Protein Alignment Dys and ain1

DIOPT Version :10

• Sequence 1: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Sequence 2: NP_594295.1
• Gene: ain1 / 2542805
• PomBaseID: SPAC15A10.08
• Length: 621
• Species: Schizosaccharomyces pombe
• Alignment Length: 746
• Identity: 182/746 - (24%)
• Similarity: 293/746 - (39%)
• Gaps: 211/746 - (28%)

  Fly    11 QHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNL-----KPEKGRMRVHH 70
            |.:|.:|||||.|:.|.......|.||..||.||..|:.||..:...||     .|   |||||.
pombe     7 QSVQNRTFTKWFNTKLSSRDLPSVFDLRKDLSDGILLIQLLEIIGDENLGRYNRNP---RMRVHR 68

  Fly    71 INNLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKSHSSNGV--EKSL 133
            :.|:||.:..|:..|:.|.||...|||.||.||.|||||.:.|.|.    :...:..|:  ::.|
pombe    69 LENVNKALEYIKSKGMPLTNIGPADIVDGNLKLILGLIWTLILRFT----IADINEEGLTAKEGL 129

  Fly   134 LAWARQYTEPH--GLQLNDFSSSWSDGRAFLMILDAHVEELNLQAALQQHALKR------LHLAF 190
            |.|.::.|..:  .:.:.||:.||::|.||..::..|..:|     |..:.|.:      :.|||
pombe   130 LLWCQRKTANYHPEVDVQDFTRSWTNGLAFCALIHQHRPDL-----LDYNKLDKKNHRANMQLAF 189

  Fly   191 DLAHRHFKIEKLLDAEDV-HTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPC 254
            |:|.:...|.:|::.||| ...:||.:||..||...:||..:
pombe   190 DIAQKSIGIPRLIEVEDVCDVDRPDERSIMTYVAEYFHAFST----------------------- 231

  Fly   255 TSITDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLSTATNASVEISGYQSALEAV 319
                 ||:|             ..:|..:|:.:...:.||.|:            ..|:|.::.:
pombe   232 -----LDKV-------------ETAARRVERFTEVLMSTHDMK------------IDYESRMKRL 266

  Fly   320 LTLLLEDEQL-----LSQNLPDPQDFQTAKLQFHENESFMLKLTEHQEYVGEALEEGSNL--INE 377
            |..:...::.     ...|..|        ::.|.|.....|.||.:|:|.|.::..|.|  |..
pombe   267 LGSIARMQEYWHTVQFENNYTD--------VKSHSNNFAKFKATEKREWVKEKIDLESLLGTIQT 323

  Fly   378 SQKA--------GAGLSQED--------QNEVRQQMVLLN----ERWETLRLRALDVQAKILMRL 422
            :.|.        .|||...|        .:|...|..|:|    |..|::|:...|       |.
pombe   324 NLKTYQLRKYEPPAGLKIVDLERQWKDFLSEEANQSKLINTHMREIKESMRIAFAD-------RA 381

  Fly   423 AEFQKQKLEQLRQFLTSVE----DRISHM----SDIGPTLEEAEKQLLEAQKLKADLSEQQELVD 479
            ..|.|. |..:...:|:::    |::.|:    ..:||              |:.:|:..:.|.|
pombe   382 NSFSKM-LSTISNEITNLQGDWRDQLDHVEFLQEHLGP--------------LEVELASVKVLYD 431

  Fly   480 SLSSMVVIVND-TSGNFNDLEDRLSALGERWSHVVKWSDLRKEKLQQYKCISRWLDAREQDLKLM 543
            :.....:..|| |..::.|||..........::.:|:  |..|.|::.|   |.|..:|.|
pombe   432 NCFQAGIEENDYTMFSYEDLEHEFGITANIIANKIKY--LENELLEREK---RTLSKQELD---- 487

  Fly   544 ESRDVTDVGGIT--------QRINELN----YCAKDLLELQRYLIDLRQMV-----AATLQDGDD 591
                     |||        ::.|.||    |.|...|.|   :.|..:..     ||..::|..
pombe   488 ---------GITKVFRHFEKKKSNMLNEVEFYAALASLGL---VYDTEEGTALFHRAANSEEGVT 540

  Fly   592 KGERVLIQLESYEDRLDALKQIVEVQTVRIETKGFNF-----GRDRASYDD--SRVVRPEGWVDY 649
            ......|.:|..||| |:.:|::           :.|     |:...:.||  ...|||.
pombe   541 YERFTEIVMEELEDR-DSARQVL-----------YAFCDVADGKSYVTSDDLLRSQVRPN----- 588

  Fly   650 QMIIRFGEDDSQEDDDEHDLASKKRKLRNAD 680
              |::|.|.:..:..:..|..:..::|...|
pombe   589 --IVKFLECNMNKHSEGLDYLTWIKQLLAED 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH_DMD-like_rpt1	12..118	CDD:409035	48/110 (44%)
		CH_SF	129..229	CDD:469584	32/110 (29%)
		SPEC	312..525	CDD:238103	52/248 (21%)
		PRK03918	<716..1238	CDD:235175
		SMC_prok_B	<995..1279	CDD:274008
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:413338
		SPEC	2369..2576	CDD:238103
		SPEC	2477..2714	CDD:238103
		WW	2852..2882	CDD:238122
		EFh_DMD_like	2919..3085	CDD:320000
		EF-hand-like motif	2919..2958	CDD:320000
		EF-hand-like motif	2961..2995	CDD:320000
		EF-hand-like motif	3001..3037	CDD:320000
		EF-hand-like motif	3050..3085	CDD:320000
		ZZ_dystrophin	3110..3158	CDD:239074
ain1	NP_594295.1	SAC6	1..616	CDD:227401	181/743 (24%)