Protein Alignment Dys and fln-1

DIOPT Version :10

• Sequence 1: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Sequence 2: NP_001294364.1
• Gene: fln-1 / 176855
• WormBaseID: WBGene00022048
• Length: 2259
• Species: Caenorhabditis elegans
• Alignment Length: 2329
• Identity: 400/2329 - (17%)
• Similarity: 731/2329 - (31%)
• Gaps: 809/2329 - (34%)

  Fly     3 PGILIDERQH--IQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNLKP--EK 63
            |.|..|:.:.  ||:.|||:|:.:||.....| ::.|..|..||.:|:||...|:..|:..  :|
 Worm    15 PAIRHDDAEWKIIQQNTFTRWVKNHLQKAGET-IESLETDFSDGLKLIALAQVLSHKNVGKFNKK 78

  Fly    64 GRMRVHHINNLNKVITEIQ-QHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFN-GQHLVKSHSS 126
            ...|...:.|::..:...| :..:|::||.|..||..|.||.|||:|.:.|.:: ....::....
 Worm    79 VAFRSQKLENVSLALNFFQNEENIKIINIDSTHIVDHNKKLILGLVWTLILHYSISMGWIQEKRE 143

  Fly   127 NGVEK------SLLAWARQYTEPHGLQLNDFSSSWSDGRAFLMILDAHVEELNLQAALQ------ 179
            :|..|      .||.|.|......|:.:::|:|.|:||.|    |.|.|..: ...||:
 Worm   144 DGDNKEETPKQKLLNWIRNRLPVSGMPISNFTSDWNDGVA----LGALVNSM-APGALEDWENWS 203

  Fly   180 -QHALKRLHLAFDLAHRHFKIEKLL-DAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQD 242
             ..||:....|...|....|:..|: .||.:|. :.|..|:..|:
 Worm   204 PNDALENTEKAMKSAQDLLKVAPLIAPAEMIHP-EIDEMSVMTYL-------------------- 247

  Fly   243 EGQDQDPGRVPC-------TSITDLDEVPLDNDQTSLGLYTSDSAGSMEQRSSGELKTHSMRPLS 300
               .|.|...|.       .:|::||::...||.....|               :|.....:|
 Worm   248 ---SQFPATKPIIMKPKVQATISNLDKILQVNDPREFDL---------------KLSRDGFKP-- 292

  Fly   301 TATNASVEISGYQSALEAVLTLLLEDEQLLSQNLPDPQDFQTA--KLQFHENESFMLKLTEHQEY 363
                   ::|             :.||        |.||...:  |::..|| ::.:|.|..:
 Worm   293 -------KVS-------------IRDE--------DGQDIHLSLKKVEDKEN-AYKVKFTPTK-- 326

  Fly   364 VGEALEEGSNLINESQKAGAGLSQED--QNEVRQQMVLLNERWETLRLRALDVQAKI--LMRLAE 424
                               .|....|  .|:|        ..:||..:....|..::  :.||.:
 Worm   327 -------------------IGFIHVDVAANDV--------HTFETQTIPEASVICQVVPIARLLD 364

  Fly   425 FQKQKLEQLRQFLTSVEDRISHMSDIGPTLEEAEKQLLE--AQKLKADLSEQQELVDSLSSMVVI 487
            :.|                   .:.:|..::.|....:|  .:.:..|.:.::.       .:||
 Worm   365 YNK-------------------TAKVGDDVKFAVVDAIEGPVEAIVVDPTGKEH-------RMVI 403

  Fly   488 VNDTSGNFNDLEDRLSALGERWSHVVKWS--------DLRKEKLQQYKCISRWLDAREQDLKLME 544
            ::.||...:..|.::..:|....:|....        .||.:....:|...|
 Worm   404 LDGTSPGEHSFEYKIPCIGLHSVNVFHKKLPLTGSPFPLRGKPKNSFKVWGR------------- 455

  Fly   545 SRDVTDVGGITQRINELNYCAKDLLELQRYLIDLRQMVAATLQDGDDKGERVLIQLESYEDRLDA 609
                    ||.                               .:|..|.:.|.:.:||.:...:.
 Worm   456 --------GIA-------------------------------PEGIRKNDVVGVHVESLDPEENI 481

