Protein Alignment ChT and Slc5a4b

DIOPT Version :10

• Sequence 1: NP_650743.1
• Gene: ChT / 42245
• FlyBaseID: FBgn0038641
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_075708.2
• Gene: Slc5a4b / 64454
• MGIID: 1890478
• Length: 660
• Species: Mus musculus
• Alignment Length: 700
• Identity: 158/700 - (22%)
• Similarity: 264/700 - (37%)
• Gaps: 194/700 - (27%)

  Fly     3 NIAGVVSIVLFYLLILVVGIWAGRKKQSGNDSEEEVMLAGRSIGLFVGIFTMTATWVGGGYINGT 67
            |.|.:..||::::::|.||:|:  ..:|...:.....|||..:..:....::.|:.:|..:..|.
Mouse    25 NAADISVIVIYFIVVLAVGLWS--MVRSNRGTVGGFFLAGHDMAWWPMGASLFASNIGSNHFVGL 87

  Fly    68 AEAIYTSGLVWCQAPFGYALS-LVFGGIFFANPMR-KQGYITMLDPLQDSFGER-------MGGL 123
            |.....||:......:...|. ||.|.:|.  |:. |.|.:||.:.|:..||.:       :..|
Mouse    88 AGTGAASGIAIAAVEWNALLMVLVLGWVFL--PIYIKAGVLTMPEYLRKRFGGKRLQIYLSVLSL 150

  Fly   124 LFLPAL-------CGEVFWAAGILAALGATLSVIIDMDHRTSVILSSCIAIFYTLFGGLYSVAYT 181
            ..:.||       .|.:|    |..|||..|.:        :|.:...|..|||:.|||.||.||
Mouse   151 FIMVALQTSSIIFSGAIF----IQLALGLNLYL--------AVFILLAITAFYTVAGGLASVIYT 203

  Fly   182 DVIQLFCIFIGLWMCIPFAWSNEHVGSLSDLEVDWIGHV------------------EPKKHWLY 228
            |.:|.|.:.:|..:.:.||::  .||........::..:                  :|....::
Mouse   204 DSVQTFIMLLGSLILMGFAFA--EVGGYESFTEKYMNAIPSVVEGDNLTISPKCYTPQPDSFHVF 266

  Fly   229 IDYGLLLVFGGIPW------------------QVYFQRVLSSKTAGRAQLLSYVAAAGCIL---- 271
            .|    .|.|.|||                  ||..||.|..|.      :|:|.|| |||
Mouse   267 RD----PVTGDIPWPGLIFGMTILAIWYWCADQVIVQRCLCGKN------MSHVKAA-CILCGYL 320

  Fly   272 ------MAIPPVLIGAIAKATPWNETDYKGPYPLTVDETSMILP--------------------M 310
                  :.:.|.:|..|                |..|:.:.::|                    :
Mouse   321 KLLPMFLMVMPGMISRI----------------LYTDKVACVVPSECEKQCGTAVGCTNYAYPTL 369

  Fly   311 VLQYLTPDFVSFFGLGAVSAAVMSSADSSVLSAASMFARNVYKLIFRQKASEMEIIWVMRVAIIV 375
            ||: |.||.:....|..:.|::|||..|...||:::|..::|..| |:||||.|::...|:..:|
Mouse   370 VLE-LMPDGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKI-RKKASERELMIAGRIFGMV 432

  Fly   376 VGILATIMALTIPSIYGLWSMCSDLVYVI------LFPQL---LMVVHFKKHCNTYGSLSAYIVA 431
               |..:..|.:|.:.  .|....|.:.|      |.|.|   .|:..|.|..|..|:....:|.
Mouse   433 ---LIAVSILWVPLVQ--VSQNGQLFHYIGSVSSYLGPPLGAVFMLAIFFKRVNEQGAFWGLMVG 492

  Fly   432 LAIRLSGGEAILGLAPLIKYPGYDEETKEQMFP--------------FRTMAMLLSLVTLISVSW 482
            |         ::||..||....|.  |...:.|              |..:...:|::.::.||:
Mouse   493 L---------VVGLIRLIAEFVYG--TGSCVAPSNCPKIICGVHYMYFAIILFFVSIIVILGVSF 546

  Fly   483 WTKMMFESGKLPPSYDYFRC-------VVNIPEDVQRVGDPSESG----EQLSVMAGPLARSYGA 536
            .|:      .:|..:.|..|       ...|..|.:.:....|:|    |......|.|.|:  .
Mouse   547 LTE------PIPDVHLYRLCWSLWNNTEERIDLDAEELETQEEAGGALEEDSEQSRGCLKRA--C 603

  Fly   537 ATMAGKDERNGRINPALESDDDLPVAEARRINQETAQAQVKKMLDNATGV 586
            ..:.|..    ...|.|..:::   |..|:...:|::..:.:.:.|...|
Mouse   604 CLLCGLQ----NTGPKLTKEEE---AALRQKFSDTSEKPLWRTVMNINAV 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	134/578 (23%)
Slc5a4b	NP_075708.2	SLC5-6-like_sbd	27..660	CDD:444915	156/697 (22%)