Protein Alignment CG7156 and RPS6KA2

DIOPT Version :10

• Sequence 1: NP_650697.1
• Gene: CG7156 / 42187
• FlyBaseID: FBgn0038588
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: XP_006715612.1
• Gene: RPS6KA2 / 6196
• HGNCID: 10431
• Length: 761
• Species: Homo sapiens
• Alignment Length: 341
• Identity: 78/341 - (22%)
• Similarity: 136/341 - (39%)
• Gaps: 121/341 - (35%)

  Fly   350 LQILQDRVMQVQCVTKSQQPAAIMKGVEKPASHSLTQSIFLPQQVPYMVQLLAYFQSEQKIFLLL 414
            :::|:...::|:...:|:....|:..|    :|            |::|:|...||:|.|::|:|
Human   118 MKVLKKATLKVRDRVRSKMERDILAEV----NH------------PFIVKLHYAFQTEGKLYLIL 166

  Fly   415 RQAEGGMLYDYLQSYTPTSSKSVNYGELFPSDQEPEEKEAEEPPLTSDSDVSDLVRSSQQLLKSV 479
                     |:|:.           |:||                         .|.|::::
Human   167 ---------DFLRG-----------GDLF-------------------------TRLSKEVM--- 183

  Fly   480 TNTLSNLQAGVVTPKRNKKVDQNRIRSKPIPEQCLRQWACELAIAIHSLHGKGVILRDLHMGNIL 544
                                         ..|:.::.:..|||:|:..||..|:|.|||...|||
Human   184 -----------------------------FTEEDVKFYLAELALALDHLHSLGIIYRDLKPENIL 219

  Fly   545 LGAKGQLLLTYF-YQNEGLTSDDNYVHKALNLEAVANHFVAPE----RPLTFRSDWWSYGVVLYQ 604
            |..:|.:.:|.| ...|.:..|.........:|     ::|||    |..|..:||||:||::::
Human   220 LDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIE-----YMAPEVVNRRGHTQSADWWSFGVLMFE 279

  Fly   605 LLLG-VPY-----KVTHPGQLDL-YGCVQYPSESLEISDHAKDLLEQLLQLSPELRL-----DYD 657
            :|.| :|:     |.|....|.. .|..|:      :|..|:.||..|.:.:|..||     ..:
Human   280 MLTGSLPFQGKDRKETMALILKAKLGMPQF------LSGEAQSLLRALFKRNPCNRLGAGIDGVE 338

  Fly   658 QLQAHPFFKGIDWQAV 673
            :::.||||..|||..:
Human   339 EIKRHPFFVTIDWNTL 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7156	NP_650697.1	PX_SNX15_like	8..124	CDD:132791
		MIT_SNX15	241..315	CDD:239140
		Protein Kinases, catalytic domain	343..665	CDD:473864	73/331 (22%)
RPS6KA2	XP_006715612.1	STKc_RSK_N	91..407	CDD:270734	78/341 (23%)
		STKc_RSK3_C	439..731	CDD:271080