  Fly   610 LKQIVEVQTVRIETKGFNFGRDRASYDDSRVVRPEGWVDYQMIIRFGEDDSQEDDDEHDLASKKR 674
            ....:.::.::             ..|.|.:....|:.|....:.|.....|..||...|.....
 Worm   482 ANANISLEVLK-------------PSDGSHLPVSVGYNDESQSMDFEYSPKQAPDDLEVLVKVAG 533

  Fly   675 KLRNADNFNALENHIMEHFGYVQEVEQKLQQ----LQRQSLRQQCELLKELQAENSRRCGTLPEL 735
            ::        :|:|.:.   ...|...|::.    |:...:.:.|....|:..|:......:...
 Worm   534 EV--------IESHKIH---VAPESSSKIRAFGAGLEGGIVNEPCVFDVEMNGESKDLSFAVEGP 587

  Fly   736 KKLYEVCELEDPSRNLLLEET----------------HIKQLEQRYANLSQKLSSQQSESH--TL 782
            .|....|: |.|..:.:|..|                || |.......:::.:...:..:.  |.
 Worm   588 SKAEIGCQ-ERPDGSAILSYTPTVAGVYKVGVLADGKHI-QDSPFVLRVTEPIEGLKPSATRVTG 650

  Fly   783 LAKEKYYNSLTGFKLVL-ADSRDWYKQHAGSASGNELEQRLSHMESLASEISEAKTATEELDDNL 846
            :.:.|.||  .|.|:.. .|:|         ..|.:|   :..:|.|..|::.......|:...|
 Worm   651 IDESKVYN--VGEKIPFRVDTR---------LCGVDL---VPKVEILDPELNPISYGAREITPGL 701

  Fly   847 IEW----------------------------------------------------KQDFGLFYDS 859
            .|:                                                    |:......|:
 Worm   702 FEYTLIPDAPIKHKIDVSVAGVSVPGAPFSVKVKEPTDASKLKIFGPGVDGPVYSKEPTRFTIDA 766

  Fly   860 WHDMKQALQALIQQRGGESLSRQLKQIQD--FVTKVSNQK------------------------- 897
            ......|::..::...||::...:...||  |..|.:.|:
 Worm   767 TQAGPGAVEVALRDDQGENVDLDVLDNQDGSFTVKYTAQRPGAYQLNVVFAGEEISPIEINVKPN 831

  Fly   898 -----VRVSNLE-----VMQEQQHFLN-----------QLLDEMESLRLTYDNIPKHL------- 934
                 :||..||     :....:..:|           ||:||:...|.   |:|..:
 Worm   832 VDVSGIRVEGLENENLLIGSHLRPTINIGKLEPKSKGLQLIDEVNGKRY---NVPMKINPDGTYS 893

  Fly   935 -------IGE-ELQTAWNRLPEQLNERVIK--QTTAIENLNHFAAEYNAIIAMLRSAADSKLNGS 989
                   :|| :||..::.:|  :.|.|::  :.|.:.....:.......:...::..:..|:|:
 Worm   894 TDTPLMEVGEHKLQLLFDEIP--VKEAVVEVIKGTDVNKCKAYGPGLEQAVVGEKAVFELDLDGA 956

  Fly   990 -DGASSQDLR---------------KLEID-VISARNFSEILIKEAEPAQKESLQ-SQIRALNTL 1036
             :||.|.::|               |..:: |..|....|:.||..:..|||.:: |..:|
 Worm   957 GEGALSMEMRGPAKAESRIQDRGNGKCSVEYVAKAPGDYEMAIKFGKDEQKEHVKGSPFKA---- 1017

  Fly  1037 YDQVEQVHREKKEQQTVLQSHIDLIQLRLKETDQWLTDLESNTPKSGISDIVNSNELFQSKSRFQ 1101
                  |...||:...:..|.:|....||.:...::.|                    .||::..
 Worm  1018 ------VVDYKKDPSQITISGLDQPNYRLNQPINFVID--------------------TSKTKDL 1056

  Fly  1102 TLKETCERETTQFRDLNERGGELLLQMDELQDQDRESRYGSLAKQFTRINARWTEVTELVYAKTA 1166
            .:|.|...:..|.:.:..|...        ..:....|:....|....|      ..|::|....
 Worm  1057 PVKATVPSDFAQLQPVVSRSPS--------NPRHHNVRFVPSGKPNVSI------PIEIIYDGLK 1107

