DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dys and UTRN

DIOPT Version :10

Sequence 1:NP_001036722.1 Gene:Dys / 42327 FlyBaseID:FBgn0260003 Length:3598 Species:Drosophila melanogaster
Sequence 2:NP_009055.2 Gene:UTRN / 7402 HGNCID:12635 Length:3433 Species:Homo sapiens


Alignment Length:3735 Identity:1088/3735 - (29%)
Similarity:1755/3735 - (46%) Gaps:653/3735 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 DERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNLKPEKGRMRVHHIN 72
            ||...:||||||||||:....:...|:.|:|.||:||.:||.||..||.|:|..|:|..|||.:|
Human    27 DEHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTSLPKERGSTRVHALN 91

  Fly    73 NLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSN----GVEKSL 133
            |:|:|:..:.|:.|:||||...|||.||.||||||:|.|.|.:..:.::|...|:    ..||.|
Human    92 NVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKDVMKDVMSDLQQTNSEKIL 156

  Fly   134 LAWARQYTEPHGLQLN--DFSSSWSDGRAFLMILDAHVEEL-NLQAALQQHALKRLHLAFDLAHR 195
            |:|.||.|.|:. |:|  :|::||:||.||..:|..|..:| :....::...::||..||..|..
Human   157 LSWVRQTTRPYS-QVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVVKMSPIERLEHAFSKAQT 220

  Fly   196 HFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSITDL 260
            :..||||||.|||....||.|||.||:..|:..:                   |.:|...:|.::
Human   221 YLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVL-------------------PQQVTIDAIREV 266

  Fly   261 DEVP----LDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALEAVLT 321
            :.:|    .:.::.::.:   .|....|:..|...:|.     ||.|...:::..||.|||.|||
Human   267 ETLPRKYKKECEEEAINI---QSTAPEEEHESPRAETP-----STVTEVDMDLDSYQIALEEVLT 323

  Fly   322 LLLEDEQLLSQNLPDPQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSNLINESQKAGAGLS 386
            .||..|....:......|.:..|.||..:|:||::||.||..||..|:.|:.||.:..     ||
Human   324 WLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGT-----LS 383

  Fly   387 QEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQLRQFLTSVEDRISHMS--D 449
            .|::.|:::||.|||.|||.||:.::|.|:::...|.|.||::|:||..:||..|:||..|.  .
Human   384 DEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCP 448

  Fly   450 IGPTLEEAEKQLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSGNFND--LEDRLSALGERWSHV 512
            :...::..:|.|.|.:.|::||..:|..|:||:.|||||::.||....  |||:|..|||||:.|
Human   449 LDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAV 513

  Fly   513 VKWSDLRKEKLQQY----------KCISR-WLDAREQDLKLMESRDVTDVGGITQRINELNYCAK 566
            .:|::.|..:||:.          :|:.: ||..:|:.|..:::.:..|...::..:..|....:
Human   514 CRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKE 578

  Fly   567 DLLELQRYLIDLRQMV---AATLQDGDDKGERVLIQLESYEDRLDALKQIVEVQTVRIETKGFNF 628
            | :|::|..:|....:   ...|.|.....:::....|....|.|:|.|.:|..:.::.......
Human   579 D-MEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKL 642

  Fly   629 GRDRASYDD-SRVVRPEGWVDYQMIIRFGEDD------SQEDDDEHDLASKKRKLRNADNFNALE 686
            |..:....| ...||    |..|.|.:..:.:      .::.....|:.:||:       |:|:.
Human   643 GMSQIPQKDLLETVR----VREQAITKKSKQELPPPPPPKKRQIHVDIEAKKK-------FDAIS 696

  Fly   687 ----NHIMEHFGYVQEVEQKLQQLQRQSLRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDP 747
                |.|::....:|..|.| :.::.|...:..:.||.|:.|...|.....||.:..::...:..
Human   697 AELLNWILKWKTAIQTTEIK-EYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMG 760

  Fly   748 SRNLLLEETH--IKQLEQRYANLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSRDWYKQHA 810
            ...|..||..  ::::...:.|:||.|...:.:.........|:..|...:.|:....:|.|..:
Human   761 KEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTS 825

