Protein Alignment ChT and SLC5A3

DIOPT Version :10

• Sequence 1: NP_650743.1
• Gene: ChT / 42245
• FlyBaseID: FBgn0038641
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_008864.4
• Gene: SLC5A3 / 6526
• HGNCID: 11038
• Length: 718
• Species: Homo sapiens
• Alignment Length: 732
• Identity: 158/732 - (21%)
• Similarity: 258/732 - (35%)
• Gaps: 260/732 - (35%)

  Fly     1 MINIAGVVSIVLFYLLILVVGIWAGRKKQSGNDSEEEVMLAGRSIGLFVGIFTMTATWVGGG--- 62
            :::.|.:..:.|:::|::.:|.:|..|  |...:.....|||||:           |||..|
Human     4 VLDTADIAIVALYFILVMCIGFFAMWK--SNRSTVSGYFLAGRSM-----------TWVAIGASL 55

  Fly    63 YINGTAEAIYTSGLVWCQAPFGYA----------LSLVFGGIFFANPMRKQGYITMLDPLQDSFG 117
            :::......:. ||....|..|:|          |..:.|.:|....:| .|..||.:.|...||
Human    56 FVSNIGSEHFI-GLAGSGAASGFAVGAWEFNALLLLQLLGWVFIPIYIR-SGVYTMPEYLSKRFG 118

  Fly   118 ERMGGLLF--------------LPALCGEVFWAAGILAALGATLSVIIDMDHRTSVILSSCIAIF 168
            .....:.|              :....|.:|    |..:||..|.|        ||||...:...
Human   119 GHRIQVYFAALSLILYIFTKLSVDLYSGALF----IQESLGWNLYV--------SVILLIGMTAL 171

  Fly   169 YTLFGGLYSVAYTDVIQLFCIFIG-LWMCIPFAWSNEHVGSLSDLEVDWIGHVEPKKHWLYID-- 230
            .|:.|||.:|.|||.:|...:.|| |.:.|           :|.:|:.  |..|.|:.::...
Human   172 LTVTGGLVAVIYTDTLQALLMIIGALTLMI-----------ISIMEIG--GFEEVKRRYMLASPD 223

  Fly   231 -YGLLLVFG-------------------------GIPW------------------QVYFQRVLS 251
             ..:||.:.                         .:||                  ||..||||:
Human   224 VTSILLTYNLSNTNSCNVSPKKEALKMLRNPTDEDVPWPGFILGQTPASVWYWCADQVIVQRVLA 288

  Fly   252 SKTAGRAQLLSYVAAAGCILMA-----IPPVLI---GAIAKATPWNETDYKGPYPLTVDETSMI- 307
            :|....|:        |..|||     :|..:|   |.|::.             |..|:.:.|
Human   289 AKNIAHAK--------GSTLMAGFLKLLPMFIIVVPGMISRI-------------LFTDDIACIN 332

  Fly   308 ------------------LPMVLQYLTPDFVSFFGLGAVSAAVMSSADSSVLSAASMFARNVYKL 354
                              .|.::..|.|..:....:..:.||:||..||...||:::|..:||||
Human   333 PEHCMLVCGSRAGCSNIAYPRLVMKLVPVGLRGLMMAVMIAALMSDLDSIFNSASTIFTLDVYKL 397

  Fly   355 IFRQKASEMEIIWVMRVAIIVVGILATIMALTIPSIYGLWSMCSDLVYVIL----------FPQL 409
            | |:.||..|::.|.|   |.|..:..|....:|.|.   .|....:|:.:          ...|
Human   398 I-RKSASSRELMIVGR---IFVAFMVVISIAWVPIIV---EMQGGQMYLYIQEVADYLTPPVAAL 455

  Fly   410 LMVVHFKKHCNT----YGSLSAYIVALAIRLSGGEAILGLAPLIKY-----------PGYDEETK 459
            .::..|.|.||.    ||.::.:::. |:||     ||..|    |           ||:.::.
Human   456 FLLAIFWKRCNEQGAFYGGMAGFVLG-AVRL-----ILAFA----YRAPECDQPDNRPGFIKDI- 509

  Fly   460 EQMFPFRTMAMLLSLVTLI--------------SVSWWTK--MMFESGKLPPSYDY-------FR 501
            ..|:....:..:..|:|:|              :.::|:|  ::.:....|....|       .|
Human   510 HYMYVATGLFWVTGLITVIVSLLTPPPTKEQIRTTTFWSKKNLVVKENCSPKEEPYKMQEKSILR 574

  Fly   502 CVVN--------------------IPEDVQRVGDPSESGEQLSVMA-----GPL-ARSYGAATMA 540
            |..|                    .||||..:....|.|..::.:.     .|: |.|.|.|.:.
Human   575 CSENNETINHIIPNGKSEDSIKGLQPEDVNLLVTCREEGNPVASLGHSEAETPVDAYSNGQAALM 639

  Fly   541 GKDERNGRINPALESDD 557
            |:.||.      .|:||
Human   640 GEKERK------KETDD 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	133/613 (22%)
SLC5A3	NP_008864.4	SLC5sbd_SMIT	9..718	CDD:271382	157/727 (22%)