Protein Alignment Dys and DMD

DIOPT Version :10

• Sequence 1: NP_001036722.1
• Gene: Dys / 42327
• FlyBaseID: FBgn0260003
• Length: 3598
• Species: Drosophila melanogaster
• Sequence 2: XP_006724531.1
• Gene: DMD / 1756
• HGNCID: 2928
• Length: 3703
• Species: Homo sapiens
• Alignment Length: 3957
• Identity: 1157/3957 - (29%)
• Similarity: 1842/3957 - (46%)
• Gaps: 810/3957 - (20%)

  Fly     9 ERQHIQKKTFTKWINSHLIDTQCTPVKDLFLDLRDGHRLLALLSTLTQTNLKPEKGRMRVHHINN 73
            ||:.:||||||||:|:.........:::||.||:||.|||.||..||...|..|||..|||.:||
Human    12 EREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNN 76

  Fly    74 LNKVITEIQQHGVKLVNISSDDIVGGNAKLTLGLIWLIALEFNGQHLVKS-----HSSNGVEKSL 133
            :||.:..:|.:.|.||||.|.|||.||.||||||||.|.|.:..::::|:     ..:|. ||.|
Human    77 VNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNS-EKIL 140

  Fly   134 LAWARQYTEPHGLQLN--DFSSSWSDGRAFLMILDAHVEEL---NLQAALQQHALKRLHLAFDLA 193
            |:|.||.|..:. |:|  :|::|||||.|...::.:|..:|   | ....||.|.:||..||::|
Human   141 LSWVRQSTRNYP-QVNVINFTTSWSDGLALNALIHSHRPDLFDWN-SVVCQQSATQRLEHAFNIA 203

  Fly   194 HRHFKIEKLLDAEDVHTHKPDNKSIQMYVMCLYHAMESMRTRQQEQEQDEGQDQDPGRVPCTSIT 258
            .....||||||.|||.|..||.|||.||:..|:..:                   |.:|...:|.
Human   204 RYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVL-------------------PQQVSIEAIQ 249

  Fly   259 DLDEVPLDNDQTS---LGL-----YTSDSAGSMEQRSSGELKTHSMRPL---------------- 299
            :::.:|.....|.   ..|     |:.....|:.|   |..:|.|.:|.
Human   250 EVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQ---GYERTSSPKPRFKSYAYTQAAYVTTSD 311

  Fly   300 --------------------STATNASVEISGYQSALEAVLTLLLEDEQLLSQNLPDPQDFQTAK 344
                                |:...:.|.:..||:|||.||:.||..|..|........|.:..|
Human   312 PTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVK 376

  Fly   345 LQFHENESFMLKLTEHQEYVGEALEEGSNLINESQKAGAG-LSQEDQNEVRQQMVLLNERWETLR 408
            .|||.:|.:|:.||.||..||..|:.||.||      |.| ||::::.||::||.|||.|||.||
Human   377 DQFHTHEGYMMDLTAHQGRVGNILQLGSKLI------GTGKLSEDEETEVQEQMNLLNSRWECLR 435

  Fly   409 LRALDVQAKILMRLAEFQKQKLEQLRQFLTSVEDRISHMSD--IGPTLEEAEKQLLEAQKLKADL 471
            :.:::.|:.:...|.:.|.|||::|..:||..|:|...|.:  :||.||:.::|:.:.:.|:.||
Human   436 VASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDL 500

  Fly   472 SEQQELVDSLSSMVVIVNDTSGNFND--LEDRLSALGERWSHVVKWSD----------LRKEKLQ 524
            .::|..|:||:.|||:|:::||:...  ||::|..||:||:::.:|::          |:.::|.
Human   501 EQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLT 565

  Fly   525 QYKCI-SRWLDAREQDLKLMESRDVTDVGGITQRINELNYCAKDLLELQR---YLIDLRQMVAAT 585
            :.:|: |.||..:|..:..:.:....|...:...:.:|.....||.:.::   .|..|:|.:.:|
Human   566 EEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLST 630