  Fly   811 GSASGNE--------LEQRLSHMESLASEISEAKTATEELDDNLIEWKQDF---GLFYDSWHDMK 864
            .|.|..:        .::.|:::..|..:|..|:.:...|...  ....||   |  :||:....
Human   826 ISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQ--PSAPDFVQRG--FDSFLGRY 886

  Fly   865 QALQALIQQR-----------GGESLSRQLKQIQDFVTKVSNQKVRVS-NL-------------- 903
            ||:|..::.|           .|.:....||.::| |...|..|.:|| |:              
Human   887 QAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKD-VLNDSENKAQVSLNVLNDLAKVEKALQEK 950

  Fly   904 ----EVMQEQQHFLNQLLDEMESLRLTYDNIPKHLIGEE---LQTAWNRLPEQLNERVIKQTTAI 961
                |:::.|:..|::|.:|.::|........:.|..:|   :|..||:|...:::.:.......
Human   951 KTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIA 1015

  Fly   962 ENLNHFAAEYNAIIAMLRSAAD-----SKLNGSDGASSQDLRKL-----EIDVI--SARNFSEI- 1013
            ..|..|.|:...|...:....|     ....|.|....:.|.:.     ||:.|  |.:|..|| 
Human  1016 LTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIE 1080

  Fly  1014 --LIKEAEPAQKESLQSQIRALNTLYDQVEQVHREKKEQQTVL---QSHIDLIQLRLKETDQWLT 1073
              |........|..:|:::....|   |:|::.:|...|::.|   |.....::..|.|..:|:|
Human  1081 TNLRSGPVAGIKTWVQTRLGDYQT---QLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMT 1142

  Fly  1074 ---------DLESNTP---KSGISDIVNSNE-LFQSKSRFQTLKETCERETTQFRDLNERGGELL 1125
                     |.|..:|   :|.:.::..:.| :.|.:.|.:.||:..:....:   :...|.||.
Human  1143 QAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAK---VPSGGQELT 1204

  Fly  1126 LQMDELQDQDRESRYGSLAKQFTRINARWTEVTELVYAKTALLEHISTQLGEFKKFMVSETGYLD 1190
            .:::.:.:     .|..|..:              :..|...||.:.:...|...::..||.:|:
Human  1205 SELNVVLE-----NYQLLCNR--------------IRGKCHTLEEVWSCWIELLHYLDLETTWLN 1250

  Fly  1191 KLENKIRNTPENAADAEEIMEELDDLENVLRSHSEEWLDKIQEIGNELIDNEFMADSIRRDIDET 1255
            .||.::::|.......:.:.|.|:.||:||| |..:...:|:|:|..|||...:.|.|...::..
Human  1251 TLEERMKSTEVLPEKTDAVNEALESLESVLR-HPADNRTQIRELGQTLIDGGILDDIISEKLEAF 1314

  Fly  1256 VQRWTQLQQQAKKRTELLEQKVSEAEQSEKCIVQFEKWLTRVDDILSDHLDNDVTIVDQPEEFQR 1320
            ..|:..|...|:.:...||:::....::::.:...::.|..:|..|:.:|.:.:.....|:|.|:
Human  1315 NSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQK 1379

  Fly  1321 LAHEFVANEKNFKEI------SELIDEHTRNGKVGA-ANRLQEQLNLMEVRFKYCQAKLSKCTAI 1378
            :..|..|:|...:|:      ..|....:|..:.|: .:.||.:|..:..:|:..|...      
Human  1380 IQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPA------ 1438

  Fly  1379 QHSYESRLNRAYTDLRNVERSTEVVDVASAGPNTVQTQYQKCLQIYRTLSEIKSEIESTIKTGRR 1443
              ::|.|:......|..|:....|:||....|:.:||...||:::|:||||:|.|:|:.|||||.
Human  1439 --NFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRH 1501

  Fly  1444 VCEDRYTKSPKQLSQRIDALKHLYNTLGENVTQSKATLERLLTLARQ-------LEECFDSAD-N 1500
            :.:.:.|.:||.:.:::.:||.|||.||..||:.|..|||...|||:       |.|...:.: .
Human  1502 IVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETE 1566

