Protein Alignment Dys and M116.5

DIOPT Version :10

• Sequence 1: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Sequence 2: NP_501432.4
• Gene: M116.5 / 177642
• WormBaseID: WBGene00019792
• Length: 1020
• Species: Caenorhabditis elegans
• Alignment Length: 903
• Identity: 223/903 - (24%)
• Similarity: 365/903 - (40%)
• Gaps: 251/903 - (27%)

  Fly     8 DERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNLKPEKGRMRVHHIN 72
            |.|..:||||||||:|.||..|..| :.|||:|||||..|:|||..||...::.|.|..|.|.|.
 Worm    35 DVRDTMQKKTFTKWVNKHLTKTDHT-IVDLFVDLRDGFALIALLEALTGERIQRENGYTRFHRIQ 98

  Fly    73 NLNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEF-------------------NGQ 118
            |:...:..::...:|||||..:|||.||.||||||||.|.|.|                   |.:
 Worm    99 NVQYCLDFLKMKNIKLVNIRPEDIVEGNGKLTLGLIWTIILNFQVSVIRQRLLLESSQHEQTNEK 163

  Fly   119 HLVKSHSS------NGVEKSLLAWARQYTE--PHGLQLNDFSSSWSDGRAFLMILDAHVEELNLQ 175
            |...|..|      .....:||.||::.|.  |.|..:| ||:||.||.||..|:..:     ..
 Worm   164 HTTNSQDSIHRSETTSARDALLQWAKRTTAEYPRGNVIN-FSNSWRDGLAFNAIIHRY-----RS 222

  Fly   176 AALQQHAL--------KRLHLAFDLAHRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESM 232
            :|:..:.:        :||::||..|.|.|.:|:|||||||.|:.||.|||..||..||:|:
 Worm   223 SAIDWNKINSDSVSNTERLNIAFAAADREFGVERLLDAEDVDTNNPDEKSIITYVSSLYNAL--- 284

  Fly   233 RTRQQEQEQDE-----GQ--DQDPGRVPCTSITDLDEV-----PLDNDQT-----SLGLYTSDSA 280
               .||.|..:     |:  :::.|::.    .|.|.:     .:..|:.     ||.|.:...:
 Worm   285 ---PQEPEMSKFAASGGKRLEEEIGKLQ----ADADHIFEALAVISKDEALQESPSLLLVSKQVS 342

  Fly   281 GSMEQR---------------SSGELKTHSMRPLSTATNASVEISGYQSALEAVLTLLLEDEQLL 330
            ..:||.               |..:|...:..|.|.|......:...:.|...|..|:.:.|.|:
 Worm   343 KKIEQLKVLLKLVEEKKDTFISKCKLVMRTAGPESDAKELDSLMKHVEDAYSDVFELISDKEGLI 407

  Fly   331 ---------SQNLPDPQD----FQTAKLQFHENESFMLKLTEHQE--------------YVGEAL 368
                     |.::|:.:.    |..|..:|...     :|.:.::              ||
 Worm   408 DRCNASNINSDSVPNTESLNLAFAAADPEFGAG-----RLLDAEDVDTNNNPDEKPVITYV---- 463

  Fly   369 EEGSNLINESQ---------KAGAGLSQE------DQNEVRQQMVLLNERWETLRLRALDVQAKI 418
               |:|.|..|         ..|.|..:|      |.:.:.:.:.::::.      .||.....:
 Worm   464 ---SSLKNAPQDPEMSRLAASGGKGFEEEIGKLQADADHIFEALAVMSKD------EALQESPSL 519

  Fly   419 LMRLAEFQKQKLEQLRQFLTSVEDR----ISH----MSDIGPTLEEAEKQLLEAQKLKADLSEQQ 475
            |:...:.:..|:::|::.|..||::    ||.    |...||   ||:.:.|::      |.:|.
 Worm   520 LLYSKQIRFNKIQKLKELLKPVEEKKDTFISECKLVMKTAGP---EADTKELDS------LLKQV 575

  Fly   476 ELVDSLSSMVVIVNDTSGNFNDLEDRLSALGERWSHVVKWSDLRKEKLQQYKCISRWLDAREQDL 540
            |  |:.|.:..:::|..|    |.||.:|           |::..:.:...:.::..|.|.:.:.
 Worm   576 E--DAYSDVFELISDKEG----LIDRCNA-----------SNINSDSVSNTERLNIALAAADAEF 623

  Fly   541 ---KLMESRDV-----TDVGGITQRINELNYCAKDLLELQRYLID----LRQMVAATLQDGD--- 590
               :|:::.||     .|...|...::.||.......|:.:|:..    |.:.:.....|.|
 Worm   624 GAGRLLDAEDVDTNNNPDEKSIITYVSSLNNAFPLEPEMSKYVASGGKRLEEEIGKLQADADHIF 688

  Fly   591 ------DKGERVLIQLESYEDRLDALKQIVEVQTVRIETKGFNFGRDRASYDDSRVVRPEGWVDY 649
                  .|.|.:   .||....||:.:...:::.:::..|.....:|....:...|::..|
 Worm   689 KALEEISKDEAL---QESPSLLLDSKQVSKKIEQLKVLLKPVEEKKDTFISESKLVMKTVG---- 746

  Fly   650 QMIIRFGEDDSQEDD-----------DEHDLASKKRKLRNADNFNALENHIMEHFGYVQEVEQKL 703
                  .|.|::|.|           |..:|.|.|..|  .|..|| .|.|..
 Worm   747 ------PESDAKELDSLMKHVEDAYSDVVELISDKEGL--IDRCNA-SNRIAH------------ 790

  Fly   704 QQLQRQSLRQQCELLKELQAENSRRCGTLPELKKLYEVCELEDPSRNLLLEETHIKQL 761
            .|.:.:.:..:.|||||     :..|.|..:::|:.|        ......:||||::
 Worm   791 PQTETEKITNEIELLKE-----TCSCCTPYQIEKISE--------NYYRFGDTHIKRM 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH_DMD-like_rpt1	12..118	CDD:409035	55/124 (44%)
		CH_SF	129..229	CDD:469584	43/109 (39%)
		SPEC	312..525	CDD:238103	49/262 (19%)
		PRK03918	<716..1238	CDD:235175	13/46 (28%)
		SMC_prok_B	<995..1279	CDD:274008
		SPEC	1174..1365	CDD:238103
		SPEC	1289..1485	CDD:413338
		SPEC	2369..2576	CDD:238103
		SPEC	2477..2714	CDD:238103
		WW	2852..2882	CDD:238122
		EFh_DMD_like	2919..3085	CDD:320000
		EF-hand-like motif	2919..2958	CDD:320000
		EF-hand-like motif	2961..2995	CDD:320000
		EF-hand-like motif	3001..3037	CDD:320000
		EF-hand-like motif	3050..3085	CDD:320000
		ZZ_dystrophin	3110..3158	CDD:239074
M116.5	NP_501432.4	CH_PLEC-like_rpt1	38..142	CDD:409037	53/104 (51%)
		CH_SF	179..285	CDD:469584	44/117 (38%)
		CH_SF	<422..469	CDD:469584	8/58 (14%)
		CH_SF	<604..657	CDD:469584	9/52 (17%)
		GAS2	796..868	CDD:128539	13/53 (25%)