  Fly   586 LQDGDDKGERVLIQLESYEDRL----DALKQIVEVQTVRIETKGFNFGRDRASYDDSRVVRPEGW 646
            |     |.:.|..:.|::.|..    |.|.|.:|..|.:|...   ....:.|...:.|:.....
Human   631 L-----KNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQA---VTTTQPSLTQTTVMETVTT 687

  Fly   647 VD--YQMIIRFGEDDSQEDDDEHDLASKKRKLR-NADNFNALENHIMEHFGYVQEVEQKLQQLQR 708
            |.  .|::::..:::......:     |||::. :::....|:..|.|...::...|..||..:.
Human   688 VTTREQILVKHAQEELPPPPPQ-----KKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEF 747

  Fly   709 QSLRQQCELLKELQAENSRRCGTLPELKKLYEVCE---------LEDPSRN--LLLEE------- 755
            ...|::               |...:||:.....|         |:|.||:  .|:|:
Human   748 AIFRKE---------------GNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVN 797

  Fly   756 -THIK----QLEQRYANLSQKLSSQQS---ESHTLLAKEKYYNSLTGFKLVLADSRDWYK-QHAG 811
             ..||    ||..|:....|.||.:.:   ..:.::|   :||.|...:.:...:.:|.| |...
Human   798 ADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIA---FYNQLQQLEQMTTTAENWLKIQPTT 859

  Fly   812 SASGNELEQRLSHMESLASEISEAKTATEELDDNLIEWKQ----------DFGLFYDSWHDMKQA 866
            .:....::.:|...:...:.:|:.:...|.|....|..|:          ||..|.:.:..:...
Human   860 PSEPTAIKSQLKICKDEVNRLSDLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSD 924

  Fly   867 LQA-----------LIQQRGGESLSRQLKQIQDFVTKVSNQKVRVSNLEVM-------------- 906
            :||           |...|..|::|.....:|...||:|..::.|::.|:|
Human   925 VQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSL 989

  Fly   907 QEQQ---HFLNQLLDEMESLRLTYDNIPKHLIG------EELQTAWNRLPEQLNE---------- 952
            ||||   ::|:..:.||..      ..|..:..      ||::..|.:|..||.|
Human   990 QEQQSGLYYLSTTVKEMSK------KAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMN 1048

  Fly   953 RVIKQTTAIENLNHFAAEYNAIIAMLRSAADSKLNGSDGASSQ---------DLRKLEIDVISAR 1008
            ::.|....|:.|..:.||.:..:.....|    |..|:....|         |::.::..:.|..
Human  1049 KLRKIQNHIQTLKKWMAEVDVFLKEEWPA----LGDSEILKKQLKQCRLLVSDIQTIQPSLNSVN 1109

  Fly  1009 NFSEILIKEAEPAQKESLQSQIRALNTLYDQV-EQVHREKKEQQTVLQSHIDLIQLRLKETDQWL 1072
            ...:.:..||||.....|:::::.|||.:|.: :||:..|:..:..|:..:.| |..|.|..:|:
Human  1110 EGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSL-QKDLSEMHEWM 1173

  Fly  1073 T---------DLESNTPKSGISDIVNSNELFQSKSRFQTLKETCERETTQFRDLNERGGELLLQM 1128
            |         |.|..||          :||.::....:..||..:::..:.:.|.|....::.|.
Human  1174 TQAEEEYLERDFEYKTP----------DELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQA 1228

  Fly  1129 DELQDQDRESRYGSLAKQF----TRINARWTEVTELVYAKTALLEHISTQLGEFKKFMVSETGYL 1189
            ..:..:..:....:|...:    ||:|.:         .||  ||.:.....|...::.....:|
Human  1229 PPVAQEALKKELETLTTNYQWLCTRLNGK---------CKT--LEEVWACWHELLSYLEKANKWL 1282

  Fly  1190 DKLENKIRNTPENAADAEEIMEELDDLENVLRSHSEEWLDKIQEIGNELIDNEFMADSIRRDIDE 1254
            :::|.|::.|......||||.|.||.|||::| |||:..::|:.:...|.|...|.:.|..:::.
Human  1283 NEVEFKLKTTENIPGGAEEISEVLDSLENLMR-HSEDNPNQIRILAQTLTDGGVMDELINEELET 1346

