Protein Alignment ChT and Slc5a1

DIOPT Version :10

• Sequence 1: NP_650743.1
• Gene: ChT / 42245
• FlyBaseID: FBgn0038641
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_037165.1
• Gene: Slc5a1 / 25552
• RGDID: 3713
• Length: 665
• Species: Rattus norvegicus
• Alignment Length: 682
• Identity: 151/682 - (22%)
• Similarity: 265/682 - (38%)
• Gaps: 162/682 - (23%)

  Fly     3 NIAGVVSIVLFYLLILVVGIWAGRKKQSGNDSEEEVMLAGRSIGLFVGIFTMTATWVGGGYI--- 64
            |.|.:..||:::::::.||:||......|  :.....|||||:..:....::.|:.:|.|:.
  Rat    25 NAADISVIVIYFVVVMAVGLWAMFSTNRG--TVGGFFLAGRSMVWWPIGASLFASNIGSGHFVGL 87

  Fly    65 --NGTAEAIYTSGLVWCQAPFGYALSLVFGGIFFANPMRKQGYITMLDPLQDSFGER-------- 119
              .|.|..|...|..|....|...|..:|..|:.     |.|.:||.:.|:..||.:
  Rat    88 AGTGAAAGIAMGGFEWNALVFVVVLGWLFVPIYI-----KAGVVTMPEYLRKRFGGKRIQIYLSV 147

  Fly   120 MGGLLFL-PALCGEVFWAAGILAALGATLSVIIDMDHRTSVILSSCIAIFYTLFGGLYSVAYTDV 183
            :..||:: ..:..::|..|       ..:::.:.:|...::.:...|...||:.|||.:|.|||.
  Rat   148 LSLLLYIFTKISADIFSGA-------IFINLALGLDIYLAIFILLAITALYTITGGLAAVIYTDT 205

  Fly   184 IQLFCIFIGLWMCIPF---------AWSNEHVGSLSDLEVDWIGHVEPKKHWLYIDYGLLLVF-- 237
            :|...:.:|.::...|         |:.::::.::..|..|  |::..|:...........:|
  Rat   206 LQTAIMLVGSFILTGFAFREVGGYEAFMDKYMKAIPTLVSD--GNITVKEECYTPRADSFHIFRD 268

  Fly   238 ---GGIPW------------------QVYFQRVLSSKTAGRAQ----LLSYVAAAGCILMAIPPV 277
               |.:||                  ||..||.||:|.....:    |..|:......||.:|.:
  Rat   269 PITGDMPWPGLIFGLSILALWYWCTDQVIVQRCLSAKNMSHVKAGCTLCGYLKLLPMFLMVMPGM 333

  Fly   278 L-----IGAIAKATPWNETDYKGPYPLTVDETSMILPMVLQYLTPDFVSFFGLGAVSAAVMSSAD 337
            :     ...||...|.....|.|   ..|..|::..|.::..|.|:.:....|..:.|::|||..
  Rat   334 ISRILYTDKIACVLPSECKKYCG---TPVGCTNIAYPTLVVELMPNGLRGLMLSVMMASLMSSLT 395

  Fly   338 SSVLSAASMFARNVYKLIFRQKASEMEIIWVMRVAIIVVGILATIMALTIPSIYGLWS-MCSDLV 401
            |...||:::|..::|..| |:.|||.|::...|:.|:|   |..|....:|.:....| ...|.:
  Rat   396 SIFNSASTLFTMDIYTKI-RKGASEKELMIAGRLFILV---LIGISIAWVPIVQSAQSGQLFDYI 456

  Fly   402 YVI---LFPQL---LMVVHFKKHCNTYGSLSAYIVALAIRLSGGEAILGLAPLIKYPGYDEETKE 460
            ..|   |.|.:   .::..|.|..|..|:....|:..         ::|::.:|....|.  |..
  Rat   457 QSITSYLGPPIAAVFLLAIFCKRVNEPGAFWGLILGF---------LIGISRMITEFAYG--TGS 510

  Fly   461 QMFP--------------FRTMAMLLSLVTLISVSWWTKMMFESGKLPPSYDYFRC--VVNIPED 509
            .|.|              |..:...:|:||::.:|..||      .:|..:.|..|  :.|..|
  Rat   511 CMEPSNCPKIICGVHYLYFAIILFAISVVTVLVISLLTK------PIPDVHLYRLCWSLRNSTE- 568

  Fly   510 VQRVGDPSESGEQLSVMAGPLARSYGAATMAGKDERNGRINPALESDDDLPVAE----------- 563
             :|:  ..::||:..|...|            ||        .:|.|.:.|..|
  Rat   569 -ERI--DLDAGEEEPVEEDP------------KD--------TIEIDAEAPQKEKGCFRKAYDLF 610

  Fly   564 -------ARRINQETAQAQVKKMLDNATGVKP 588
                   ..::.:|..:|...||.|  |..||
  Rat   611 CGLDQDKGPKMTKEEEEAMKLKMTD--TSEKP 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	122/549 (22%)
Slc5a1	NP_037165.1	SLC5-6-like_sbd	27..665	CDD:444915	150/680 (22%)