  Fly  1501 LIRRFESPQEVHDRNSILLEFEDVLRRCEDHYNEYNKSCDQSCMVETRQRIDGLKATYHKLTSAD 1565
            |:::..|...:.|.::.:...::||:..|                  :::.|             
Human  1567 LVQKSTSEGLLGDLDTEISWAKNVLKDLE------------------KRKAD------------- 1600

  Fly  1566 IIKRLTEMKTTLQNLDNISLETLRAMEHDLKEINVPSNPEIEKLQQQVIAIVVDVLKTRFNEATT 1630
             :..:||....||||...|...|   |..|..:|..        ..:|.....|...|..|....
Human  1601 -LNTITESSAALQNLIEGSEPIL---EERLCVLNAG--------WSRVRTWTEDWCNTLMNHQNQ 1653

  Fly  1631 LAARNTSSPDNDDTEIVVVSDTVRQRRARTPQSGESPSSAH-------TSSSESPTKGVENSPGA 1688
            |        :..|..:..:|..:.|..|...:..:.|:|..       .|..:.....|||    
Human  1654 L--------EIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVEN---- 1706

  Fly  1689 VGDQVM----------PDLLPPQTFRLAESSTLFSQISLNPQKVTNTPPPKPAKTKRKAPSSPAQ 1743
            |.||.:          .:|:.|   :|||.:..|.::|   |.:.:        .|......|..
Human  1707 VRDQALILMNARGSSSRELVEP---KLAELNRNFEKVS---QHIKS--------AKLLIAQEPLY 1757

  Fly  1744 VVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVNILESVEPFVPEYVETVQIVDLSEDSDSSVRVD 1808
            ...:..:..:.   .|...|||..:.:|       |::..||.:::|       |.|.|..:   
Human  1758 QCLVTTETFET---GVPFSDLEKLENDI-------ENMLKFVEKHLE-------SSDEDEKM--- 1802

  Fly  1809 SQGKEMRRSKSKHSLNETPLPKVSDNDEDSAEQEEDLLRPSAENTSTPFLRVEKRRISFDEKRKR 1873
                                      ||:|| |.|::|:...|....|.         .|.|:::
Human  1803 --------------------------DEESA-QIEEVLQRGEEMLHQPM---------EDNKKEK 1831

  Fly  1874 VANERDILRDSEEEEPKTPDTPRAAQVSKPKRWRQLQPEMDALEPESPGRDSFYSPDKESGFDAE 1938
            :..:..:|.               .:.:|.|.....|.:|..|  .|..|.|....|.....: :
Human  1832 IRLQLLLLH---------------TRYNKIKAIPIQQRKMGQL--ASGIRSSLLPTDYLVEIN-K 1878

  Fly  1939 PLVFSDDEDIPRFSLEMTSTIDSDSDTSRIMTPSTKNPNPFLSKVLESLSSPVDDSNVTLKSPIS 2003
            .|:..||.::.....|:.:.|..|..   ....|.||....|.|:.|.:            :.|.
Human  1879 ILLCMDDVELSLNVPELNTAIYEDFS---FQEDSLKNIKDQLDKLGEQI------------AVIH 1928

  Fly  2004 EEQPQNL-----------------------------DDRVREFDK-------------------- 2019
            |:||..:                             .||...||:                    
Human  1929 EKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWIT 1993

  Fly  2020 QAKQMIY-------KLKLTKAKIEQCHESEAEDLRLLIA---PDAATLISQGDSLVLETHGRQGS 2074
            :|::::.       .|.|.||:|.|      ::|.:.|:   |..|.|...||.:|.:.....||
Human  1994 EAEELLVDTCAPGGSLDLEKARIHQ------QELEVGISSHQPSFAALNRTGDGIVQKLSQADGS 2052

  Fly  2075 -----ISRLVMRTQIILREQFREVQQARSKTSGSGAPAPPLDSVNIEELVTKGLRRINVLI---- 2130
                 ::.|..|...|:    .||:..:.:..|.            .:.|.|...:::.:|    
Human  2053 FLKEKLAGLNQRWDAIV----AEVKDRQPRLKGE------------SKQVMKYRHQLDEIICWLT 2101

  Fly  2131 --EKTVDLKSSTDLEKRMEDINERHDDLQVIVSAI------------GKNAQMPKVTPL------ 2175
              |..:..:|:|:|.:.::::.:...:::|....:            .|:..:|:...:      
Human  2102 KAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLRT 2166

