Protein Alignment ChT and SLC5A4

DIOPT Version :10

• Sequence 1: NP_650743.1
• Gene: ChT / 42245
• FlyBaseID: FBgn0038641
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: XP_016884409.1
• Gene: SLC5A4 / 6527
• HGNCID: 11039
• Length: 689
• Species: Homo sapiens
• Alignment Length: 659
• Identity: 150/659 - (22%)
• Similarity: 255/659 - (38%)
• Gaps: 192/659 - (29%)

  Fly    40 LAGRSIGLFVGIFTMTATWVGGGYI-----NGTAEAIYTSGLVWCQAPFGYALSLVFGGIFFANP 99
            ||||.:..:....::.|:.:|..:.     .|.|..:.|....|..:    .:.|:.|.||.  |
Human    90 LAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSS----VMLLILGWIFV--P 148

  Fly   100 MR-KQGYITMLDPLQDSF-GERMGGLLFLPAL--CGEVFWAAGILAALGAT-LSVIIDMDHRTSV 159
            :. |.|.:||.:.|:..| |||:...|.:.:|  |..:..:|.|.|  ||. :.:.:.:|...::
Human   149 IYIKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFA--GAIFIKLALGLDLYLAI 211

  Fly   160 ILSSCIAIFYTLFGGLYSVAYTDVIQLFCIFIGLWMCIPFAWSNEHVGSLSDLEVDWIGH----V 220
            .:...:...||..|||.||.|||.:|...:.||.::.:.||: || ||........::..    |
Human   212 FILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAF-NE-VGGYESFTEKYVNATPSVV 274

  Fly   221 E------------PKKHWLYI--DYGLLLVFGGIPW------------------QVYFQRVLSSK 253
            |            |:....:|  |    .|.|.|||                  ||..||.|..|
Human   275 EGDNLTISASCYTPRADSFHIFRD----AVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGK 335

  Fly   254 TAGRAQLLSYVAAAGCILMA----------IPPVLIGAI------AKATPWNETDYKGPYPLTVD 302
            .      :|:|.|| ||:.|          :.|.:|..|      |...|.....:.|   :.|.
Human   336 D------MSHVKAA-CIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCG---VDVG 390

  Fly   303 ETSMILPMVLQYLTPDFVSFFGLGAVSAAVMSSADSSVLSAASMFARNVYKLIFRQKASEMEIIW 367
            .|:...|.::..|.|..:....|..:.|::|||..|...||:::|..::|..: |::|||.|::.
Human   391 CTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKM-RKQASEKELLI 454

  Fly   368 VMRVAIIVVGILATIMALTIPSIYGLWSMCSDLVYVILFPQLLMVVHFKKHCNTY-GSLSAYIVA 431
            ..|:.:::         ||:.||  :|      |.::...|...::|:.:..::| |...|.:..
Human   455 AGRIFVLL---------LTVVSI--VW------VPLVQVSQNGQLIHYTESISSYLGPPIAAVFV 502

  Fly   432 LAI---RLSGGEAILGLAPLIKYPGYDEETKEQMFPFRTMAMLLSLVTLISVSWWTKMMFESGK- 492
            |||   |::...|..||                     .:.:.:.|:.:|     |:..:.:|.
Human   503 LAIFCKRVNEQGAFWGL---------------------MVGLAMGLIRMI-----TEFAYGTGSC 541

  Fly   493 LPPS----------YDYFRCVVNIPEDVQRVGDPSESGEQLSVMAGP------------LARSYG 535
            |.||          |.||..|:.....:..:|        :|::..|            |..|..
Human   542 LAPSNCPKIICGVHYLYFSIVLFFGSMLVTLG--------ISLLTKPIPDVHLYRLCWVLRNSTE 598

  Fly   536 AATMAGKDERNGRINPALESDD----DLP----------------VAEARRINQETAQAQVKKML 580
            .......:|::..     |:||    |.|                :.:..::.:|..:|..||:.
Human   599 ERIDIDAEEKSQE-----ETDDGVEEDYPEKSRGCLKKAYDLFCGLQKGPKLTKEEEEALSKKLT 658

  Fly   581 DNATGVKPS 589
            |  |..:||
Human   659 D--TSERPS 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	122/506 (24%)
SLC5A4	XP_016884409.1	SLC5-6-like_sbd	76..689	CDD:444915	150/659 (23%)