Protein Alignment Dys and beta-Spec

DIOPT Version :10

• Sequence 1: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Sequence 2: NP_001259660.1
• Gene: beta-Spec / 32746
• FlyBaseID: FBgn0250788
• Length: 2308
• Species: Drosophila melanogaster
• Alignment Length: 3016
• Identity: 595/3016 - (19%)
• Similarity: 1037/3016 - (34%)
• Gaps: 1036/3016 - (34%)

  Fly     6 LIDERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-KPEKGRMRVH 69
            |.:||:.:||||||||:||||....|. :.||::|:|||..|:.||..|:...| ||.||:||:|
  Fly    44 LAEERESVQKKTFTKWVNSHLCRVNCR-IADLYVDMRDGKHLIKLLEVLSGERLPKPTKGKMRIH 107

  Fly    70 HINNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHL----VKSHSSNGVE 130
            .:.|::|.:..:::..|.|.||.|.|||.|||.|.|||||.|.|.|..|.:    |.:..:...:
  Fly   108 CLENVDKALQFLREQRVHLENIGSHDIVDGNASLNLGLIWTIILRFQIQDITIEEVDNKETKSAK 172

  Fly   131 KSLLAWARQYTEP-HGLQLNDFSSSWSDGRAFLMILDAHVEEL-NLQAALQQHALKRLHLAFDLA 193
            .:||.|.:..|.. |.:.:.:|::||.||.||..|:..|..:| ..:...:.:|:..|:.|||:|
  Fly   173 DALLLWCQMKTAGYHNVNVRNFTTSWRDGLAFNAIIHKHRPDLVQFEKLSKTNAIHNLNNAFDVA 237

  Fly   194 HRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSIT 258
            .....:.||||||||....||.|||..||:..||....::     ||..:|:          .|.
  Fly   238 EDKLGLAKLLDAEDVFVEHPDEKSIITYVVTYYHYFSKLK-----QETVQGK----------RIG 287

  Fly   259 DLDEVPLDNDQT--SLGLYTSDSAGSMEQ--RSSGELKTHSMRPLSTATNASVEISGYQSA---- 315
            .:..:.::||:.  ....:|||....:|.  :|.||.:..:  .|:.......:.|.|::.
  Fly   288 KVVGIAMENDKMVHDYENFTSDLLKWIETTIQSLGEREFEN--SLAGVQGQLAQFSNYRTIEKPP 350

  Fly   316 -------LEAVLTLLLEDEQLLSQNLPDPQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSN 373
                   ||.:|..|                  .:|::.:..:.:
  Fly   351 KFVEKGNLEVLLFTL------------------QSKMRANNQKPY-------------------- 377

  Fly   374 LINESQKAGAGLSQEDQNEVRQQMVLLNERWETLRLRALDVQAKILMRLAEFQKQKLEQL----- 433
                :.|.|..:|.            :|:.||  ||...:.:.::.:|....:::|||||
  Fly   378 ----TPKEGKMISD------------INKAWE--RLEKAEHERELALREELIRQEKLEQLAARFD 424

  Fly   434 -----RQFLTSVEDRISHMSDIGPTLEEAEKQLLEAQKLKADLSEQQELVDSLSSMVVIVNDTSG 493
                 |:...|...|:....:.|..|...|....:.:.::.|:...:|.|.:    ||.|.|
  Fly   425 RKASMRETWLSENQRLVSQDNFGFDLAAVEAAAKKHEAIETDIFAYEERVQA----VVAVCD--- 482

  Fly   494 NFNDLEDRLSALGERWSHVVKWSDLRKEKLQQ-YKCISRWLDAREQDLKLMESRDVTDVGGITQR 557
               :||      .||: |.||...|||:.:.: :..:...|.||...|::...        :.|.
  Fly   483 ---ELE------SERY-HDVKRILLRKDNVMRLWTYLLELLRARRMRLEISLQ--------LQQN 529

  Fly   558 INELNYCAKDLLELQRYLIDLRQMVAATLQDGDDKGERVLIQLESYEDRLDALKQIVEVQTVRIE 622
            ..|:.|...::.|:::.|:.            ||.|:.::    ..||.|
  Fly   530 FQEMLYILDNMEEIKQLLMT------------DDYGKHLM----GVEDLL--------------- 563

