Protein Alignment ChT and SLC5A11

DIOPT Version :10

• Sequence 1: NP_650743.1
• Gene: ChT / 42245
• FlyBaseID: FBgn0038641
• Length: 614
• Species: Drosophila melanogaster
• Sequence 2: NP_001339171.1
• Gene: SLC5A11 / 115584
• HGNCID: 23091
• Length: 675
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 131/580 - (22%)
• Similarity: 236/580 - (40%)
• Gaps: 151/580 - (26%)

  Fly     7 VVSIVLFYLLILVVGIWAGRKKQSGNDSEEEVMLAGRSIGLFVGIFTMTATWVGGGYINGTAEAI 71
            :..:||::|.:|.||:|:..|.:  .|:.:...|||..:..:....::.|:.||.|:..|.|.:.
Human    29 IAVLVLYFLFVLAVGLWSTVKTK--RDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSG 91

  Fly    72 YTSGLVWCQAPFGYALSLVFGGIFFA---NPMRKQGYITMLDPLQDSFGERMGGLLFLPALCGEV 133
            ..:|:    :...|.|:.:|..:..|   .|:...|.:|   .:.:...:|.||:. :|.:...:
Human    92 AATGI----SVSAYELNGLFSVLMLAWIFLPIYIAGQVT---TMPEYLRKRFGGIR-IPIILAVL 148

  Fly   134 FWAAGILAALGATL---SVIID----MDHRTSVILSSCIAIFYTLFGGLYSVAYTDVIQLFCIFI 191
            :....|...:...:   ::.|.    :|...:::....|...||:.|||.:|.|||.:|...:.|
Human   149 YLFIYIFTKISVDMYAGAIFIQQSLHLDLYLAIVGLLAITAVYTVAGGLAAVIYTDALQTLIMLI 213

  Fly   192 GLWMCIPFAWSNEHVGSLSDLEVDWIGHVEPKKHWLYI--------DYGL-----LLVF-----G 238
            |....:.::::  .||.:..|:         :|::|.:        ..||     ..:|     .
Human   214 GALTLMGYSFA--AVGGMEGLK---------EKYFLALASNRSENSSCGLPREDAFHIFRDPLTS 267

  Fly   239 GIPW------------------QVYFQRVLSSK----TAGRAQLLSYVAAAGCILMAIPPVLIGA 281
            .:||                  ||..||.|::|    ..|.|.:.:|:......:|..|    |.
Human   268 DLPWPGVLFGMSIPSLWYWCTDQVIVQRTLAAKNLSHAKGGALMAAYLKVLPLFIMVFP----GM 328

  Fly   282 IAK-------------------ATPWNETDYKGPYPLTVDETSMILPMVLQYLTPDFVSFFGLGA 327
            :::                   :.|...:|.  .||..|.|   :||..|:.|.        :..
Human   329 VSRILFPDQVACADPEICQKICSNPSGCSDI--AYPKLVLE---LLPTGLRGLM--------MAV 380

  Fly   328 VSAAVMSSADSSVLSAASMFARNVYKLIFRQKASEMEIIWVMRVAIIVVGILATIMALTIPSIYG 392
            :.||:|||..|...||:::|..:::..: |.:|||.|::.|.||.::   :|..:..|.||.:..
Human   381 MVAALMSSLTSIFNSASTIFTMDLWNHL-RPRASEKELMIVGRVFVL---LLVLVSILWIPVVQA 441

  Fly   393 LWSMCSDL-VYV-----ILFPQLLMVV---HFKKHCNTYGSLSAYIVALAIRLSGGEAILGLAPL 448
              |....| :|:     .|.|.:.:|.   .|.|..|..|:....|..|         :|||..|
Human   442 --SQGGQLFIYIQSISSYLQPPVAVVFIMGCFWKRTNEKGAFWGLISGL---------LLGLVRL 495

  Fly   449 I-----KYPGYDEETKE----QMFPFRTMAMLLSLVTLI---SVSWWTKMMFESGKLPPS 496
            :     ..|..|:..:.    :...:...:|:||.||||   :|||:|:        |||
Human   496 VLDFIYVQPRCDQPDERPVLVKSIHYLYFSMILSTVTLITVSTVSWFTE--------PPS 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ChT	NP_650743.1	SLC5sbd_CHT	7..481	CDD:271368	124/563 (22%)
SLC5A11	NP_001339171.1	SLC5sbd_SGLT6	28..675	CDD:271381	131/580 (23%)