Protein Alignment Dys and Dytn

DIOPT Version :10

• Sequence 1: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Sequence 2: NP_001075127.1
• Gene: Dytn / 241073
• MGIID: 2685061
• Length: 653
• Species: Mus musculus
• Alignment Length: 649
• Identity: 164/649 - (25%)
• Similarity: 260/649 - (40%)
• Gaps: 137/649 - (21%)

  Fly  2892 LNEIRFSAYRTAMKLRSVQKRLALDRISMSTACESFDRHGLRAQNDKLIDIPDMTTVLHSLY--- 2953
            ||.:..|.||||.||||||....||.:......:...|.......:..|.:..:...|..|:
Mouse     9 LNRVENSVYRTAFKLRSVQTLCQLDLMDSFLIQQVLWRGRSGESTETSISVQQLFQELRELFQRT 73

  Fly  2954 -------VTIDKIDLTLMLDLAINWILNVYDSQRTGQIRVLSFKVGLVLLCKGHLEEKYRYLFRL 3011
                   |.....:|||.|      ::.::|...:|.::.......||.|.......|||..|:|
Mouse    74 GMGNAAQVHPRAPELTLSL------LMAMFDRTGSGILKRQPVAAALVALSGDSPLTKYRAFFQL 132

  Fly  3012 VADTDRRAD-------QRRLGLLLHDCIQVPRQLGEVAAFGGSNIEPSVRSCLE---QAGISQEA 3066
            .|:.:||.|       :|.|..||.|..|:|..:||  ::....:|.::.||..   .:||.:|
Mouse   133 YAEKNRRGDDSQARMTRRVLRALLTDLQQIPTVVGE--SYTLRPVESAIHSCFRGVLSSGIKEE- 194

  Fly  3067 IDGNQDISIELQHFLGWLQHEPQSLVWLPVLHRLAAAEAAKHQAKCNICKEYPIVGFRYRCLKCF 3131
                        .||.|.|.||..|:|||..:||:|||...|..:|::|:.:||:|.||.||||.
Mouse   195 ------------KFLSWAQSEPLVLLWLPTCYRLSAAETVTHPVRCSVCRTFPIIGLRYHCLKCL 247

  Fly  3132 NFDMCQKCFFFGRNAKNHKLTHPMHEYCTTTTSTEDVRDFTRALKNKFKSRKYFKKHPRVGYLPV 3196
            :||:|:.||..|.:..:|:.:|.:.|.|...::||:.:...|:|:|...     :|..|||.:..
Mouse   248 DFDICELCFLSGLHKNSHEKSHTVMEECVQMSATENTKLLFRSLRNNLP-----QKRQRVGAVGR 307

  Fly  3197 QSVLEGDA-LESPAPSPQHTTHQLQNDMHSRLEMYASRLAQVEYGGTGSNSTPDSDDEHQLIAQY 3260
            |.:|:..| .:|.:..|.....|.:   ..:...|||....||...||               ..
Mouse   308 QWLLDQLASRDSASHGPARLCLQYK---CPKAPGYASSRRAVETAATG---------------VL 354

  Fly  3261 CQ----ALPGTSNGSAPKSPVQVMAAMDAE---QREELEAIIRDLEEENANLQAEYQQLCSKEQS 3318
            ||    ||.|..|...     |.:..:..|   .|:.|..::|:.......|....|:|
Mouse   355 CQRPSPALQGNHNRHG-----QTIVNIKNELWRTRDSLNTLLRERRLLRKQLHRYKQKL------ 408

  Fly  3319 GMPEDSNGMQHSSSSMTGLSGQG----EQGQDMMAEAKL--LRQHKGRLEARMQILEDHNRQLEA 3377
                                 ||    ::.|:...|.|:  |..::..|..::|.:   .|.|:|
Mouse   409 ---------------------QGTYALQEEQNCRFETKIRELTTNQDNLWTKLQQM---RRDLQA 449

  Fly  3378 QLQRLRQLLDEPNGGGSSATSSGLPSAPGSALNSKPNTLQTRSVTASQLNTDSP--------AKM 3434
            .||.|     .|:....:..|....|.|...:....::...:.||     .|.|        ||:
Mouse   450 MLQPL-----HPSSSPQTTASKIFHSLPDDGIRRGGDSSHIKRVT-----RDGPEWELLPNSAKV 504

  Fly  3435 NQQNGHYEHNSKGIMLPGMNSEIQQQHAQLASLAAKHHQHQLSGALNALHQQQQQQLQQQPPQQ 3498
            :::  |....|.|..||    :.:.|...|.|...::|..::...:::.....||...|.||.:
Mouse   505 DRK--HKCQASSGKALP----DSEPQEIILQSTRKQNHPQKMLSKVHSSPSAHQQDTLQIPPTE 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH_DMD-like_rpt1	12..118	CDD:409035
		CH_SF	129..229	CDD:469584
		SPEC	312..525	CDD:238103
		PRK03918	<716..1238	CDD:235175
		SMC_prok_B	<995..1279	CDD:274008
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:413338
		SPEC	2369..2576	CDD:238103
		SPEC	2477..2714	CDD:238103
		WW	2852..2882	CDD:238122
		EFh_DMD_like	2919..3085	CDD:320000	41/185 (22%)
		EF-hand-like motif	2919..2958	CDD:320000	5/48 (10%)
		EF-hand-like motif	2961..2995	CDD:320000	7/33 (21%)
		EF-hand-like motif	3001..3037	CDD:320000	16/42 (38%)
		EF-hand-like motif	3050..3085	CDD:320000	9/37 (24%)
		ZZ_dystrophin	3110..3158	CDD:239074	19/47 (40%)
Dytn	NP_001075127.1	EFh_DMD_DYTN_DTN	36..201	CDD:352774	41/185 (22%)
		EF-hand-like motif	36..75	CDD:319999	4/38 (11%)
		EF-hand-like motif	82..116	CDD:319999	7/39 (18%)
		EF-hand-like motif	122..165	CDD:319999	16/42 (38%)
		EF-hand-like motif	176..201	CDD:319999	9/37 (24%)
		ZZ	226..274	CDD:412288	19/47 (40%)