  Fly   623 TKGFNFGRDRASYDDSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKRKLRNADNFNALEN 687
                                                             :|..|..|| .|.|..
  Fly   564 -------------------------------------------------QKHSLVEAD-INILGE 578

  Fly   688 HIMEHFGYVQEVEQKLQQLQRQSLRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLL 752
            .:                              ::..:||::  .|.:..:.|:.|:.|
  Fly   579 RV------------------------------KVVVQNSQK--FLSDDPESYKPCDPE------- 604

  Fly   753 LEETHIKQLEQRYA---NLSQKLSSQQSESHTLLAKEKYYNSLTGFKLVLADSRDWYKQHAGSAS 814
            :..:.::|||..||   .|:.:..|:..||..|.  :.|:::        ||..:|.|:.....|
  Fly   605 IIVSRVQQLEDAYAELVRLAVERRSRLEESRKLW--QFYWDT--------ADEENWIKEKEQIVS 659

  Fly   815 GNELEQRLSHMESLASEISEAKTATEELDDNLIEWKQDFGLFYDSWHDMKQALQALIQQRGGESL 879
            .:|:...|:.:..:   :|:.|....|:..                ||
  Fly   660 TDEVGHDLTTVNLM---LSKHKALESEITS----------------HD----------------- 688

  Fly   880 SRQLKQIQDFVTKVSNQKVRVSNLEVMQEQQHFLNQLLDEMESLRLTYDNIPKHLIGEELQTAWN 944
                .|:|: |.||.::.:         .:.||             ..|.|...|  :|:...|:
  Fly   689 ----PQLQN-VAKVGSELI---------TEGHF-------------GADRIKDRL--KEILNKWD 724

  Fly   945 RLPEQLNERVIKQTTAIENLNHFAAE---YNAIIAMLRSAADSKLNGSDGASSQDLRKLEIDVI- 1005
            .|.:....|..:...|:|....||..   .|.::..||..:...: |.|.|:.|.|.|...||.
  Fly   725 HLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDV-GRDEANVQSLLKKHKDVAD 788

  Fly  1006 SARNFSEI---LIKEAE-----PAQKESLQSQIRALNTLYDQVEQVHREKKEQQTVLQSHIDLIQ 1062
            ..:|::|:   |.|:||     .|:|.::..::.|::..|.::.::.:.:|::   |...:.|.:
  Fly   789 ELKNYAEVIDALHKQAESLKLNEAEKANVDKRLEAIDNRYKELTELAKLRKQR---LLDALSLYK 850

  Fly  1063 LRLKETD---QWLTD----LESNTPKSGISDIVNSNELFQSKSRFQTLKETCERETTQFRDLNER 1120
            | :.|.|   ||:.:    |::.||...|.|:    |:.  |.||:...:......::...:|:.
  Fly   851 L-MSEADGVEQWIKEKTKMLDTMTPGKDIEDV----EIM--KHRFEGFDKEMNANASRVAVVNQL 908

  Fly  1121 GGELL----LQMDELQDQDRESRYGSLAKQFTRINARWTEVTELVYAKTALLEHISTQLG----- 1176
            ..:||    ...||:.::.            ..:|..|:.:.|...||   ::.:.:..|
  Fly   909 ARQLLHVEHPNSDEILERQ------------NHLNQEWSTLREKAEAK---MDDLKSAHGVQTFY 958

  Fly  1177 ----------EFKKFMVSETGYLDKLENKI-------RNTPENAADAEEIMEELDDLENVLRS-- 1222
                      |.||.:::||   |.||..:       |.......|...|..:|..||....|
  Fly   959 IECRETISWIEDKKRILTET---DSLEMDLTGVMTLQRRLSGMDRDLAAIQAKLSSLEREANSIE 1020

  Fly  1223 --HSEEWLDKIQEIGNELIDNEFMADSIRRDIDETVQRWTQLQQQAKKRTELLEQKVSEAEQSEK 1285
              |.||                  |..||..|.:....|.||.|..|:|...||: ..:..:..:
  Fly  1021 DEHPEE------------------AKIIRERIAQIELIWEQLTQMLKERDSKLEE-AGDLHRFLR 1066