  Fly  1255 TVQRWTQLQQQAKKRTELLEQKVSEAEQSEKCIVQFEKWLTRVDDILSDHLDNDVTIVDQPEEFQ 1319
            ...||.:|.::|.:|.:||||.:..|:::||.:...::.||.:|..|:.::.:.|.....|:|.|
Human  1347 FNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQ 1411

  Fly  1320 RLAHEFVANEKNFKEISELIDEHTRNGKVGAANRLQEQLN-----LMEVRFKYCQAKLSKCTAIQ 1379
            ::..:..::|.:.:|:.    :|.: || .||.|:..|::     |.:|..|:   :|.:..|
Human  1412 KIQSDLTSHEISLEEMK----KHNQ-GK-EAAQRVLSQIDVAQKKLQDVSMKF---RLFQKPA-- 1465

  Fly  1380 HSYESRLNRAYTDLRNVERSTEVVDVASAGPNTVQTQYQKCLQIYRTLSEIKSEIESTIKTGRRV 1444
             ::|.||..:...|..|:.....::..|.....||:|...|:.:|::|||:|||:|..|||||::
Human  1466 -NFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQI 1529

  Fly  1445 CEDRYTKSPKQLSQRIDALKHLYNTLGENVTQSKATLERLLTLARQLEECFDSADNLIRRFESPQ 1509
            .:.:.|::||:|.:|:.|||..||.||..||:.|..||:.|.|:|::.:
Human  1530 VQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRK---------------- 1578

  Fly  1510 EVHDRNSILLEFEDVLRRCEDHYNEYNKSCDQSCMVETRQRIDGL------KATYHKLTSADIIK 1568
               :.|.:               .|:..:.|..  :..|..::|:      :..:.|.|..:|.|
Human  1579 ---EMNVL---------------TEWLAATDME--LTKRSAVEGMPSNLDSEVAWGKATQKEIEK 1623

  Fly  1569 RLTEMKTTLQNLDNI--SLETLRAMEHDLKEINVPSNPEIEKLQQQVIAIVVDVLKTRFNEATTL 1631
            :    |..|:::..:  :|:|:...:..|.|      .::..|....||:.     :|..|...|
Human  1624 Q----KVHLKSITEVGEALKTVLGKKETLVE------DKLSLLNSNWIAVT-----SRAEEWLNL 1673

  Fly  1632 AARNTSSPDNDD------TEIVVVSDT-VRQRRARTPQSGES-------------PSSAHTSSSE 1676
            ........:..|      |:.::.:|| :.:...:.||..|.             |....|....
Human  1674 LLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQA 1738

  Fly  1677 SPTKGVENSPGAVGDQVMPDLLPPQTFRLAESSTLFSQISLNPQKVTNTPPPKPAKTKRKAPSSP 1741
            :      |.....||... .|:.||   ::|.:..|:.||            ...||.:
Human  1739 A------NLMANRGDHCR-KLVEPQ---ISELNHRFAAIS------------HRIKTGK------ 1775

  Fly  1742 AQVVEIRVKNIQNDKMSVQNIDLEPQQGEIVDTVNILESVEPFVPEYVETVQIVDLSEDSDSSVR 1806
               ..|.:|.::.....:|.: |||.:.||...||:.|  |.|..         |::||::.:|:
Human  1776 ---ASIPLKELEQFNSDIQKL-LEPLEAEIQQGVNLKE--EDFNK---------DMNEDNEGTVK 1825

  Fly  1807 -------------VDSQGKEMRRSK-----SKH-------SLNETPLPKVSDNDEDSAEQEEDLL 1846
                         .|.:.:|..:.|     :||       |.......::|........|.:|||
Human  1826 ELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLL 1890

  Fly  1847 RPSAENTSTPFLRVEKRRISFDE---KRKRVANERDILRDSEE-------EEPKTPDTPRAA--- 1898
            :...:        :||:..|..|   :||....:|::.:..||       .|..:.|....|
Human  1891 KCLDD--------IEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEP 1947

