Protein Alignment ChT and Slc5a4

DIOPT Version :10

• Sequence 1: NP_650743.1
• Gene: ChT / 42245
• FlyBaseID: FBgn0038641
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_001099853.1
• Gene: Slc5a4 / 294341
• RGDID: 1306923
• Length: 671
• Species: Rattus norvegicus
• Alignment Length: 681
• Identity: 159/681 - (23%)
• Similarity: 272/681 - (39%)
• Gaps: 165/681 - (24%)

  Fly     3 NIAGVVSIVLFYLLILVVGIWAGRKKQSGNDSEEEVMLAGRSIGLFVGIFTMTATWVGGGYINGT 67
            |.|.:..||:::::::.||:||..|  :...:.....|||||:..:....::.|:.:|.|:..|.
  Rat    36 NPADISVIVIYFVVVMAVGVWAMVK--TNRSTVGGFFLAGRSMTWWPMGASLFASNIGSGHFVGL 98

  Fly    68 AEAIYTSGL-VWCQAPFGYALSLVFGGIFFANPMRKQGYITMLDPLQDSF-GERMGGLLFLPAL- 129
            |.....:|: |.......:||.||.|. ||.....|.|.:||.:.|:..| |:|:  .::|..|
  Rat    99 AGTGAATGIAVTAFESHSFALLLVLGW-FFVPIYIKAGVMTMPEYLRKRFGGKRL--QIYLSVLS 160

  Fly   130 ---C-----------GEVFWAAGILAALGATLSVIIDMDHRTSVILSSCIAIFYTLFGGLYSVAY 180
               |           |.:|    |..|||..|.:.|       .||.:..|:| |:.|||.||.|
  Rat   161 LFICVILTISADIFSGAIF----IKLALGLDLYLAI-------FILLAITAVF-TITGGLASVIY 213

  Fly   181 TDVIQLFCIFIGLWMCIPFAWSNEHVGSLSDLEVDWIGHV------------------EPKKHWL 227
            ||.:|...:.:|.::.:.:|:  ..||........::..:                  :|....:
  Rat   214 TDTLQAIIMLVGSFILMIYAF--VEVGGYESFTEKYMNAIPSVVEGDNLTISPKCYTPQPDSFHI 276

  Fly   228 YIDYGLLLVFGGIPW------------------QVYFQRVLSSKTAGRAQLLSYVAAAGCIL--- 271
            :.|    .|.|.|||                  ||..||.|..|.      :|:|.|| ||:
  Rat   277 FRD----AVTGDIPWPGTAFGMPITALWYWCINQVIVQRCLCGKN------MSHVKAA-CIVCGY 330

  Fly   272 --------MAIPPVL-----IGAIAKATPWNETDYKGPYPLTVDETSMILPMVLQYLTPDFVSFF 323
                    |.:|.::     ...:|...|.......|   :.|..|:...||::..|.|..:...
  Rat   331 LKLLPIFFMVMPGMISRILYTDMVACVVPSECVKQCG---VDVGCTNYAYPMLVLKLMPMGLRGL 392

  Fly   324 GLGAVSAAVMSSADSSVLSAASMFARNVYKLIFRQKASEMEIIWVMRVAIIVVGILATIMALTIP 388
            .|..:.|::|||..|...||:::|..::|..| |:||||.|::...|:.:.|: |:.:|:.:.|.
  Rat   393 MLSVMLASLMSSLTSIFNSASTLFTMDLYTKI-RKKASERELLIAGRLFVSVL-IVTSILWVPIV 455

  Fly   389 SIYGLWSMCSDLVYV------ILFPQL---LMVVHFKKHCNTYGSLSAYIVALAIRLSGGEAILG 444
            .:    |....|::.      .|.|.:   .:|..|.|..|..|:....:|.|         :||
  Rat   456 EV----SQGGQLIHYTEAISSYLGPPIAAVFLVAIFCKRVNEQGAFWGLMVGL---------VLG 507

  Fly   445 LAPLIKYPGYDEETKEQMFP--------------FRTMAMLLSLVTLISVSWWTKMMFESGKLPP 495
            |..:|....|.  |...:.|              :..:...:|::.::.||:.||      .:|.
  Rat   508 LIRMIAEFSYG--TGSCLAPSSCPKVICGVHYLYYAIILFFVSILVILGVSYLTK------PIPD 564

  Fly   496 SYDYFRCVVNIPEDVQRVGDPSESGEQLSVMAGPLARSYGAATMAGKDERNGRINPALESDDDLP 560
            .:.|..|......:.:|:...:|..|:            ..|....::::..:....|:...||.
  Rat   565 VHLYRLCWSLRNSEEERIDLDAEDREE------------NEADARTEEDQTEKPRGCLKKTYDLC 617

  Fly   561 VAEAR---RINQETAQAQVKKMLDNATGVKP 588
            ....|   ::.:|..:|..||:.|  |..||
  Rat   618 CGLQRAEPKLTKEEEEALKKKLTD--TSEKP 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	134/565 (24%)
Slc5a4	NP_001099853.1	SLC5-6-like_sbd	38..671	CDD:444915	158/679 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	583..604		3/32 (9%)