  Fly  1286 CIVQFEKWLTRVDDILSDHLDNDVTIVDQP---EEFQRLAHEFVANEKNFKEISELIDEHTRNGK 1347
            .:..|:.|||:.        ..||...|.|   .|.::|.::       .:.|.|.||.:|.:.|
  Fly  1067 DLDHFQTWLTKT--------QTDVASEDTPTSLPEAEKLLNQ-------HQSIREEIDNYTEDYK 1116

  Fly  1348 VGAANRLQEQLNLMEVRFKYCQAKLSKCTAIQHSYESRLNRAYTDLRNVERSTEVVDVASAGPNT 1412
                       |:||                   |..||                   .|.|..:
  Fly  1117 -----------NMME-------------------YGERL-------------------TSEGSTS 1132

  Fly  1413 VQTQYQKCLQIYRTLSEIKSEIESTIKTGRRVCEDRYTKSPKQLSQRIDALKHLYNTLGENVTQS 1477
            ...||.                                    .|.:|::|||
  Fly  1133 DDPQYM------------------------------------FLRERLNALK------------- 1148

  Fly  1478 KATLERLLTLARQLEECFDSADNLIRRFESPQEVHDRNSILLEFEDVLRRCEDHYNEYNKSCDQS 1542
                              |..:.|.:.:|:.|       :||                ::|.||
  Fly  1149 ------------------DGWEELHQMWENRQ-------VLL----------------SQSLDQ- 1171

  Fly  1543 CMVETRQRIDGLKATYHKLTSADIIKRLTEMKTTLQNLDNISLETLRAMEHDLKEINVPSNPEIE 1607
                             :|.:.|  .|.||:             .|...||.|.:.:.|.|  :|
  Fly  1172 -----------------QLFNRD--ARQTEV-------------LLSQQEHFLSKDDTPVN--LE 1202

  Fly  1608 KLQQQVIAIVVDVLKTRFNEATTLAARNTSSPDNDD--TEIVVVSDTVRQRRARTPQSGESPSSA 1670
            :.:.|        ||......||:.|       |||  ..::.|:||:.::
  Fly  1203 QAENQ--------LKRHEAFLTTMEA-------NDDKINTLLQVADTLVEK-------------- 1238

  Fly  1671 HTSSSESPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQISLNPQKVTNTPPPKPAKTKR 1735
            ....::...|..||..|...|                          |.|:..:
  Fly  1239 DHFDADKIGKRAENITGRRDD--------------------------NRQRALD----------- 1266

  Fly  1736 KAPSSPAQVVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVNILESVEPFVPEYVETVQIVDLSED 1800
                             |::|:.        .|.::.:.:..||.:..:|.|...|.|
  Fly  1267 -----------------QHEKLK--------NQVKLHEFLQDLEELAEWVQEKYATSQ------- 1299

  Fly  1801 SDSSVRVDSQGKEMRRSKSKHSLNETPLPKVSDNDEDSAEQEEDLLRPSAENTSTPFLRVEKRRI 1865
             |.|.|   ..|.:....::|...|.   :::.|.|...|.|:     ||:..|
  Fly  1300 -DESYR---SAKTIHSKWTRHQAFEA---EIAANKERLFEAEK-----SAQELS----------- 1341

  Fly  1866 SFDEKRKRVANERDILRDSEEEEPKTPDTPRAAQVSKPKRWRQLQPEMDALEPESPGRDSFYSPD 1930
                                :|:|:..|      |.:|| .::|..:.|.||..:
  Fly  1342 --------------------KEKPEFKD------VIEPK-LKELAKQFDDLEVHT---------- 1369

  Fly  1931 KESG---FDA--EPLVFSDDEDIPRFSLEMTSTIDSDSDTSRIMTPSTKNPNPFLSK--VLESLS 1988
            ||.|   |||  |.||....:||..:..::...|.| .||:..:|    :.|..:.|  |:::..
  Fly  1370 KEKGAMLFDANREVLVQQTCDDIDSYITDLEKQIVS-GDTANDLT----SVNILMQKQQVIQTQM 1429