  Fly  2176 -------MMNEIEKTKNNLIAHADSIELSLTELRNGPRISNGKERPDASSAATMSCRSEYNNEPS 2233
                   :..|:..|....|....|:  |.|.:...|   |.::....|||:.:..:|...:|.|
Human  2167 VNMTWNKICREVPTTLKECIQEPSSV--SQTRIAAHP---NVQKVVLVSSASDIPVQSHRTSEIS 2226

  Fly  2234 GTGALAGSFDKSVLQISDWLTWEQNMIKIQSVLVDDGDAVRLAIEKQEKVLRELKMKKPQLNELV 2298
                :....||::.:::|||.....|:|...|.|.|.:.:...:.:.:....:|:.:.|||:.:.
Human  2227 ----IPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVF 2287

  Fly  2299 HTAEVLKGDVKRQQLQEKELKQFSLAPHCSADLDYMRCCL--KVTRLREHWDETSQCVLQRAAQL 2361
            ..|:.||....                  |:|   ||..:  |:.|::..||.|...|..|..||
Human  2288 TLAQNLKNKAS------------------SSD---MRTAITEKLERVKNQWDGTQHGVELRQQQL 2331

  Fly  2362 KNMLSDSQRFEAKRLELEKWLARME------QRAERMGTIATTADILEAQQKEQKSFHAELHQNK 2420
            ::|:.||.:::..|.|.|:.:.:.|      |:|.|        |.|..|..:.:....||....
Human  2332 EDMIIDSLQWDDHREETEELMRKYEARLYILQQARR--------DPLTKQISDNQILLQELGPGD 2388

  Fly  2421 QHFDIFNELTQKLIAVYPNDDTTRIKKMTEVINQRYANLNSGVINRGKQLHAAVHSLQSFDRAMD 2485
            .....|:.:.|||:..|.:|||..:|:.||.:...:.||...:.:|...|.|...::|:..|.::
Human  2389 GIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLE 2453

  Fly  2486 QFLAFLSETETLC---------ENA--ESDIERN-PLMFKDLQSEIETHRVVYDRLDGTGRKLLG 2538
            .||.::.|.||..         |||  :|.:.|. ....:|:|:||:.|..::..:||..:|::.
Human  2454 NFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVK 2518

  Fly  2539 SLTSQEDAVMLQRRLDEMNQRWNNLKSKSIAIRNRLESNSEHWNALLLSLRELTEWVIRKDTELS 2603
            :|.:.|:|.|||.|||:||||||:||:||.:||..||:::|.||.||:||.||.:|:..||.||.
Human  2519 ALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELK 2583

  Fly  2604 TLGLGPVRGDAVSLQKQLDDHKAFRRQLEDKRPIVESNLTSGRQYIANEAAVSDTSDTEANHDSD 2668
            .  ..|:.||..:||.|.|..||.||:|::|...|.:.:...|.::|:: .:....:...|..|.
Human  2584 K--QMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQ-PIEAPEEPRRNLQSK 2645

  Fly  2669 SRYMSAEEQSRELTRSIRREVGKLSEQWNNLIDRSDNWKHRLDEYMTKMRQFQKILEDLSSRVAL 2733
            :. ::.||:::::.:::|::..::.|:|.:|...:.||:.::|:.:.|:|..|..::||.:.:..
Human  2646 TE-LTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKE 2709

  Fly  2734 AEQTKTSWLPPSS--VGEANEQMQQLQRLRDKMTTASALLDDCNEQQSFFTANQVLVPTPCLSK- 2795
            ||..:..|.|...  :....:.::::...|:::...:..:...|:..|..:... |.|:..:|: 
Human  2710 AESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLD-LHPSLKMSRQ 2773

  Fly  2796 LEDLNTRMKLLQIAMDERQKVLCQAGAQQTHENGDDGRTTSNSGTIGPLPN--LGQSVKPPWERA 2858
            |:|||.|.||||:::|:|.|.|     |:.|.:            .||...  |..||:.||:|:
Human  2774 LDDLNMRWKLLQVSVDDRLKQL-----QEAHRD------------FGPSSQHFLSTSVQLPWQRS 2821