  Fly  1899 -QVSKPKRWRQLQPE-------------------MDALEPESPGRDSFYSP-------------- 1929
             |:...||||:::.:                   |..:..:.|...| |.|
Human  1948 TQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEIS-YVPSTYLTEITHVSQAL 2011

  Fly  1930 -DKESGFDAEPLVFSDDEDIPRFSLEMTSTIDSDSDTSRIMTPSTKNPNPFLSKVLESLSSPVDD 1993
             :.|...:|..|...|.||:.:....:.:..||       :..|:...:...||...:|.|....
Human  2012 LEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDS-------LQQSSGRIDIIHSKKTAALQSATPV 2069

  Fly  1994 SNVTLKSPIS------EEQPQNLDDRVREFDKQA---KQMIYKLKLTKAKIEQCHESEAED-LRL 2048
            ..|.|:..:|      |:..:...||...||:..   ::..|.:|:....:     :|||. ||.
Human  2070 ERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWL-----TEAEQFLRK 2129

  Fly  2049 LIAPD------------------------AATLISQGDSLVLETHGRQGSI-------------- 2075
            ...|:                        ..||.:.|:.::.::.....||
Human  2130 TQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQE 2194

  Fly  2076 ---------SRLVMRTQII--------------------------------LREQFREVQ----- 2094
                     .||..:..|:                                |:|:..:|:
Human  2195 VCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEE 2259

  Fly  2095 --------QARSKTSGS---GAPAPPLDSVNIE-ELVTKGLRRINV---LIEK----TVDLKSST 2140
                    :..::|.|.   .||..|.:...:| :|....|:.|.|   |.||    ...:|...
Human  2260 LPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLG 2324

  Fly  2141 DLEKRMEDINERHDDLQVIVS-----------------------AIGKNAQMPKVTPLM------ 2176
            .|||::||:.|:.:.|.:.:|                       .|...|:.|.|..::
Human  2325 QLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHL 2389

  Fly  2177 ------MNEIEKTKNNLIAHADSIELSLTELR-NGPRISNGKERPDASSAATMSCRSE--YNNE- 2231
                  ...:::...:|.:...::...|.||| ..|.::.|.....||...|::..::  ...|
Human  2390 YKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKET 2454

  Fly  2232 -------PSG----TGALAGSFDKSVLQISDWLTWEQNMIKIQSVLVDDGDAVRLAIEKQEKVLR 2285
                   ||.    ..||| .|:::..:::|||:....:||.|.|:|.|.:.:...|.||:..::
Human  2455 AISKLEMPSSLMLEVPALA-DFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQ 2518

  Fly  2286 ELKMKKPQLNELVHTAEVLKGDVKRQQLQEKELKQFSLAPHCSADLDYMRCCLKVTRLREHWDET 2350
            :|:.::|||.||:..|:.||.....|:           |.....|        ::.|::..|||.
Human  2519 DLEQRRPQLEELITAAQNLKNKTSNQE-----------ARTIITD--------RIERIQNQWDEV 2564

  Fly  2351 SQCVLQRAAQLKNMLSDS-QRFEAKRLELEKWLARMEQRAERMGTIATTADILEAQQKEQKSFHA 2414
            .:.:..|..||..||.|| |..|||. |.|:.|.:...:.|.......|.|.::.:..|.|....
Human  2565 QEHLQNRRQQLNEMLKDSTQWLEAKE-EAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAK 2628

  Fly  2415 ELHQNKQHFDIFNELTQKLIAVYPNDDTTRIKKMTEVINQRYANLNSGVINRGKQLHAAVHSLQS 2479
            :|.|.:.:.|:.|:|..||:..|..|||.::..:||.||..:.:::..|..|...|......||.
Human  2629 DLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQ 2693

  Fly  2480 FDRAMDQFLAFLSETETLCENAESDIERNPLM------------FKDLQSEIETHRVVYDRLDGT 2532
            |...:::|||:|:|.||.....:....:..|:            ::|||.|||.|..||..||..
Human  2694 FPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDEN 2758