  Fly  1989 S-------PVDDSNVTLKSPISEEQPQNLDDR----VREFDKQAKQMIYKLKLTKAKIEQ---CH 2039
            :       .:|.....|:..:.||:.:.:..:    :..|:|....::.:.|..:.|.|.   |.
  Fly  1430 AVKARQVEEIDKQTEYLQKTVPEEKIEPIVVKKTAVLERFEKIKAPLLERQKALEKKKEAFQFCR 1494

  Fly  2040 ESEAE----DLRLLIA--PD-------AATLISQGDSLVLETHGRQGSISRLVMRTQIILREQFR 2091
            :.|.|    |.:|.:|  ||       ...|..:..||..|....:..|:.:....:.::.|...
  Fly  1495 DVEDEKLWIDEKLPVANSPDYGNSLFNVHVLKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHE 1559

  Fly  2092 EVQQARSKTSGSGAPAPPLDSVNIEELVTKGLRRINVLIEKTVDLKSSTDLEKRMEDINERHDDL 2156
                               |:...|.|::.       |.:|..:||.:  :|.|.:.:.|.....
  Fly  1560 -------------------DAKKFEALISD-------LTQKWQELKDA--IENRRKHLLESEKVQ 1596

  Fly  2157 QVIVSAIGKNAQMPKVTPLMMNE----IEKTKNNLIAHADSIELSLTELRNGPR----ISNGKER 2213
            |....|....:.|.:....||.|    .|.:..||:...:::|.|:.:..|..|    ::.....
  Fly  1597 QYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKHENLEQSVEDYANTIRQLGEVARQFSG 1661

  Fly  2214 PDASSAATMSCR-SEYNNEPSGTGALAGS-------------FDKSVLQISDWLTWEQNMIKIQS 2264
            .|.||...::.: |:.:...:|...|||.             ..:.|..:..|:| ::.::....
  Fly  1662 DDISSGDAVAVKQSQLDKLYAGLKDLAGERRARLNEALQLFMLSREVDDLEQWIT-DREVVAGSQ 1725

  Fly  2265 VLVDDGDAVRLAIEKQEKVLRELKMKKPQLNELVHTAEVLKGDVKRQQLQEKELKQFSLAPHC-- 2327
            .|..|.|.|.|..|:              .||.....|.:.|        |:..|...:|.:.
  Fly  1726 ELGQDFDHVTLLSER--------------FNEFARDTEAVGG--------ERVAKVNGIADNLIQ 1768

  Fly  2328 -----SADLDYMRCCLKVTRLREHWD------ETSQCVLQRAAQLKNMLSDSQRFEAKRLELEKW 2381
                 ||.:...:     ..|.|.|.      ||...:|..:.:|.....|.:....:.||.:..
  Fly  1769 AGHSDSATIAEWK-----DNLNESWQDLLELIETRTQMLAASRELHKFFHDCKDVLGRILEKQHG 1828

  Fly  2382 LARMEQRAERMGTIATTADILEAQQKEQKSFHAELHQNKQHFDIFNELTQKLIAVYPNDDTTRIK 2446
            ::  ::.....|:::|.       |::..:|..:|...........|.:.||...|..|....|.
  Fly  1829 VS--DELGRDAGSVSTL-------QRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKAKEIT 1884

  Fly  2447 KMTEVINQRYANLNSGVINRGKQLHAAVHSLQSFDRAMDQFLAFLSETETLCENAES--DIERNP 2509
            ...:.:...:.||.: :.:..||..|....|..|...:...:.::.:.......:|.  |:....
  Fly  1885 NREQEVLHAWDNLQA-MCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVE 1948

  Fly  2510 LMF---KDLQSEIETHRVVYDRLDGTGRKLLG--------------SLTSQEDAVMLQRRLDEMN 2557
            |:.   :.|::||:|....:......|::||.              :|::..:|::  ||.:|
  Fly  1949 LLMNNHQSLKAEIDTREDNFGACISLGKELLTRNHYASADIKDRLMTLSNSRNALL--RRWEE-- 2009

