DRSC/TRiP Functional Genomics Resources

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Protein Alignment: CG15803 and LNX1

Sequence 1:NP_001287388.1 Gene:CG15803 FlyBaseID:FBgn0038606 Length:880 Species:Drosophila melanogaster
Sequence 2:NP_001119800.1 Gene:LNX1 HGNCID:6657 Length:728 Species:Homo sapiens

Alignment Length:569 Identity:120/570 (21%)
Similarity:205/570 (36%) Gaps:166/570 (29%)


  Fly   164 LVGLVRGGPAEGTELSAVEPQPSAAVLQLQQLSELAGDLADFPLPPI------------------ 210
            |..|:..|.....:::.|:|..|.::       .|.|. ::.||..|                  
Human   263 LYHLIPDGEITSIKINRVDPSESLSI-------RLVGG-SETPLVHIIIQHIYRDGVIARDGRLL 319

  Fly   211 PGGGGHSMVTDSNAGQRPCPRLDLDIVPFSILSPPPRPALQML--PLETQWRCVQDQNRHIETVI 273
            ||    .::...|.       :|:..||.:.       |:::|  |.:..|.          ||:
Human   320 PG----DIILKVNG-------MDISNVPHNY-------AVRLLRQPCQVLWL----------TVM 356

  Fly   274 ADSKRKLLANEDGGSASASGSGSPDSYMDSPETETYVVELHKN--VYGLGITVAGYVCEEEDLSG 336
            .:.|.:          |.:...:||:|  .|..:::.|.|:|:  ...|||.:...|    |..|
Human   357 REQKFR----------SRNNGQAPDAY--RPRDDSFHVILNKSSPEEQLGIKLVRKV----DEPG 405

  Fly   337 IFVKSIIEGSAAETSGQIQINDRIVAVDGRSLSGVTNHQAVELLRNTDIVVHLTLERFLRGRKYE 401
            :|:.::::|..|...||::.|||::|::|..|...:...|..|::.::..|||.:.|.:|.|..:
Human   406 VFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPD 470

  Fly   402 HLQVALTEIKGTSAPSGLDRSQ------------------DKDQDQESQLSMPGSPS-------I 441
            ..|.|.....|:.:|...:||.                  .||..:...:::.|..|       |
Human   471 IFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPI 535

  Fly   442 ATLSWLPPKSLDADSIATEGDEAVDAEYVGISGAEDEFIELPSRDTVESNMSHVLDRSDHSGGLT 506
            ..:|..|...:..|.....||..::.:.|       |..|:...:.|.     :|.|:..|..|.
Human   536 YVISVEPGGVISRDGRIKTGDILLNVDGV-------ELTEVSRSEAVA-----LLKRTSSSIVLK 588

  Fly   507 KDQVPRISPIVPLTNGRSLILADDSGNDTDEQCAEPETETAQARKGSKPETERVKDLGDTKTDTD 571
            ..:|....|                    .|.|:.|...                   |:..:..
Human   589 ALEVKEYEP--------------------QEDCSSPAAL-------------------DSNHNMA 614

  Fly   572 PDPDLDPG-----QMPTPT-NEAPVKAASPTAASLRVAWKSLGISLEGTVDVECGIEKRPHHYIR 630
            |..|..|.     ::|... |...:.....||.       |||..:.|..:...|  .:| .:|:
Human   615 PPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAG-------SLGFCIVGGYEEYNG--NKP-FFIK 669

  Fly   631 SILADGPVGRQGILRPGDELLQVNEHKLQGLRHIEVVKILKELPARVKL 679
            ||:...|....|.:|.||.||.||.....|:.|..:.::||||..|:.|
Human   670 SIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITL 718

Known Domains:


GeneSequenceDomainRegion External IDIdentity
CG15803NP_001287388.1 PDZ_signaling 17..89 CDD:238492
PDZ 307..393 CDD:214570 25/88 (28%)
PDZ_signaling 605..680 CDD:238492 26/76 (34%)
PDZ 773..858 CDD:214570
LNX1NP_001119800.1 mRING-HC-C3HC3D_LNX1 38..79 CDD:319693
modified RING-HC finger (C3HC3D-type) 41..78 CDD:319693
NPXY motif 181..184
Interaction with MAGEB18. {ECO:0000269|PubMed:20864041} 186..244
PDZ_signaling 272..355 CDD:238492 19/119 (16%)
PDZ_signaling 380..460 CDD:238492 25/84 (30%)
PDZ_signaling 505..588 CDD:238492 18/95 (19%)
PDZ_signaling 637..721 CDD:238492 28/93 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
eggNOG 1 0.900 E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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