  Fly  2533 GRKLLGSLTSQEDAVMLQRRLDEMNQRWNNLKSKSIAIRNRLESNSEHWNALLLSLRELTEWVIR 2597
            .:|:|.||...:|||:||||||.||.:|:.|:.||:.||:.||::|:.|..|.|||:||..|:..
Human  2759 SQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQL 2823

  Fly  2598 KDTELSTLGLGPVRGDAVSLQKQLDDHKAFRRQLEDKRPIVESNLTSGRQYIANEAAVSDTSDTE 2662
            ||.|||.  ..|:.||..::|||.|.|:||:|:|:.|.|::.|.|.:.|.::..:    .....|
Human  2824 KDDELSR--QAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQ----PLEGLE 2882

  Fly  2663 ANHDSDSRYMSAEEQSRELTRSIRREVGKLSEQWNNLIDRSDNWKHRLDEYMTKMRQFQKILEDL 2727
            ..: .:.|.:..||:::.:||.:|::..:::.:|..|...|.:|:.::||.:.::|:.|:..::|
Human  2883 KLY-QEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQEATDEL 2946

  Fly  2728 SSRVALAEQTKTSWLPPSS--VGEANEQMQQLQRLRDKMTTASALLDDCNEQQSFFTANQVLVPT 2790
            ..::..||..|.||.|...  :....:.:::::.||.::......:...|:.....|...:.:..
Human  2947 DLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSP 3011

  Fly  2791 PCLSKLEDLNTRMKLLQIAMDERQKVLCQAGAQQTHENGDDGRTTSNSGTIGPLPN--LGQSVKP 2853
            ..||.|||||||.||||:|:::|        .:|.||...|         .||...  |..||:.
Human  3012 YNLSTLEDLNTRWKLLQVAVEDR--------VRQLHEAHRD---------FGPASQHFLSTSVQG 3059

  Fly  2854 PWERATTAANVPYYIDHERETTHWDHPEMIELMKGLADLNEIRFSAYRTAMKLRSVQKRLALDRI 2918
            |||||.:...|||||:||.:||.||||:|.||.:.|||||.:||||||||||||.:||.|.||.:
Human  3060 PWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLL 3124

  Fly  2919 SMSTACESFDRHGLRAQNDKLIDIPDMTTVLHSLYVTIDK-----IDLTLMLDLAINWILNVYDS 2978
            |:|.||::.|:|.|: |||:.:||..:...|.::|..:::     :::.|.:|:.:||:|||||:
Human  3125 SLSAACDALDQHNLK-QNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDT 3188

  Fly  2979 QRTGQIRVLSFKVGLVLLCKGHLEEKYRYLFRLVADTDRRADQRRLGLLLHDCIQVPRQLGEVAA 3043
            .|||:|||||||.|::.|||.|||:||||||:.||.:....|||||||||||.||:||||||||:
Human  3189 GRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVAS 3253

  Fly  3044 FGGSNIEPSVRSCLEQAGISQEAIDGNQDISIELQHFLGWLQHEPQSLVWLPVLHRLAAAEAAKH 3108
            |||||||||||||.:.|         |....||...||.|::.||||:||||||||:||||.|||
Human  3254 FGGSNIEPSVRSCFQFA---------NNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKH 3309

  Fly  3109 QAKCNICKEYPIVGFRYRCLKCFNFDMCQKCFFFGRNAKNHKLTHPMHEYCTTTTSTEDVRDFTR 3173
            |||||||||.||:|||||.||.||:|:||.|||.||.||.||:.:||.||||.|||.||||||.:
Human  3310 QAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAK 3374

  Fly  3174 ALKNKFKSRKYFKKHPRVGYLPVQSVLEGDALE-------------SPAPSPQHTTHQLQNDMHS 3225
            .|||||::::||.||||:||||||:|||||.:|             :||.||| .:|   :|.||
Human  3375 VLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQ-LSH---DDTHS 3435

