Protein Alignment CG7156 and SNX25

DIOPT Version :10

• Sequence 1: NP_650697.1
• Gene: CG7156 / 42187
• FlyBaseID: FBgn0038588
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_001364961.1
• Gene: SNX25 / 83891
• HGNCID: 21883
• Length: 1037
• Species: Homo sapiens
• Alignment Length: 773
• Identity: 151/773 - (19%)
• Similarity: 258/773 - (33%)
• Gaps: 268/773 - (34%)

  Fly     9 IHSFTVTDTQEHKGGYTIYKITSIVFPRSVPQALTCLVVWKRFHDVKRLHRELSRRHKSLQLPGK 73
            |.||  ...:.|||..|......::..|::.:.:..|.|.|         ::..:|.:.|..|
Human   410 ISSF--PQLKRHKGKETAAMKADLLRARNMKRYINQLTVAK---------KQCEKRIRILGGP-- 461

  Fly    74 LPVPTDSTYFKRFDAAVIQ---RRKEYILQLLD-----FAAQHPALY-------KCSTFTQFFQE 123
                   .|.::.|.|:.:   .:.:.|||..|     |..:|..:|       ...:|.:..:.
Human   462 -------AYDQQEDGALDEGEGPQSQKILQFEDILANTFYREHFGMYMERMDKRALISFWESVEH 519

  Fly   124 TPSPNGSPL---------------KKLYVERSLRLQTEDNGCGSGGSET---------GTC---- 160
            ..:.|.:.:               |::.||:||..:.:....|:.|.|.         .|.
Human   520 LKNANKNEIPQLVGEIYQNFFVESKEISVEKSLYKEIQQCLVGNKGIEVFYKIQEDVYETLKDRY 584

  Fly   161 --AGAIADICDKLDLPYDPHDAGGITPLDPRCDKEQTNNESQAKETEIELETKQEPKTDVALTKR 223
              :..::|:.:||.:                  ||:..:.||....:.|:..:.|...:..
Human   585 YPSFIVSDLYEKLLI------------------KEEEKHASQMISNKDEMGPRDEAGEEAV---- 627

  Fly   224 DYLRLLTPMASIESDDSDYIYEAALEFSHAVQ--AEVN--LEYAEAHERYKHGVDLLLNGAKQDS 284
                         .|.::.|.|.|   |.||.  .|:|  |||.      :..::.:.|..|.|
Human   628 -------------DDGTNQINEQA---SFAVNKLRELNEKLEYK------RQALNSIQNAPKPD- 669

  Fly   285 SEERRFIAKAKIAKYLARAEEIHANFLANDCPTKKLQFQLSLDTTD--------------GGSVS 335
               ::.::|.|....|...|              :...||.:..||              .|.|:
Human   670 ---KKIVSKLKDEIILIEKE--------------RTDLQLHMARTDWWCENLGMWKASITSGEVT 717

  Fly   336 HLECPWNQLARYKVLQILQD-------------RVMQVQCV-TKSQQPAAIMKGVEKPASHSLT- 385
              |....||..|.|:..||:             |:.:.|.: .|..:....:|.|:.|:...|.
Human   718 --EENGEQLPCYFVMVSLQEVGGVETKNWTVPRRLSEFQNLHRKLSECVPSLKKVQLPSLSKLPF 780

  Fly   386 QSI---FLPQQVPYMVQLLAYFQSEQKIFLLLRQAEGGMLY-------DYLQSYTPTSSKS---- 436
            :||   |:.:....:.:.|....|:::    |.|:|.  ||       |||:.......|:
Human   781 KSIDQKFMEKSKNQLNKFLQNLLSDER----LCQSEA--LYAFLSPSPDYLKVIDVQGKKNSFSL 839

  Fly   437 VNYGELFPSD-QEPEEKEAEEPPLTSDSDVSDLVRSSQQLLKSVTNTLSNLQAGVVTPKRNKKVD 500
            .::.|..|.| ...:|:|.||     |||:||.                           ...||
Human   840 SSFLERLPRDFFSHQEEETEE-----DSDLSDY---------------------------GDDVD 872

  Fly   501 QNRIRSKPIPEQC---------LR---QWACELAIA-IHSLHGKGV--ILRDLHMGNILLGAKGQ 550
            .   |...:.|.|         ||   :|.....|| :....|:.:  .:||
Human   873 G---RKDALAEPCFMLIGEIFELRGMFKWVRRTLIALVQVTFGRTINKQIRD------------- 921

  Fly   551 LLLTYFYQNEGLTSDDNYVHKALNLEAVANHFVAPERPLTFRSDWWSYGV---VLYQLLLGVP-- 610
             .:::.:..:.|....|....|.    ..|..:||  |.|.||...|...   ...:||..:|
Human   922 -TVSWIFSEQMLVYYINIFRDAF----WPNGKLAP--PTTIRSKEQSQETKQRAQQKLLENIPDM 979

  Fly   611 -------YKVTHPGQLDLYGCVQYPSESLEISDHAKDLLEQLLQLSPELRLDYDQLQA 661
                   ....| |.:.::..:|....:..:.....:||  |::|.||||:..|||:|
Human   980 LQSLVGQQNARH-GIIKIFNALQETRANKHLLYALMELL--LIELCPELRVHLDQLKA 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7156	NP_650697.1	PX_SNX15_like	8..124	CDD:132791	25/129 (19%)
		MIT_SNX15	241..315	CDD:239140	18/77 (23%)
		Protein Kinases, catalytic domain	343..665	CDD:473864	81/376 (22%)
SNX25	NP_001364961.1	PXA	166..321	CDD:460484
		235kDa-fam	<331..>691	CDD:130673	63/362 (17%)
		RGS_SNX25	488..596	CDD:188675	15/107 (14%)
		PX_SNX25	699..821	CDD:132788	26/129 (20%)
		Nexin_C	898..1004	CDD:462541	23/126 (18%)