  Fly  1167 LLEHISTQLGEFKKFMVSETGYLDKLENKIRNTP--ENAADAEEIMEELDDLENVLRSHS----- 1224
            :.|.:...|.|.:..::....  ||.::.:..||  .||:....:..::.|..||.:..|
 Worm  1108 IDEKLVKVLPEVEPQLIKILH--DKKKDSLTTTPITTNASHEGHVPFDVRDCGNVKKIESRVFGP 1170

  Fly  1225 --EEWLDKIQEI-GNELIDNEFMADSIRRDIDETVQRWTQLQQQAKKRTELLEQKVSEAEQSEKC 1286
              :|.|:.::.. .|.:.|..|..|.    ..|....:....|:...|..::.:|:.
 Worm  1171 DGKERLNHVRSTEQNGIYDVSFPTDM----AGEYCVVFYINGQEVAARVPVMAEKIG-------- 1223

  Fly  1287 IVQFEKWLTRVDDILSDHLDNDVTIVDQPEEFQRLAHEFVANEKNFKEISELIDEHTRNGKVGAA 1351
                     |.:|::.:.      ||..||                      |.||:
 Worm  1224 ---------RKEDVIKEE------IVFHPE----------------------IAEHS-------- 1243

  Fly  1352 NRLQEQLNLMEVRFKYCQAKLSKCTAIQHSYESRLNRAYTDLRNVERSTEVVDVASAGPNTVQTQ 1416
                                 .......|..:::..:|:          ..:.|.:|.|:.|:.:
 Worm  1244 ---------------------PTVLTYNHPIDAKKKKAH----------PAIQVLAAKPDAVRLE 1277

  Fly  1417 YQKCLQIYRTLSEIKSEIESTIKTGRRVCEDRYTKSPKQLSQRIDALKHLYNTL-----GENVTQ 1476
            :                |:..:..|.||. ||...:..:|..         |||     ||:|
 Worm  1278 H----------------IQELVDNGHRVA-DRIVFTATKLGT---------NTLDVFYGGEHV-- 1314

  Fly  1477 SKATLERLLTLARQLEECFDSAD-NLIRRFESPQEVHDRNSILLEFEDVLRRCEDHYNEYNKSCD 1540
                               |..: ..|.:.|..:...:|..:::|.||.:.:.|..|.:...|..
 Worm  1315 -------------------DHVEYEAIGKLEYERIQAERAKVVVEKEDDVDKYEKQYKDEPSSAP 1360

  Fly  1541 QSCMV-------ETRQRIDGLKATYHKLT-SADIIKRLTEMKTTLQNLDNISLETLRAMEHDLKE 1597
            ....|       .|..:.........||. ||:|..:..|...|.|    .::..|.....||:.
 Worm  1361 ADPRVAPTNGKEPTTAQESKKNGNQQKLAPSAEIEHKPLEKYFTFQ----FNVRDLGYQPKDLEA 1421

  Fly  1598 INVPSNPEIEKLQQQVIAIVVDVLKTRFNEATTLAARNTSSPDNDDTEIVVVSDTVRQRRARTPQ 1662
            |.:|..      |::.:|.::|.|     :.|.|.........:.:..|:              |
 Worm  1422 IVMPPT------QKKEVAEIIDNL-----DGTILVKYTPKVHGSHELSIL--------------Q 1461

  Fly  1663 SGESPSSAHTSSSESPTK----------------GVENSPGAVGDQVMPDLLPPQTFRLAESSTL 1711
            :|       .....:|.|                |::|:  .||:        |.||.:....:.
 Worm  1462 NG-------AQLQGTPIKFYVDAYGDGWATVYGPGLQNA--VVGE--------PATFTVCAKGSQ 1509

  Fly  1712 FSQISLNPQKVTNTPPPKPAKTKRKAPSSPAQVVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVN 1776
            ..::|::.:        .|||::.|               |.::|                |...
 Worm  1510 AKELSVSIE--------GPAKSQIK---------------IHDNK----------------DGTC 1535

