DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8064 and CG16896

DIOPT Version :9

Sequence 1:	NP_650705.1	Gene:	CG8064 / 42196	FlyBaseID:	FBgn0038597	Length:	922	Species:	Drosophila melanogaster
Sequence 2:	NP_611973.2	Gene:	CG16896 / 37977	FlyBaseID:	FBgn0035073	Length:	988	Species:	Drosophila melanogaster

Alignment Length:	861	Identity:	172/861 - (19%)
Similarity:	289/861 - (33%)	Gaps:	267/861 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   260 TIQRAGKGRTVNLVTDPSERVISCHG--TNDLI-----ENFYICTPDEVKK---RLAKRLKKEKK 314
            ||:.||:...:.:..       .|..  :|.|:     .|.::.  |.|:|   ||..|:.|.|.
  Fly   102 TIKEAGQALRIQIAA-------CCFNELSNKLVVIDKRGNVFVF--DFVRKRYWRLGFRMPKAKL 157

  Fly   315 VAED--EGSDEAKLSTEQSLSDEIKRLESIRAKQKIKSIDVVLGQN--QELRVLVSLAN--NSLC 373
            :...  .|||       ..:.::...:.:|.....|..:|..:|..  :||....||.|  :|:.
  Fly   158 IRPSPLHGSD-------YIVGNKTGHIFTIDVDNSILGVDGEVGSAALEELSWSNSLQNARSSIA 215

  Fly   374 LY-----SLEASIKTRKAT-----DPSAKLLRSLTRLGHQSEVRSVCFSNDSLAIGSG------- 421
            |.     :|..::.|.:.:     |.|...|:....|.| |:...:.||||||.:.|.
  Fly   216 LMRFGSDALLVNLHTLEVSHQLDFDQSRYTLKFAAFLPH-SDQFFIGFSNDSLHVWSSHSLSTLR 279

  Fly   422 AGESFKFWDRDAMQCLRTVPT----------------------------DY----ILCSKFVPGD 454
            .|:..|..:|.    ||.:|.                            |:    :|...|.|..
  Fly   280 MGQPIKARNRK----LRLLPAAESIPEIVLRSPDDSDLEEDLTFDCQHYDFADGMLLSYCFTPDG 340

  Fly   455 RYVLLGMKSGKLLIVDVAAADIVEEIPAHEGELWSIAILPDQKGCVTGSGDTT------------ 507
            ..:.|....|.||::.||:.|:.:.....:..|..:|.|...|..:. .|.||
  Fly   341 NKMCLSTLDGYLLLLSVASFDLEKMYRLTDFTLHQMAFLSQPKERIV-FGITTRNQAVMLDLANT 404

  Fly   508 -------------------------------VKIW-TFELIDAGEGAAQTKVLSLLHKNTLKLEE 540
                                           |.:| |..:.:|.:  ||.:.||.: |:|.|...
  Fly   405 DHKLIVQRSNARSLSLSRDGKLLSVTSRCGEVNVWSTCRIFNALQ--AQIRCLSQV-KSTFKQPN 466

  Fly   541 TVLCLAVSPDMKYLAVGLLDATVKVFFLDTFKFYLSLYGHKLPVICLD-----------ISYDSN 594
            .:...:|...:......||:.......|..:..|...|.:.:....||           |...:.
  Fly   467 PLPPCSVGGGVSKELRDLLNPQRLKTMLKEYGCYPEKYRYLIWTSLLDLPCNGPQFQELIKLGAP 531

  Fly   595 LIVTGSAD----RN-------VKVWGLNFGDCHRSIFAHDDSVMSVQFIPRTHMFFTCGKDGKVK 648
            |:|...|.    ||       :|:|......|  .:.||.|      |:|  |:.|..     ||
  Fly   532 LLVRNRAKKLKIRNDHQRRVVIKIWSCLAQWC--KVLAHAD------FMP--HLIFPF-----VK 581

  Fly   649 QWDGDN---FEKILTLP-GHIGEAYCLSVSPNGRYLVTCGS-----DRTLRMFERTDETIVLKD- 703
            :...::   ||.|.||. .|....:.....|...||..|.:     |..|..|.::.| ::.||
  Fly   582 RMPKNSLVCFELIATLVLNHFQLCFEFHPLPPSNYLAMCENILQHCDEQLCKFYKSQE-MLPKDF 645

  Fly   704 ----VQEEEREQMENEQLATGEDNTV---PLLPG--------------LKMPSRKTV---GSEQS 744
                :.....|.:|.||..:..||..   |..|.              |::|.:::|   ..:|:
  Fly   646 AWPLLSTAFSEVLEEEQWLSLWDNIFSEPPWFPVFLVVAYNLINREIILRLPDKRSVLFFFHDQN 710

  Fly   745 AESILECLEISKQFELEAEEKPELHP--LMQALQ----------VKNPEDFL-------VSTL-- 788
            ...|.:.|  ||..:|.::....|||  .|....          :|.|.:::       ||.:
  Fly   711 PVDISKLL--SKARKLMSKCALALHPQRFMTHFSPIPKGVYPKFLKYPSEWIDEQEYQAVSLIKH 773

  Fly   789 -----MRIRASDLEEALLLLPFSTVCEVLERLPTLLTQRPDQLELLCRVTIFLFKVHMKPISAAK 848
                 .|||..:|||.          :::|||.|.|.|......|.....::...:|.:......
  Fly   774 NQEIDARIRHLELEEV----------KIMERLETGLKQEEHARRLKEMERVYQDTIHREEERITC 828

  Fly   849 NMKPLLVKLLSMLKR---------DVGQLRDVLGWNLHGLALLQTEVEQRDGVQLFREATQTRKK 904
            ..|.||...:.:.:|         :..|.|.:|              |....:.|...:.:..::
  Fly   829 QRKMLLTYQMEVRRRKSEVITKLQESEQRRKIL--------------EMEKDMDLLMHSIERERR 879

  Fly   905 RDKKRREASKRRLQIQ 920
            |..:..:.::..::.|
  Fly   880 RHNQEMQLAEDEIRNQ 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8064	NP_650705.1	WD40	<45..288	CDD:225201	5/29 (17%)
		WD40	60..511	CDD:295369	70/358 (20%)
		WD40 repeat	69..108	CDD:293791
		WD40 repeat	113..149	CDD:293791
		WD40 repeat	156..194	CDD:293791
		WD40 repeat	200..236	CDD:293791
		WD40	331..702	CDD:225201	101/498 (20%)
		WD40 repeat	349..398	CDD:293791	14/62 (23%)
		WD40	401..693	CDD:238121	82/405 (20%)
		WD40 repeat	408..441	CDD:293791	12/39 (31%)
		WD40 repeat	446..482	CDD:293791	10/35 (29%)
		WD40 repeat	487..535	CDD:293791	16/91 (18%)
		WD40 repeat	543..578	CDD:293791	5/34 (15%)
		WD40 repeat	584..621	CDD:293791	11/58 (19%)
		WD40 repeat	626..662	CDD:293791	10/38 (26%)
		WD40 repeat	669..692	CDD:293791	6/27 (22%)
		Utp12	780..882	CDD:281932	24/124 (19%)
CG16896	NP_611973.2	WD40	228..>467	CDD:225201	49/247 (20%)
		BAR	766..>952	CDD:299863	27/154 (18%)
		SPFH_like	<817..909	CDD:302763	12/93 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470261
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19853
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030