  Fly  3226 RLEMYASRLAQVEYGGTGS----NSTPDS--DDEHQLIAQYCQALPGTSNGSAPKSPVQVMAAMD 3284
            |:|.||||||::| ...||    :.:|:.  ||||.||..|||:|...|..|.|:||.|::.:::
Human  3436 RIEHYASRLAEME-NSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLE 3499

  Fly  3285 AEQREELEAIIRDLEEENANLQAEYQQLCSKEQSGMPEDSNGMQ--HSSSSMTGLSGQGEQGQDM 3347
            :|:|.|||.|:.||||||.||||||.:|  |:|    .:..|:.  .|...|...|.|..:..::
Human  3500 SEERGELERILADLEEENRNLQAEYDRL--KQQ----HEHKGLSPLPSPPEMMPTSPQSPRDAEL 3558

  Fly  3348 MAEAKLLRQHKGRLEARMQILEDHNRQLEAQLQRLRQLLDEP------NGGGSSATSSGLPSAPG 3406
            :||||||||||||||||||||||||:|||:||.||||||::|      ||...|:.|:.|..:..
Human  3559 IAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDS 3623

  Fly  3407 SA-------------------LNSKPNTLQT-RSVTASQLNTDSPAKMNQQNGHYEH 3443
            |.                   |.|.|....| ......|||...|:......|...|
Human  3624 SQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGHNVGSLFH 3680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dys	NP_001036722.1	CH_DMD-like_rpt1	12..118	CDD:409035	55/105 (52%)
		CH_SF	129..229	CDD:469584	46/104 (44%)
		SPEC	312..525	CDD:238103	85/227 (37%)
		PRK03918	<716..1238	CDD:235175	131/625 (21%)
		SMC_prok_B	<995..1279	CDD:274008	74/306 (24%)
		SPEC	1174..1365	CDD:238103	55/195 (28%)
		SPEC	1289..1485	CDD:413338	62/200 (31%)
		SPEC	2369..2576	CDD:238103	74/218 (34%)
		SPEC	2477..2714	CDD:238103	89/248 (36%)
		WW	2852..2882	CDD:238122	18/29 (62%)
		EFh_DMD_like	2919..3085	CDD:320000	89/170 (52%)
		EF-hand-like motif	2919..2958	CDD:320000	14/38 (37%)
		EF-hand-like motif	2961..2995	CDD:320000	20/33 (61%)
		EF-hand-like motif	3001..3037	CDD:320000	24/35 (69%)
		EF-hand-like motif	3050..3085	CDD:320000	14/34 (41%)
		ZZ_dystrophin	3110..3158	CDD:239074	33/47 (70%)
DMD	XP_006724531.1	CH_DMD_rpt1	11..121	CDD:409080	57/108 (53%)
		CH_DMD_rpt2	136..246	CDD:409082	48/131 (37%)
		SPEC	341..558	CDD:238103	83/222 (37%)
		SPEC	560..827	CDD:413338	57/294 (19%)
		235kDa-fam	<763..>1938	CDD:130673	289/1324 (22%)
		SPEC	1049..1263	CDD:238103	48/239 (20%)
		SPEC	1878..2102	CDD:413338	47/239 (20%)
		SPEC	2105..2320	CDD:238103	32/219 (15%)
		SPEC	2321..2579	CDD:413338	61/277 (22%)
		SPEC	2472..2688	CDD:238103	68/236 (29%)
		SPEC	2690..2933	CDD:238103	89/249 (36%)
		Spectrin	2934..3040	CDD:395348	29/113 (26%)
		WW	3059..3088	CDD:238122	18/28 (64%)
		EFh_DMD	3125..3286	CDD:320004	89/170 (52%)
		EF-hand-like motif	3125..3164	CDD:320004	14/39 (36%)
		EF-hand-like motif	3171..3205	CDD:320004	20/33 (61%)
		EF-hand-like motif	3211..3247	CDD:320004	24/35 (69%)
		EF-hand-like motif	3260..3286	CDD:320004	14/34 (41%)
		ZZ_dystrophin	3311..3359	CDD:239074	33/47 (70%)