Protein Alignment Dys and ACTN4

DIOPT Version :10

• Sequence 1: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Sequence 2: NP_001427225.1
• Gene: ACTN4 / 81
• HGNCID: 166
• Length: 933
• Species: Homo sapiens
• Alignment Length: 929
• Identity: 213/929 - (22%)
• Similarity: 372/929 - (40%)
• Gaps: 243/929 - (26%)

  Fly     5 ILID---ERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGR 65
            :|:|   |:|  |:||||.|.||||.... |.::::..|.|||.:|:.||..::...| |||:|:
Human    42 LLLDPAWEKQ--QRKTFTAWCNSHLRKAG-TQIENIDEDFRDGLKLMLLLEVISGERLPKPERGK 103

  Fly    66 MRVHHINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGVE 130
            ||||.|||:||.:..|...|||||:|.:::||.||||:|||:||.|.|.|..|.:  |......:
Human   104 MRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDI--SVEETSAK 166

  Fly   131 KSLLAWARQYTEPH-GLQLNDFSSSWSDGRAFLMILDAHVEELNLQAALQQHALKR------LHL 188
            :.||.|.::.|.|: .:.:.:|..||.||.||..::..|..||     ::...|::      |:.
Human   167 EGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPEL-----IEYDKLRKDDPVTNLNN 226

  Fly   189 AFDLAHRHFKIEKLLDAED-VHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRV 252
            ||::|.::..|.|:||||| |:|.:||.|:|..||...|||....:..:
Human   227 AFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAE---------------- 275

  Fly   253 PCTSITDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALE 317
              |:...:.:|...|.:..                      |.|             ..|:....
Human   276 --TAANRICKVLAVNQENE----------------------HLM-------------EDYEKLAS 303

  Fly   318 AVLTLL------LEDE------QLLSQNLPDPQDFQTA--------KLQFHENESFM---LKLTE 359
            .:|..:      |||.      |.:.|.|.|.:|::..        |.|...|.:.:   |:|:.
Human   304 DLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSN 368

  Fly   360 HQEYV---GEALEEGSNLINESQKAGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMR 421
            ...::   |:.:.:.:|.....::|..|..:...||:|             ||..||       .
Human   369 RPAFMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIR-------------RLERLD-------H 413

  Fly   422 LAEFQKQKLEQLRQFLTSVEDRISHMSDIGPTLEEAEKQLLEAQKLKADLSEQQELVDSLSSMVV 486
            |||..:||......:....|..:.|......||.:.:..:.:.:..::||:..|:.|:.::::..
Human   414 LAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQ 478

  Fly   487 IVND----TSGNFNDLEDRLSALGERWSHVVKWSDLRKEKLQ----QYKCI-------------- 529
            .:|:    .|.|.|   .|...:.::|..:...:..|:|.|:    |.:.|
Human   479 ELNELDYYDSHNVN---TRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPF 540

  Fly   530 SRWLDAREQDLKLMESRDVTDVGGITQRINELNYCAKDLLELQRYLIDLRQMVAATLQDGDDKGE 594
            :.|:::..:||:.|         .|...|.|:           ..||.......:||.|.|.:.|
Human   541 NNWMESAMEDLQDM---------FIVHTIEEI-----------EGLISAHDQFKSTLPDADRERE 585

  Fly   595 RVL-IQLESYEDRLDALKQIVEVQTVRIETKGFNFGRDRASYDDSRVVRPEGWVDYQMII----- 653
            .:| |..|:        ::|.|...:::.      |.:..:....:::..: |...|.::
Human   586 AILAIHKEA--------QRIAESNHIKLS------GSNPYTTVTPQIINSK-WEKVQQLVPKRDH 635

  Fly   654 RFGEDDSQEDDDEHDLASKKRKLRN--ADNFNALENHI---MEHFGYVQ-----EVEQKLQQLQR 708
            ...|:.|::..:||        ||.  |...|.:...|   ||..|.:.     .:|.:|..|::
Human   636 ALLEEQSKQQSNEH--------LRRQFASQANVVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQ 692

  Fly   709 QS------------LRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLLLEETHIK-Q 760
            ..            |.||.:|::                    |....::...|..:|  ||: .
Human   693 YERSIVDYKPNLDLLEQQHQLIQ--------------------EALIFDNKHTNYTME--HIRVG 735

  Fly   761 LEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSRDWYKQHAGSASGNELEQRLSHM 825
            .||....:::.::..:::..|..||......:..|:   |....:.|.|.|:....|.:..|..:
Human   736 WEQLLTTIARTINEVENQILTRDAKGISQEQMQEFR---ASFNHFDKDHGGALGPEEFKACLISL 797

  Fly   826 ESLASEISEAKTATEELDD 844
            ........:.:|.:.:.||
Human   798 GYDVENDRQKQTGSMDSDD 816

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH_DMD-like_rpt1	12..118	CDD:409035	53/106 (50%)
		CH_SF	129..229	CDD:469584	37/107 (35%)
		SPEC	312..525	CDD:238103	48/246 (20%)
		PRK03918	<716..1238	CDD:235175	21/130 (16%)
		SMC_prok_B	<995..1279	CDD:274008
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:413338
		SPEC	2369..2576	CDD:238103
		SPEC	2477..2714	CDD:238103
		WW	2852..2882	CDD:238122
		EFh_DMD_like	2919..3085	CDD:320000
		EF-hand-like motif	2919..2958	CDD:320000
		EF-hand-like motif	2961..2995	CDD:320000
		EF-hand-like motif	3001..3037	CDD:320000
		EF-hand-like motif	3050..3085	CDD:320000
		ZZ_dystrophin	3110..3158	CDD:239074
ACTN4	NP_001427225.1	None