  Fly  1777 ILESVEPFVPEYVETVQIVDLSEDSDSSVRVDSQGKEMRRSK-SKHSLNETPLP----------- 1829
            ....|.|...||...|::...:. .||..||...|:..:||. |..|.:|..||
 Worm  1536 SAAWVPPVPGEYKVHVKLGGKAV-KDSPFRVLVMGEGQKRSHLSVGSTSEVALPITQQELKGISA 1599

  Fly  1830 ----------------------KVSDNDEDSAEQEEDLLRPSAENTSTPF-LRVEKRRISFDEKR 1871
                                  .||....::.|....:.|........|| ::|:|.::. |..:
 Worm  1600 SIKSPGGIEEPCFVRLLDGGRLGVSFTPREAGEHLITVKRDGKLVPKAPFKIKVDKTQVG-DASK 1663

  Fly  1872 KRVANERDILRDSEEEEPKTPDTPRA------AQVSKPKRWRQLQPEMDALEPESPGRDSFYSPD 1930
            ..|:........:.:......||.:|      ..|..|.:     .|:...|.:|......|:|
 Worm  1664 VEVSGSGKAKGITLQANELLVDTSKAGYGGLSVSVQGPSK-----AELTCKEVKSGLIKVLYTP- 1722

  Fly  1931 KESGFDAEPLVFSDD--EDIPRFSLEMT--------STIDSDSDTSRIMTPSTKNPNPFLSKVLE 1985
            .|.|..|..:.|:|.  :|.| .:::.|        .||..|.:...|..|..:: :.|| |:|.
 Worm  1723 TEPGVYAIAIKFADHHVKDSP-LTVQCTGKSAGRVIQTIQKDVEQHGICLPDQES-HLFL-KLLN 1784

  Fly  1986 SLSSPVDDSNVTLKSPISEEQPQNLDDRVREFDKQAKQMIYKLKLTKAKIEQCH 2039
              :||:|     :.:.:.:.:....|..:|:..:|    .|:||.| .|:|..|
 Worm  1785 --TSPMD-----ITARLMDPKGHTDDIEMRDLGQQ----YYQLKFT-PKMEGIH 1826

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH_DMD-like_rpt1	12..118	CDD:409035	36/111 (32%)
		CH_SF	129..229	CDD:469584	29/113 (26%)
		SPEC	312..525	CDD:238103	33/228 (14%)
		PRK03918	<716..1238	CDD:235175	109/685 (16%)
		SMC_prok_B	<995..1279	CDD:274008	54/310 (17%)
		SPEC	1174..1365	CDD:238103	31/200 (16%)
		SPEC	1289..1485	CDD:413338	28/200 (14%)
		SPEC	2369..2576	CDD:238103
		SPEC	2477..2714	CDD:238103
		WW	2852..2882	CDD:238122
		EFh_DMD_like	2919..3085	CDD:320000
		EF-hand-like motif	2919..2958	CDD:320000
		EF-hand-like motif	2961..2995	CDD:320000
		EF-hand-like motif	3001..3037	CDD:320000
		EF-hand-like motif	3050..3085	CDD:320000
		ZZ_dystrophin	3110..3158	CDD:239074
fln-1	NP_001294364.1	CH_dFLNA-like_rpt1	13..136	CDD:409160	39/121 (32%)
		CH_FLN_rpt2	151..255	CDD:409079	30/132 (23%)
		IG_FLMN	261..358	CDD:214720	26/171 (15%)
		IG_FLMN	367..446	CDD:214720	14/104 (13%)
		IG_FLMN	549..637	CDD:214720	14/89 (16%)
		IG_FLMN	643..737	CDD:214720	16/107 (15%)
		IG_FLMN	740..830	CDD:214720	10/89 (11%)
		IG_FLMN	930..1020	CDD:214720	18/99 (18%)
		IG_FLMN	<1406..1476	CDD:214720	17/105 (16%)
		IG_FLMN	1484..1567	CDD:214720	24/132 (18%)
		Filamin	1561..1650	CDD:395505	16/88 (18%)
		IG_FLMN	1661..1750	CDD:214720	18/95 (19%)
		Filamin	<1789..1842	CDD:395505	11/48 (23%)
		IG_FLMN	1854..1944	CDD:214720
		IG_FLMN	1959..2039	CDD:214720
		IG_FLMN	2045..2133	CDD:214720
		IG_FLMN	2170..2258	CDD:214720