  Fly  2859 TTAANVPYYIDHERETTHWDHPEMIELMKGLADLNEIRFSAYRTAMKLRSVQKRLALDRISMSTA 2923
            .:...|||||:|:.:||.||||:|.||.:.|||||.:||||||||:|:|.:||.|.||.:.:||.
Human  2822 ISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLLELSTT 2886

  Fly  2924 CESFDRHGLRAQNDKLIDIPDMTTVLHSLYVTI-----DKIDLTLMLDLAINWILNVYDSQRTGQ 2983
            .|.|.:|.|. |||:|:.:||:...|.:.|..:     |.:::.|.:|:.:||:|||||:.|||:
Human  2887 NEIFKQHKLN-QNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLNVYDTGRTGK 2950

  Fly  2984 IRVLSFKVGLVLLCKGHLEEKYRYLFRLVADTDRRADQRRLGLLLHDCIQVPRQLGEVAAFGGSN 3048
            |||.|.|:||:.|.||.|||||||||:.||......|||:|||||||.||:||||||||||||||
Human  2951 IRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQIPRQLGEVAAFGGSN 3015

  Fly  3049 IEPSVRSCLEQAGISQEAIDGNQDISIELQHFLGWLQHEPQSLVWLPVLHRLAAAEAAKHQAKCN 3113
            ||||||||.:|         .|....|.::.|:.|:..||||:||||||||:||||.||||||||
Human  3016 IEPSVRSCFQQ---------NNNKPEISVKEFIDWMHLEPQSMVWLPVLHRVAAAETAKHQAKCN 3071

  Fly  3114 ICKEYPIVGFRYRCLKCFNFDMCQKCFFFGRNAKNHKLTHPMHEYCTTTTSTEDVRDFTRALKNK 3178
            ||||.||||||||.||.||:|:||.|||.||.||.|||.:||.|||..|||.|||||||:.||||
Human  3072 ICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPTTSGEDVRDFTKVLKNK 3136

  Fly  3179 FKSRKYFKKHPRVGYLPVQSVLEGDALESPAP---------SPQHTTHQLQNDMHSRLEMYASRL 3234
            |:|:|||.||||:||||||:|||||.||:|..         .|..:.....:|.|||:|.||:||
Human  3137 FRSKKYFAKHPRLGYLPVQTVLEGDNLETPITLISMWPEHYDPSQSPQLFHDDTHSRIEQYATRL 3201

  Fly  3235 AQVEYGG----TGSNSTPDS-DDEHQLIAQYCQALPGTSNGSAPKSPVQVMAAMDAEQREELEAI 3294
            ||:|...    |.|:||..| :|||.||.||||.|.|.|..|.|:||.|::.:::.|:|.|||.|
Human  3202 AQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQILKSVEREERGELERI 3266

  Fly  3295 IRDLEEENANLQAEYQQLCSKEQS-------GMPEDSNGMQHSSSSMTGLSGQGEQGQDMMAEAK 3352
            |.|||||..|||.||:||  |:|.       |.|.:|....|.:|          :..:::||||
Human  3267 IADLEEEQRNLQVEYEQL--KDQHLRRGLPVGSPPESIISPHHTS----------EDSELIAEAK 3319

  Fly  3353 LLRQHKGRLEARMQILEDHNRQLEAQLQRLRQLLDEPNG----GGSSATSSGLPSAPGSALNSKP 3413
            ||||||||||||||||||||:|||:||.||||||::|..    .|.|..:|...||...:|:...
Human  3320 LLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDSRINGVSPWASPQHSALSYSLDPDA 3384

  Fly  3414 NTLQTRSVTASQL-------NTDSPAKMNQ 3436
            :..|........|       :||....|.|
Human  3385 SGPQFHQAAGEDLLAPPHDTSTDLTEVMEQ 3414

