Protein Alignment ChT and Slc5a2

DIOPT Version :10

• Sequence 1: NP_650743.1
• Gene: ChT / 42245
• FlyBaseID: FBgn0038641
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_573517.1
• Gene: Slc5a2 / 246787
• MGIID: 2181411
• Length: 670
• Species: Mus musculus
• Alignment Length: 733
• Identity: 154/733 - (21%)
• Similarity: 261/733 - (35%)
• Gaps: 248/733 - (33%)

  Fly     3 NIAGVVSIVLFYLLILVVGIWAGRKKQSGNDSEEEVMLAGRSIGLFVGIFTMTATWVGGGYINGT 67
            |.|.::.|..::||::.||:|:..:...|  :.....|||||:..:....::.|:.:|.|:..|.
Mouse    20 NPADILVIAAYFLLVIGVGLWSMFRTNRG--TVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGL 82

  Fly    68 AEAIYTSGLVWCQAPFGYALSLVFG----GIFFANPMRKQGYITMLDPLQDSFG----------- 117
            |.....|||    |..|:..:.:|.    |..|.......|.|||...|:..||
Mouse    83 AGTGAASGL----AVAGFEWNALFVVLLLGWLFVPVYLTAGVITMPQYLRKRFGGHRIRLYLSVL 143

  Fly   118 ------------ERMGGLLFLPALCGEVFW--AAGILAALGATLSVIIDMDHRTSVILSSCIAIF 168
                        :...|.:|:....|   |  .|.::|.||.|:                    .
Mouse   144 SLFLYIFTKISVDMFSGAVFIQQALG---WNIYASVIALLGITM--------------------I 185

  Fly   169 YTLFGGLYSVAYTDVIQLFCIFIGLWMCIPFAWS---------NEHVGSLSDLEVD---WIGHV- 220
            ||:.|||.::.|||.:|.|.|..|.::...:|:.         ::::|:::.|.|.   .:|::
Mouse   186 YTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAMTSLTVSKDPSVGNIS 250

  Fly   221 ----EPKKHWLYIDYGLLL--VFGGIPW------------------QVYFQRVLSSKTAGRAQLL 261
                :|:..    .|.||.  |.|.:||                  ||..||.|:.|.      |
Mouse   251 STCYQPRPD----SYHLLRDPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKN------L 305

  Fly   262 SYVAAAGCIL---MAIPP----VLIGAIAKATPWNETDYKGPYPLTVDETSMILPMV-------- 311
            ::: .|||||   :.:.|    |:.|.|::..          ||   ||.:.::|.|
Mouse   306 THI-KAGCILCGYLKLMPMFLMVMPGMISRIL----------YP---DEVACVVPEVCKRVCGTE 356

  Fly   312 -----LQY------LTPDFVSFFGLGAVSAAVMSSADSSVLSAASMFARNVYKLIFRQKASEMEI 365
                 :.|      |.|:.:....|..:.||:|||..|...|::::|..::|..: |.:|.:.|:
Mouse   357 VGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRL-RPRAGDKEL 420

  Fly   366 -----IWVMRVAIIVVGILATIMALT-------IPSIYGLWSMCSDLVYVILFPQLLMVVHFKKH 418
                 :||:.:..:.|..|..:.|..       |.|:....:.....|:|:..        |...
Mouse   421 LLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLAL--------FVPR 477

  Fly   419 CNTYGSLSAYIVALAIRLSGGEAILGLAPLIKYPGYDEETKEQMFPFRTMAMLLSLVTLISVSWW 483
            .|..|:....:         |..::|||.||
Mouse   478 VNEKGAFWGLV---------GGLLMGLARLI---------------------------------- 499

  Fly   484 TKMMFESGK-LPPS----------YDYFRCVVNIPEDVQRVGDPSESGEQLSVMAGPLARSY--- 534
            .:..|.||. :.||          |.||..::.|...:..:|        :|:...|:.:.:
Mouse   500 PEFFFGSGSCVRPSACPALFCRVHYLYFAIILFICSGILTLG--------ISLCTAPIPQKHLHR 556

  Fly   535 -GAATMAGKDERNGRINPALESDDDLPVAEARR---INQETAQAQVKKMLDNA----TGVKPSGG 591
             ..:....|:||.......||.....||....:   :..|..|:....:|...    .|:..||
Mouse   557 LVFSLRHSKEEREDLDADELEGPAPAPVQNGGQECAMEMEEVQSPAPGLLRRCLLWFCGMSKSG- 620

  Fly   592 GGGHLQSQSGMAMPTAEQ 609
                    ||...||.|:
Mouse   621 --------SGSPPPTTEE 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	122/577 (21%)
Slc5a2	NP_573517.1	SLC5-6-like_sbd	22..670	CDD:444915	153/731 (21%)