  Fly  2558 QRWNNLKSKSIAIRNRLESNSEHWNALLLSLRELTE-------WVIRKDTELSTLGLGPVRGDAV 2615
             ||.||:                   |:|.:.:...       |:|.::..|.:..||....:..
  Fly  2010 -RWENLQ-------------------LILEVYQFARDAAVAEAWLIAQEPYLLSSELGHTIDEVE 2054

  Fly  2616 SLQKQLDDHKAFRRQ--LEDKRPIVESNLTS-------GRQYIANEA------------AVS--- 2656
            :|.|:   |:||.:.  .:::|......||:       .||.:|.||            |.|
  Fly  2055 NLIKK---HEAFEKSAAAQEERFSALERLTTFELKEMKRRQELAEEAERQRIKEEQEAKAASEAA 2116

  Fly  2657 ----------DTSDTEANHDSDSRYMSAEEQSRELTRSIRREVG-------------KLSEQWNN 2698
                      |..|..|:||..:...:|.|..|.:  .|:.|.|             ....:|::
  Fly  2117 EQAKREAERRDDVDVGASHDDSAAKDTAVEFERVV--EIQTERGGTPGAGEGHEGYVTRKHEWDS 2179

  Fly  2699 LIDRSDN--WKHRLDE-YMTKMR---QFQKILEDLSSRVALAEQTKTSW-LPPSSVGEANEQMQQ 2756
            ...::.|  |    |: ||....   .|.|..:...|...|..:.:.|: |..:::..|::..::
  Fly  2180 TTKKASNRSW----DKVYMAAKAGRISFYKDQKGYKSNPELTFRGEPSYDLQNAAIEIASDYTKK 2240

  Fly  2757 LQRLRDKMTTASALL----DDCNEQQ 2778
            ...||.|:...:..|    ||....|
  Fly  2241 KHVLRVKLANGALFLLQAHDDTEMSQ 2266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH_DMD-like_rpt1	12..118	CDD:409035	53/106 (50%)
		CH_SF	129..229	CDD:469584	38/101 (38%)
		SPEC	312..525	CDD:238103	43/233 (18%)
		PRK03918	<716..1238	CDD:235175	114/573 (20%)
		SMC_prok_B	<995..1279	CDD:274008	73/329 (22%)
		SPEC	1174..1365	CDD:238103	50/219 (23%)
		SPEC	1289..1485	CDD:413338	31/198 (16%)
		SPEC	2369..2576	CDD:238103	39/225 (17%)
		SPEC	2477..2714	CDD:238103	58/312 (19%)
		WW	2852..2882	CDD:238122
		EFh_DMD_like	2919..3085	CDD:320000
		EF-hand-like motif	2919..2958	CDD:320000
		EF-hand-like motif	2961..2995	CDD:320000
		EF-hand-like motif	3001..3037	CDD:320000
		EF-hand-like motif	3050..3085	CDD:320000
		ZZ_dystrophin	3110..3158	CDD:239074
beta-Spec	NP_001259660.1	CH_SPTB-like_rpt1	36..152	CDD:409095	54/108 (50%)
		CH_SPTB_like_rpt2	169..273	CDD:409097	38/103 (37%)
		Spectrin	298..408	CDD:395348	23/167 (14%)
		SPEC	422..521	CDD:197544	26/115 (23%)
		SPEC	525..740	CDD:238103	60/417 (14%)
		SPEC	639..846	CDD:238103	54/283 (19%)
		SPEC	848..1058	CDD:238103	56/253 (22%)
		SPEC	955..1169	CDD:238103	67/389 (17%)
		SPEC	1170..1380	CDD:238103	70/402 (17%)
		SPEC	1386..1484	CDD:197544	17/102 (17%)
		SPEC	1488..1699	CDD:238103	46/238 (19%)
		SPEC	1594..1806	CDD:238103	45/239 (19%)
		SPEC	1807..2015	CDD:238103	40/222 (18%)
		Spectrin	2018..>2078	CDD:395348	12/62 (19%)
		PH_beta_spectrin	2167..2274	CDD:269975	20/104 (19%)