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DysNP_001036722.1 CH_DMD-like_rpt1 12..118 CDD:409035 54/105 (51%)
CH_SF 129..229 CDD:469584 43/102 (42%)
SPEC 312..525 CDD:238103 87/216 (40%)
PRK03918 <716..1238 CDD:235175 121/598 (20%)
SMC_prok_B <995..1279 CDD:274008 67/309 (22%)
SPEC 1174..1365 CDD:238103 45/197 (23%)
SPEC 1289..1485 CDD:413338 60/202 (30%)
SPEC 2369..2576 CDD:238103 70/224 (31%)
SPEC 2477..2714 CDD:238103 84/248 (34%)
WW 2852..2882 CDD:238122 15/29 (52%)
EFh_DMD_like 2919..3085 CDD:320000 87/170 (51%)
EF-hand-like motif 2919..2958 CDD:320000 14/43 (33%)
EF-hand-like motif 2961..2995 CDD:320000 19/33 (58%)
EF-hand-like motif 3001..3037 CDD:320000 24/35 (69%)
EF-hand-like motif 3050..3085 CDD:320000 12/34 (35%)
ZZ_dystrophin 3110..3158 CDD:239074 35/47 (74%)
UTRNNP_009055.2 actin-binding domain 1..246 98/219 (45%)
CH_UTRN_rpt1 31..137 CDD:409081 54/105 (51%)
CH_UTRN_rpt2 152..255 CDD:409083 43/122 (35%)
Interaction with SYNM. /evidence=ECO:0000269|PubMed:16777071 268..905 168/666 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 284..303 4/26 (15%)
spectrin-like triple coiled-coil repeat 309..2797 640/2772 (23%)
SPEC 310..528 CDD:238103 88/222 (40%)
SPEC 530..>646 CDD:413338 20/116 (17%)
SPEC 803..1013 CDD:238103 43/214 (20%)
SPEC 910..1123 CDD:238103 45/216 (21%)
Spectrin 6. /evidence=ECO:0000255 910..1012 21/102 (21%)
Spectrin 7. /evidence=ECO:0000255 1019..1121 22/104 (21%)
Spectrin 8. /evidence=ECO:0000255 1128..1229 19/122 (16%)
SPEC 1132..1336 CDD:238103 49/226 (22%)
SPEC 1235..1446 CDD:238103 49/219 (22%)
Spectrin 9. /evidence=ECO:0000255 1236..1333 26/97 (27%)
Spectrin 10. /evidence=ECO:0000255 1335..1436 18/100 (18%)
Interaction with SYNM. /evidence=ECO:0000269|PubMed:16777071 1336..1768 111/508 (22%)
SPEC 1440..1649 CDD:413338 67/251 (27%)
Spectrin 14. /evidence=ECO:0000255 1748..1848 27/170 (16%)
Spectrin 15. /evidence=ECO:0000255 1849..1968 24/136 (18%)
SPEC 1977..2179 CDD:238103 34/223 (15%)
Spectrin 16. /evidence=ECO:0000255 1979..2080 22/110 (20%)
Spectrin 17. /evidence=ECO:0000255 2087..2186 11/98 (11%)
Spectrin 18. /evidence=ECO:0000255 2229..2332 29/123 (24%)
SPEC 2230..2442 CDD:238103 61/240 (25%)
Spectrin 19. /evidence=ECO:0000255 2349..2439 24/97 (25%)
Spectrin 20. /evidence=ECO:0000255 2446..2555 41/108 (38%)
SPEC 2450..2690 CDD:238103 83/243 (34%)
Spectrin 21. /evidence=ECO:0000255 2562..2687 38/128 (30%)
SPEC 2692..>2808 CDD:238103 32/133 (24%)
Spectrin 22. /evidence=ECO:0000255 2694..2796 27/107 (25%)
Interaction with SYNM. /evidence=ECO:0000269|PubMed:16777071 2798..3165 224/388 (58%)
WW domain 2812..2845 17/32 (53%)
WW 2817..2845 CDD:238122 15/27 (56%)
cys-rich domain 2877..3117 145/249 (58%)
EFh_UTRO 2882..3043 CDD:320005 87/170 (51%)
EF-hand-like motif 2882..2921 CDD:320005 14/39 (36%)
EF-hand-like motif 2928..2962 CDD:320005 19/33 (58%)
EF-hand-like motif 2968..3004 CDD:320005 24/35 (69%)
EF-hand-like motif 3017..3043 CDD:320005 12/34 (35%)
ZZ domain 3064..3111 37/46 (80%)
ZZ_dystrophin 3068..3116 CDD:239074 35/47 (74%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 3357..3390 7/32 (22%)

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