049 - (34%)
• Gaps: 382/1049 - (36%)

  Fly     1 MEP------GILID---ERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQ 56
            |:|      .:|:|   |:|  |:||||.|.||||.... |.::::..|.|||.:|:.||..::.
Human    13 MQPEEDWDRDLLLDPAWEKQ--QRKTFTAWCNSHLRKAG-TQIENIEEDFRDGLKLMLLLEVISG 74

  Fly    57 TNL-KPEKGRMRVHHINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHL 120
            ..| |||:|:||||.|:|:||.:..|...|||||:|.:::||.||.|:|||:||.|.|.|..|.:
Human    75 ERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDI 139

  Fly   121 VKSHSSNGVEKSLLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVEELNLQAALQQ-HAL 183
              |......::.||.|.::.|.|: .:.:.:|..||.||..|..::..|..||.....|:: ..|
Human   140 --SVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPL 202

  Fly   184 KRLHLAFDLAHRHFKIEKLLDAED-VHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQ 247
            ..|:.|||:|.::..|.|:||||| |.|.:||.|:|..||...|||.
Human   203 TNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAF------------------ 249

  Fly   248 DPGRVPCTSITDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGY 312
                                                    ||..|.      .||.|...:
Human   250 ----------------------------------------SGAQKA------ETAANRICK---- 264

  Fly   313 QSALEAVLTLLLEDEQLLSQNLPDPQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSNLINE 377
                  ||.:..|:|||:.                           ::::...:.||
Human   265 ------VLAVNQENEQLME---------------------------DYEKLASDLLE-------- 288

  Fly   378 SQKAGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQLRQFLTSVED 442
                          .:|:.:..|..|.....:.|:              :||||..|.:
Human   289 --------------WIRRTIPWLENRVPENTMHAM--------------QQKLEDFRDY------ 319

  Fly   443 RISHMSDIGPTLEEAEKQLLEAQ----KLKADLSEQQELVDSLSSMVVIVNDTSGNFNDLE---- 499
            |..|..   |.::  ||..||..    :.|..||.:...:.|...||..:|:..|....:|
Human   320 RRLHKP---PKVQ--EKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYE 379

  Fly   500 ----------DRLSALGERWSHVVK----WSDLRKEKLQQ----------YKCISRWLDAREQDL 540
                      :||..|.|::.....    |:|.::..|:|          .|.:.:..:|.|.||
Human   380 EWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDL 444

  Fly   541 KLMESRDVTDVGGITQRINELNY---------CAKDLLELQRYLIDLRQMVAATLQDGDDKGERV 596
            ...:.| |..:..|.|.:|||:|         |.|        :.|....:.|..|...:
Human   445 AAHQDR-VEQIAAIAQELNELDYYDSPSVNARCQK--------ICDQWDNLGALTQKRRE----- 495

  Fly   597 LIQLESYEDRLDALKQIVEVQTVRIETKGFNFGRDRASYDDSRVVRPEGWVDYQMIIRFGEDDSQ 661
              .||..|..|:.:.|:                                :::|
Human   496 --ALERTEKLLETIDQL--------------------------------YLEY------------ 514

  Fly   662 EDDDEHDLASKKRKLRNADNFNALENHIMEHFGYVQEVEQKLQQLQRQSLRQQCELLKELQAENS 726
                          .:.|..||             ..:|..::.||...:....|.::.|...:.
Human   515 --------------AKRAAPFN-------------NWMEGAMEDLQDTFIVHTIEEIQGLTTAHE 552

  Fly   727 RRCGTLPELKKLYEVCELEDPSRNLLLE-ETHIKQLEQRYANLSQKLSSQQSESHTLLAKEKYYN 790
            :...|||:          .|..|..:|. ...:.::.|.|              |..:|....|.
Human   553 QFKATLPD----------ADKERLAILGIHNEVSKIVQTY--------------HVNMAGTNPYT 593

  Fly   791 SLTGFKLVLADSRDWYKQHAGSASGNELEQRLSHMESLASEISEAKT---ATEELDDNLIEWKQD 852
            ::|                     ..|:..:..|:..|.....:|.|   |.::.::.|   ::.
Human   594 TIT---------------------PQEINGKWDHVRQLVPRRDQALTEEHARQQHNERL---RKQ 634

  Fly   853 FGL---FYDSW--HDMKQALQALIQQRGGESLSRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQHF 912
            ||.   ....|  ..|::..:..|:..|  :|..||..::.:...:.|.|.::..|    |..|
Human   635 FGAQANVIGPWIQTKMEEIGRISIEMHG--TLEDQLSHLRQYEKSIVNYKPKIDQL----EGDH- 692

  Fly   913 LNQLLDEMESLRLTYDNIPKHLIGEELQTAWNRLPEQLNERVIKQTTAIEN-------------- 963
              ||:.|    .|.:||...:...|.::..|    |||...:.:....:||
Human   693 --QLIQE----ALIFDNKHTNYTMEHIRVGW----EQLLTTIARTINEVENQILTRDAKGISQEQ 747

  Fly   964 LNHFAAEYN 972
            :|.|.|.:|
Human   748 MNEFRASFN 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH_DMD-like_rpt1	12..118	CDD:409035	51/106 (48%)
		CH_SF	129..229	CDD:469584	38/102 (37%)
		SPEC	312..525	CDD:238103	40/234 (17%)
		PRK03918	<716..1238	CDD:235175	52/280 (19%)
		SMC_prok_B	<995..1279	CDD:274008
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:413338
		SPEC	2369..2576	CDD:238103
		SPEC	2477..2714	CDD:238103
		WW	2852..2882	CDD:238122
		EFh_DMD_like	2919..3085	CDD:320000
		EF-hand-like motif	2919..2958	CDD:320000
		EF-hand-like motif	2961..2995	CDD:320000
		EF-hand-like motif	3001..3037	CDD:320000
		EF-hand-like motif	3050..3085	CDD:320000
		ZZ_dystrophin	3110..3158	CDD:239074
ACTN1	NP_001410941.1	CH_ACTN_rpt1	28..132	CDD:409063	51/106 (48%)
		CH_ACTN_rpt2	136..250	CDD:409065	41/173 (24%)
		SPEC	277..498	CDD:238103	53/310 (17%)
		SPEC	395..622	CDD:238103	55/358 (15%)
		Spectrin	634..733	CDD:395348	25/115 (22%)
		EFh	750..817	CDD:238008	3/7 (43%)
		EFhand_Ca_insen	822..931	CDD:430177